Synthesis,
Journal Year:
2023,
Volume and Issue:
55(16), P. 2439 - 2459
Published: May 3, 2023
Abstract
Although
known
for
millennia,
it
is
only
recently
that
mechanochemistry
has
received
serious
attention
by
chemists.
Indeed,
during
the
past
15
years
an
extraordinary
number
of
reports
concerning
solid-state
chemical
transformations
through
grinding
and
milling
techniques
have
been
recorded.
This
short
review
discusses
circumstances
led
this
renaissance,
highlighting
present
intense
interest
in
so-called
green
chemistry,
enabling
capacity
to
handle
insoluble
substrates,
identification
profound
influence
additives
can
on
mechanochemically
activated
reactions.
The
core
account
focuses
salient
developments
synthetic
organic
especially
amino
acid
peptide
mechanosynthesis,
successful
employment
mechanochemical
activation
combination
with
asymmetric
organocatalysis,
promising
enzymatic
whole
cell
biocatalysis,
remarkable
achievement
multicomponent
selective
reactions
via
complex,
multistep
reaction
pathways,
mechanosynthesis
representative
heterocycles.
final
section
comments
some
pending
tasks
area,
such
as
scaling-up
processes
be
practical
use
industry,
requirement
easier
more
efficient
control
parameters
monitoring
devices,
consequently
careful
analysis
additional
procedures
a
proper
understanding
phenomena.
1
Introduction
2
Brief
History
Mechanochemistry
3
Milling
Equipment
Reaction
Parameters
4
Attributes
That
Propelled
Its
Present
Renaissance
4.1
Enormous
Attention
Being
Presently
Paid
Sustainable
Chemistry
4.2
Reduced
Energy
Consumption
4.3
Additive-Based
4.4
Handling
Insoluble
Reactants
4.5
‘Impossible’
Reactions
Are
Successful
4.6
Air-
Water-Sensitive
Reagents
Ball
5
Salient
Developments
Mechanochemical
Activation
Synthetic
Organic
5.1
Amino
Acid
Peptide
Mechanosynthesis
5.2
Asymmetric
Synthesis
Organocatalysis
under
Ball-Milling
Conditions
5.3
Mechanoenzymology
5.4
Multicomponent
Activated
5.5
Heterocycles
Modification
6
Future
Directions
6.1
Scaling-Up
Protocols
6.2
Temperature-Controlled
6.3
Understanding
Transformations
6.4
Emerging
Techniques
7
Conclusions
Energy & environment materials,
Journal Year:
2024,
Volume and Issue:
7(5)
Published: Jan. 22, 2024
Piezo‐photocatalysis
could
coalesce
the
advantages
of
mechanical
vibration
and
solar
energy
perfectly
to
achieve
high‐efficiency
catalytic
activity.
Herein,
quintessential
piezoelectric
material
CdS
nanowires
with
different
aspect
ratios
are
precisely
constructed
applied
for
piezo‐photocatalytic
reduction
U(VI)
first
time.
The
ultrasonic
(60
kHz,
100
W)
induces
potential
generate
a
0.57
eV
A
−1
electric
field,
which
is
added
direction
(010)
as
driving
force
efficiently
separate
photogenerated
charges.
alliance
between
effect
photocatalytic
activity
endows
NW‐3
fastest
rate
under
5
W
LED
irradiation,
relevant
constant
(0.042
min
)
about
12
53.8
times
than
that
ultrasonication.
More
importantly,
93.74%
be
removed
from
natural
uranium
mine
wastewater.
Therefore,
this
piezo‐photocatalysis
system
reduces
easily
separable
(UO
2
)O
·2H
O(s)
provides
valuable
input
disposal
applications
radioactive
wastewater
broadens
horizons
nuclear
utilization
toward
advancement
carbon
neutrality.
Macromolecules,
Journal Year:
2024,
Volume and Issue:
57(7), P. 3131 - 3137
Published: March 25, 2024
In
this
report,
we
demonstrate
that
polymethacrylates
can
undergo
appreciable
depolymerization,
with
mild
conditions
and
without
reactive
end
groups,
using
ball-mill
grinding
(BMG).
For
instance,
the
important
commercial
polymer,
poly(methyl
methacrylate)
(PMMA)
underwent
up
to
41%
depolymerization
monomer
within
8
min
of
grinding.
We
explored
factors
influence
conversion
found
temperature
(heating
only
43
°C),
addition
a
small
amount
liquid
(μL
tert-butyl
alcohol),
ball
number/size
be
most
parameters.
also
applied
method
other
pendent
substituent
extent
depolymerization.
Addition
was
reverse
effects
were
observed
bulk
among
studied,
PMMA
had
lowest
in
one
highest
conversions
slurry.
Notably,
molecular
weight
residual
polymer
is
remarkably
low,
ca.
1
kDa,
demonstrating
excellent
degradation
performance
BMG.
Overall,
work
provides
mechanistic
insight
into
reactions
under
ball-milling
represents
an
step
expanding
BMG
as
tool
for
chemical
recycling
polymethacrylates.
EES Catalysis,
Journal Year:
2024,
Volume and Issue:
2(4), P. 884 - 910
Published: Jan. 1, 2024
Achieving
value-added
transformation
of
chemicals
through
green
catalytic
technology
can
simultaneously
meet
the
market
and
environmental
protection.
This
article
reviews
recent
advances
in
synthesizing
using
piezo-(photo)catalytic
technologies.
Angewandte Chemie International Edition,
Journal Year:
2024,
Volume and Issue:
63(28)
Published: April 30, 2024
Abstract
The
development
of
green
and
efficient
deuteration
methods
is
great
significance
for
various
fields
such
as
organic
synthesis,
analytical
chemistry,
medicinal
chemistry.
Herein,
we
have
developed
a
dehalogenative
strategy
using
piezoelectric
materials
catalysts
in
solid‐phase
system
under
ball‐milling
conditions.
This
non‐spontaneous
reaction
induced
by
mechanical
force.
D
2
O
can
serve
both
deuterium
source
an
electron
donor
the
transformation,
eliminating
need
additional
stoichiometric
exogenous
reductants.
A
series
(hetero)aryl
iodides
be
transformed
into
deuterated
products
with
high
incorporation.
method
not
only
effectively
overcomes
existing
synthetic
challenges
but
also
used
labelling
drug
molecules
derivatives.
Bioactivity
experiments
molecule
suggest
that
D‐ipriflavone
enhances
inhibitory
effects
on
osteoclast
differentiation
BMDMs
vitro
.
Nature Communications,
Journal Year:
2024,
Volume and Issue:
15(1)
Published: July 22, 2024
Abstract
Polymer
materials
suffer
mechano-oxidative
deterioration
or
degradation
in
the
presence
of
molecular
oxygen
and
mechanical
forces.
In
contrast,
aerobic
biological
activities
combined
with
stimulus
promote
tissue
regeneration
repair
various
organs.
A
synthetic
approach
which
energy
synergistically
initiate
polymerization
will
afford
similar
robustness
polymeric
materials.
Herein,
mechanochemical
reversible-deactivation
radical
was
developed
by
design
an
organic
mechano-labile
initiator
converts
into
activators
response
to
ball
milling,
enabling
reaction
proceed
air
low-energy
input,
operative
simplicity,
avoidance
potentially
harmful
solvents.
addition,
this
not
only
complements
existing
methods
access
well-defined
polymers
but
also
has
been
successfully
employed
for
controlled
(meth)acrylates,
styrenic
monomers
solid
acrylamides
as
well
synthesis
polymer/perovskite
hybrids
without
solvent
at
room
temperature
are
inaccessible
other
means.
Chemistry - A European Journal,
Journal Year:
2024,
Volume and Issue:
30(47)
Published: June 18, 2024
Mechanochemical
reactions,
achieved
through
milling,
grinding,
or
other
mechanical
actions,
have
emerged
as
a
solvent-free
alternative
to
traditional
solution-based
chemistry.
Mechanochemistry
not
only
provides
the
opportunity
eliminate
bulk
solvent
use,
reducing
waste
generation,
but
also
unveils
new
reaction
strategy
which
enables
realization
of
reactions
previously
inaccessible
in
solution.
While
majority
organic
facilitated
by
force
traditionally
follow
two-electron
transfer
pathways
similar
their
counterparts,
field
mechanochemically
induced
single-electron
(SET)
has
witnessed
rapid
development.
This
review
outlines
examples
mechanochemical
SET
process,
focusing
on
reagents
that
initiate
SET,
thereby
positioning
mechanochemistry
burgeoning
within
realm
Organic Letters,
Journal Year:
2024,
Volume and Issue:
26(20), P. 4240 - 4245
Published: May 14, 2024
Mechanoredox
chemistry
is
a
rapidly
evolving
field
at
the
intersection
of
mechanical
forces
and
chemical
reactions.
Herein,
we
have
reported
vicinal
dibromination
unsaturated
hydrocarbons
using
piezoelectric
material
(Li2TiO3)
as
redox
catalyst.
Furthermore,
reaction
can
be
efficiently
scaled
up
to
10
mmol
performed
under
an
air
atmosphere
room
temperature
without
solvents
or
external
reductants,
Li2TiO3
reused
multiple
times
structural
change.
