Angewandte Chemie,
Journal Year:
2024,
Volume and Issue:
136(47)
Published: Aug. 12, 2024
Abstract
C(
sp
3
)
centers
adjacent
to
(hetero)
aryl
groups
are
widely
present
in
physiologically
active
molecules.
Metal‐hydride‐catalyzed
hydroalkylation
of
alkenes
represents
an
efficient
means
forging
)−C(
bonds,
boasting
advantages
as
a
wide
source
substrates,
mild
reaction
conditions,
and
facile
selectivity
manipulation.
Nevertheless,
the
vinylarenes
encounters
constraints
terms
substrate
scope,
necessitating
employment
activated
alkyl
halides
or
containing
chelating
groups,
remains
challenge.
In
this
context,
we
report
general
nickel‐hydride‐catalyzed
protocol
for
vinylarenes.
Remarkably,
system
enables
α‐selective
both
heteroaryl
under
extra
ligand‐free
condition,
demonstrating
excellent
coupling
efficiency
selectivity.
Furthermore,
through
incorporation
chiral
bisoxazoline
ligands,
have
achieved
regio‐
enantioselective
vinylpyrroles,
thereby
facilitating
synthesis
α‐branched
alkylated
pyrrole
derivatives.
Angewandte Chemie,
Journal Year:
2023,
Volume and Issue:
135(30)
Published: May 31, 2023
Abstract
Cyclopropene
hydrofunctionalization
has
been
a
promising
strategy
for
accessing
multi‐substituted
cyclopropanes;
however,
cyclopropene
hydroalkylation
remains
underdeveloped.
Herein,
we
report
low‐valent
CoH‐catalyzed
facial‐selective
to
access
cyclopropanes.
This
reaction
exhibits
broad
substrate
scope
of
alkyl
halides
and
cyclopropenes
tolerates
many
functional
groups.
Moderate‐to‐good
facial‐selectivity
is
obtained
without
any
directing
Mechanism
studies
provide
evidence
that
radicals
are
generated
from
irreversible
CoH
insertion
responsible
the
facial‐selectivity.
Our
preliminary
exploration
demonstrates
asymmetric
can
be
realized
conspicuous
auxiliary
Synlett,
Journal Year:
2024,
Volume and Issue:
unknown
Published: June 19, 2024
Abstract
Carbohydrates
and
their
conjugates
play
important
roles
in
life
activities
drug
development.
Our
group
was
committed
to
the
general
effective
glycosylation
methods
application
chemical
biology
using
unsaturated
glycosyl
donors.
In
past
five
years,
we
have
reported
several
synthetic
strategies
with
high
stereoselectivity
milder
conditions
compared
previous
works.
particular,
chemo-/regio-
stereoselective
O-glycosylation,
C-glycosylation
S-glycosylation
could
be
achieved
via
palladium
catalysis
under
open-air
at
room
temperature.
this
Account,
will
introduce
our
research
progress
constructing
four
types
of
glycosides.
1
Introduction
2
Stereoselective
Synthesis
O-Glycosides
3
C-Glycosides
4
N-Glycosides
5
S-Glycosides
6
Conclusion
Angewandte Chemie,
Journal Year:
2024,
Volume and Issue:
136(47)
Published: Aug. 12, 2024
Abstract
C(
sp
3
)
centers
adjacent
to
(hetero)
aryl
groups
are
widely
present
in
physiologically
active
molecules.
Metal‐hydride‐catalyzed
hydroalkylation
of
alkenes
represents
an
efficient
means
forging
)−C(
bonds,
boasting
advantages
as
a
wide
source
substrates,
mild
reaction
conditions,
and
facile
selectivity
manipulation.
Nevertheless,
the
vinylarenes
encounters
constraints
terms
substrate
scope,
necessitating
employment
activated
alkyl
halides
or
containing
chelating
groups,
remains
challenge.
In
this
context,
we
report
general
nickel‐hydride‐catalyzed
protocol
for
vinylarenes.
Remarkably,
system
enables
α‐selective
both
heteroaryl
under
extra
ligand‐free
condition,
demonstrating
excellent
coupling
efficiency
selectivity.
Furthermore,
through
incorporation
chiral
bisoxazoline
ligands,
have
achieved
regio‐
enantioselective
vinylpyrroles,
thereby
facilitating
synthesis
α‐branched
alkylated
pyrrole
derivatives.
