ChemSusChem,
Journal Year:
2024,
Volume and Issue:
unknown
Published: Oct. 15, 2024
We
report
the
first
metal-
and
catalyst-free
protocol
for
facile
cross-coupling
of
aryl
halides
towards
C-B,
C-P
C-S
bonds
under
solid-state
ball
milling
conditions
via
UV
light
irradiation.
The
reactions
can
be
performed
in
absence
bulk
solvents
at
room
temperature
a
mixer
mill,
yielding
up
to
99
%
being
tolerant
various
functionalized
(X=I
or
Br).
Furthermore,
we
developed
novel
photoreactor
design
increasing
intensity.
With
this
could
demonstrate
that
our
surpasses
classical
solvent
based
as
well
purely
mechanochemical
approaches
terms
green
metrics
energy
efficiency.
RSC Mechanochemistry,
Journal Year:
2024,
Volume and Issue:
1(4), P. 386 - 392
Published: Jan. 1, 2024
This
work
assesses
the
performance
of
16
polymers
in
mechanochemical
reactions,
examining
six
key
parameters:
cost-effectiveness,
environmental
impact,
mechanical-,
thermal-
and
chemical
resistance,
transparency
to
laser-,
X-ray
radiation.
Chemistry - A European Journal,
Journal Year:
2025,
Volume and Issue:
unknown
Published: Jan. 3, 2025
Abstract
We
introduce
mechanochemical
deracemization
(MCDR)
as
a
novel
strategy
for
obtaining
enantiopure
compounds.
This
study
demonstrates
the
successful
transposition
of
six
archetypical
reactions
from
solvent‐based
to
solvent‐minimized
ball
milling
environment.
The
scope
includes
ketone,
isoindolinones,
imines,
an
ester,
and
inorganic
compound,
all
which
deracemized
successfully.
Key
parameters
such
material,
number
size,
use
bulk
material
liquid‐assisted
grinding
(LAG)
were
systematically
investigated,
revealing
their
crucial
role.
Quantitative
enantiomeric
excesses
(ee)
achieved,
while
reaction
times
reduced
by
up
97
%
solvent
consumption
much
100
%.
work
establishes
MCDR
versatile,
sustainable
pathway
By
highlighting
generalizability
this
approach
its
huge
potential
minimizing
waste,
provides
foundation
future
advancements
in
deracemization.
Beilstein Journal of Organic Chemistry,
Journal Year:
2025,
Volume and Issue:
21, P. 458 - 472
Published: March 3, 2025
Photomechanochemistry,
i.e.,
the
merger
of
light
energy
and
mechanical
forces,
is
emerging
as
a
new
trend
in
organic
synthesis,
enabling
unique
reactivities
fleeting
excited
states
under
solvent-minimized
conditions.
Despite
its
transformative
potential,
field
faces
significant
technological
challenges
that
must
be
addressed
to
unlock
full
capabilities.
In
this
Perspective,
we
analyze
selected
examples
showcase
available
technologies
combine
including
manual
grinding,
vortex
shaker
mixing,
rod
milling,
ball
milling.
By
examining
advantages
limitations
each
approach,
aim
provide
an
overview
current
state
synthetic
photomechanochemistry
identify
opportunities
for
future
advancements
rapidly
evolving
area
research.
Nature Communications,
Journal Year:
2025,
Volume and Issue:
16(1)
Published: April 28, 2025
Photocatalysis
has
greatly
advanced
in
organic
synthesis
but
still
confronts
challenges,
including
light
attenuation
reaction
media
and
excessive
solvent
utilization.
These
issues
lead
to
inefficiencies,
particularly
heterogeneous
cloudy
mixtures
scaling-up
applications.
Integrating
photocatalysis
with
mechanochemistry
offers
a
nascent
promising
solution
these
challenges.
Herein,
we
present
scalable
photo-mechanochemical
platform
that
combines
visible-light
Resonant
Acoustic
Mixing
(RAM),
enabling
efficient
cross-coupling
reactions
under
solvent-minimised
conditions.
This
approach
demonstrates
broad
substrate
tolerance,
accommodating
variety
of
aryl
(hetero)
halides
N-,
O-,
P-,
S-nucleophiles.
The
protocol
supports
scaling
up
300
mmol,
representing
1500-fold
increase,
while
maintaining
exceptionally
low
catalyst
loading
achieving
9800
turnover
numbers
(TON).
generality
this
is
further
validated
by
its
applicability
other
synthetic
transformations.
Angewandte Chemie,
Journal Year:
2024,
Volume and Issue:
136(14)
Published: Jan. 5, 2024
Abstract
Mechanochemical
reactions
offer
methodological
and
environmental
advantages
for
chemical
synthesis,
constantly
attracting
attention
within
the
scientific
community.
Besides
unmistakable
sustainability
advantages,
conditions
under
which
mechanochemical
occur,
namely
solventless
conditions,
sometimes
facilitate
isolation
of
otherwise
labile
or
inaccessible
products.
Despite
these
limited
knowledge
exists
regarding
mechanisms
types
intermediates
involved.
Nevertheless,
in
an
expanding
number
cases,
ex
situ
monitoring
techniques
have
allowed
observation,
characterization,
reaction
transformations.
In
this
Minireview,
we
present
a
series
examples
reactive
been
detected
spanning
organic,
organometallic,
inorganic,
materials
chemistry.
Many
were
stabilized
by
non‐covalent
interactions,
played
pivotal
role
guiding
We
believe
that
uncovering
understanding
such
instances,
growing
mechanochemistry
community
could
find
novel
opportunities
catalysis
discover
new
while
achieving
simplification
design.
ChemPlusChem,
Journal Year:
2024,
Volume and Issue:
89(6)
Published: Feb. 9, 2024
Abstract
The
photochemical
cyclodehydrochlorination
(CDHC)
reaction
has
recently
been
used
to
prepare
a
wide
variety
of
polycyclic
aromatic
hydrocarbons
and
graphene
nanoribbons
(GNRs).
However,
the
parameters
affecting
efficiency
this
have
scarcely
studied.
In
work,
we
investigated
how
conditions
influence
outcome
reaction.
effect
functional
groups
on
different
phenyl
rings
o
‐terphenyl
scaffold
was
also
kinetics
follow
same
trend
as
Hammett's
constant
when
electron‐donating
electron‐withdrawing
are
present
ring
bearing
chlorine.
CDHC
can
be
successfully
performed
using
less
energetic
365
nm
light
in
presence
triplet
sensitizer.
Computational
results
provide
insight
mechanism,
notably
by
identifying
its
three
intermediate
structures
well
limiting
step.
JACS Au,
Journal Year:
2023,
Volume and Issue:
3(11), P. 3045 - 3054
Published: Nov. 14, 2023
The
rise
of
interest
in
using
polycyclic
aromatic
hydrocarbons
(PAHs)
and
molecular
graphenoids
optoelectronics
has
recently
stimulated
the
growth
modern
synthetic
methodologies
giving
access
to
intramolecular
aryl-aryl
couplings.
Here,
we
show
that
a
radical-based
annulation
protocol
allows
expansion
planarization
approaches
prepare
functionalized
graphenoids.
enabler
this
reaction
is
peri-xanthenoxanthene,
photocatalyst
which
undergoes
photoinduced
single
electron
transfer
with
an
ortho-oligoarylenyl
precursor
bearing
electron-withdrawing
nucleofuge
groups.
Dissociative
enables
formation
persistent
aryl
radical
intermediates,
latter
undergoing
C-C
bond
formation,
allowing
occur.
conditions
are
mild
compatible
various
-donating
substituents
on
rings
as
well
heterocycles
PAHs.
method
could
be
applied
induce
double
reactions,
synthesis
π-extended
scaffolds
different
edge
peripheries.
Chemistry - A European Journal,
Journal Year:
2024,
Volume and Issue:
unknown
Published: Oct. 10, 2024
Abstract
Transformations
of
solid
samples
under
solvent‐free
or
minimal
solvent
conditions
set
the
future
trend
and
define
a
modern
strategy
for
production
new
materials.
Of
various
technologies
tested
in
recent
years,
mechanochemical
approach
seems
to
be
most
promising
economic
ecological
reasons.
The
aim
this
review
article
is
present
current
state
art
research
on
binary
systems,
which
have
found
numerous
applications
pharmaceutical
materials
science
industries.
This
divided
into
three
sections.
In
first
part,
we
describe
equipment
improvements,
include
innovative
application
thermo‐mechanochemistry,
sono‐mechanochemistry,
photo‐mechanochemistry,
electro‐mechanochemistry,
as
well
resonant
acoustic
mixing
(RAM),
transformation
high‐speed
sample
spinning
(“SpeedMixing”).
A
brief
description
techniques
dedicated
ex‐situ
in‐situ
studies
progress
mechanism
matter
(PXRD,
FTIR,
Raman
NMR
spectroscopy)
presented.
second
section,
discuss
problem
cocrystal
polymorphism
highlighting
issue
related
with
correlation
between
parameters
(
time,
temperature,
energy,
molar
ratio,
used
liquid
assistant,
surface
crystal
size,
shape)
preference
formation
requested
polymorph.
last
part
devoted
processes
coformer
exchange
systems
forced
by
mechanical
and/or
thermal
stimuli.
influence
thermodynamic
factor
selection
best‐suited
partner
two‐component
stable
structure
RSC Mechanochemistry,
Journal Year:
2024,
Volume and Issue:
unknown
Published: Nov. 8, 2024
Ball-milling
allowed
the
efficient
preparation
of
ruthenium
complexes
with
photoredox
properties.
With
a
transparent
and
chemically
resistant
milling
jar
in
epoxy
resin,
photoreductive
dehalogenation
was
realized
efficiently
solventless
manner.
