Molecules,
Journal Year:
2024,
Volume and Issue:
29(5), P. 968 - 968
Published: Feb. 22, 2024
Since
the
discovery
of
classical
chiral
oxazoline
ferrocene
ligands
in
1995,
they
have
become
pivotal
transition
metal-catalyzed
asymmetric
transformations.
Over
past
decade,
a
notable
evolution
has
been
observed
with
emergence
siloxane-substituted
ferrocenes,
demonstrating
significant
potential
as
and
catalysts.
These
compounds
consistently
delivered
exceptional
results
diverse
mechanistically
distinct
transformations,
surpassing
capabilities
ligands.
This
review
meticulously
delineates
research
progress
on
compounds.
It
encompasses
synthesis
crucial
precursors
desired
products,
highlights
their
achievements
catalysis
reactions,
delves
into
exploration
derivatization
these
compounds,
emphasizing
introduction
ionophilic
groups
impact
recovery
metal
In
addition
to
presenting
current
state
knowledge,
this
propels
future
directions
by
identifying
topics
for
further
investigation
concerning
siloxane-tagged
derivatives.
derivatives
are
poised
be
promising
candidates
next
generation
highly
efficient
Organic Letters,
Journal Year:
2025,
Volume and Issue:
unknown
Published: March 25, 2025
Among
numerous
fluorine-containing
molecules,
chiral
gem-difluoroethylenes
(C═CF2)
exhibited
unique
properties
in
agrochemicals,
pharmaceuticals,
and
materials
science.
However,
the
general
synthetic
methods
were
limited
to
functionalization/defluorination
of
trifluoromethylalkenes.
Here,
we
disclose
a
new
type
difluoroethylenyl
reagent,
α,α-difluoro
allylsulfones,
which
allows
highly
enantioselective
Cu-catalyzed
desulfonylative
SN2′
substitution
with
benzylideneamino
esters.
This
protocol
presents
novel
strategy
for
construction
diversified
α-quaternary
amino
acid
derivatives
containing
gem-difluoroethylene
moiety
excellent
results
(up
86%
yield,
generally
90–98%
ee).
The
ease
synthesis
applications
this
protocol,
transformations
products
revealed
potential
utility
chemistry.
Organic Letters,
Journal Year:
2024,
Volume and Issue:
26(12), P. 2349 - 2353
Published: March 15, 2024
Enantioselective
construction
of
all-carbon
quaternary
centers
has
been
achieved
via
the
palladium-catalyzed
highly
enantioselective
allenylation
oxindoles
with
2,3-allenylic
carbonates
to
afford
a
variety
optically
active
allene
products,
which
contain
oxindole
units
different
functional
groups,
in
high
ee.
The
corresponding
synthetic
applications
have
also
demonstrated.
Journal of the American Chemical Society,
Journal Year:
2024,
Volume and Issue:
unknown
Published: Sept. 12, 2024
Enantioenriched
unnatural
amino
acids
represent
a
prevalent
motif
in
organic
chemistry,
with
profound
applications
biochemistry,
medicinal
and
materials
science.
Herein,
we
report
cobalt-catalyzed
aza-Barbier
reaction
of
dehydroglycines
unactivated
alkyl
halides
to
afford
α-amino
esters
high
enantioselectivity.
This
catalytic
reductive
alkylative
addition
protocol
circumvents
the
use
moisture-,
air-sensitive
organometallic
reagents,
stoichiometric
chiral
auxiliaries,
enabling
conversion
variety
primary,
secondary,
even
tertiary
α-alkyl-amino
under
mild
conditions,
thus
leading
broad
functional
group
tolerance.
The
expedient
access
biologically
active
motifs
demonstrates
practicality
this
by
reducing
number
synthetic
steps
enhancing
efficiency.
Organic Letters,
Journal Year:
2023,
Volume and Issue:
25(31), P. 5790 - 5794
Published: July 31, 2023
A
chiral
aldehyde/palladium
catalysis-enabled
asymmetric
α-allylation
of
NH2-unprotected
amino
acid
esters
with
1,3-disubstituted
allyl
acetates
is
described
in
this
work.
With
the
utilization
different
phosphine
ligands,
both
anti-
and
syn-selective
allylation
reactions
are
achieved
enantioselectively.
series
α,α-disubstituted
bearing
two
adjacent
centers
produced
moderate-to-excellent
yields,
diastereoselectivities,
enantioselectivities.
Molecules,
Journal Year:
2024,
Volume and Issue:
29(5), P. 968 - 968
Published: Feb. 22, 2024
Since
the
discovery
of
classical
chiral
oxazoline
ferrocene
ligands
in
1995,
they
have
become
pivotal
transition
metal-catalyzed
asymmetric
transformations.
Over
past
decade,
a
notable
evolution
has
been
observed
with
emergence
siloxane-substituted
ferrocenes,
demonstrating
significant
potential
as
and
catalysts.
These
compounds
consistently
delivered
exceptional
results
diverse
mechanistically
distinct
transformations,
surpassing
capabilities
ligands.
This
review
meticulously
delineates
research
progress
on
compounds.
It
encompasses
synthesis
crucial
precursors
desired
products,
highlights
their
achievements
catalysis
reactions,
delves
into
exploration
derivatization
these
compounds,
emphasizing
introduction
ionophilic
groups
impact
recovery
metal
In
addition
to
presenting
current
state
knowledge,
this
propels
future
directions
by
identifying
topics
for
further
investigation
concerning
siloxane-tagged
derivatives.
derivatives
are
poised
be
promising
candidates
next
generation
highly
efficient
