Journal of Medicinal Chemistry,
Journal Year:
2024,
Volume and Issue:
67(15), P. 13383 - 13391
Published: July 26, 2024
Photodynamic
therapy
(PDT)
is
a
promising
anticancer
method
due
to
its
noninvasive
features,
high
efficiency,
and
superior
accuracy.
The
activated
near-infrared
upconversion
photosensitizer
has
tissue
penetration
depth
could
be
explicitly
released
with
minimal
side
effects.
Therefore,
we
designed
synthesized
series
of
Br-substituted
compounds
(NFh-Br)
based
on
the
hemicyanine
dye.
heavy
atomic
effect
improves
generation
1O2
luminous
efficiency.
Especially,
NFh-Br11
exhibited
an
excellent
rate
under
808
nm
excitation
effectively
killed
tumor
cells
in
vitro,
alkaline
phosphatase
(ALP)-activatable
(NFh-ALP)
was
obtained
by
modifying
NFh-Br11.
NFh-ALP
ALP
release
NFh-Br11,
which
induces
apoptosis
outstanding
effects
vitro
vivo.
This
work
provide
strategy
for
designing
activatable
photosensitizers.
ACS Nano,
Journal Year:
2025,
Volume and Issue:
unknown
Published: April 16, 2025
Inherent
self-defense
pathways
within
malignant
tumors
include
the
action
of
heat
shock
proteins
(HSPs)
and
often
impede
photothermal
therapy
efficacy.
Interestingly,
HSP40
inhibits
glycolysis
disrupts
mitochondrial
function
to
overcome
tumor
mechanisms
exhibits
a
tumor-suppressive
effect.
Reactive
oxygen
species
(ROS),
especially
hydroxyl
radicals,
generated
by
type-I
photodynamic
inhibit
adenosine
triphosphate
(ATP)
production
lead
ATP-independent
overexpression
during
stress.
However,
regulatory
linking
radicals
induce
expression
remain
unclear.
Therefore,
it
is
imperative
elucidate
underlying
mechanism
governing
induction
stress
explore
its
potential
as
promising
therapeutic
strategy
against
development.
By
strategically
modifying
aza-BODIPY
structure
precisely
distribute
excited-state
energy,
we
have
demonstrated
that
specific
correlated
with
proportion
rather
than
their
individual
levels.
This
orchestrated
NIR-II
photosensitizer-based
nanoparticles
reduced
disrupted
ATP
production,
driving
cell
apoptosis
amplifying
efficacy
therapy.
Silencing
compensation
HSPs
under
ROS
represent
effective
for
overcoming
in
cancer
Bioconjugate Chemistry,
Journal Year:
2023,
Volume and Issue:
34(8), P. 1387 - 1397
Published: Aug. 3, 2023
An
ideal
photosensitizer
for
photodynamic
therapy
should
not
only
possess
high
reactive
oxygen
species
(ROS)
generation
efficiency
but
also
maximize
utilization
of
the
in
situ
produced
ROS
species,
where
latter
is
closely
related
to
its
intracellular
location.
However,
rational
design
such
without
tedious
conjugation
procedures
remains
a
grand
challenge.
Here,
we
report
one-pot
preparation
carbon
dots
(CDs)-based
from
levofloxacin
and
neutral
red
featuring
both
1O2
quantum
yield
(φΔ
=
38.85%)
superior
RNA
selectivity.
Moreover,
φΔ
value
shows
further
40%
improvement
reaches
54.33%
response
binding.
Owing
these
combined
attributes,
CDs
could
exert
great
damage
cellular
system
(termed
RNA-destroyer)
under
extremely
low
dosage
light
irradiation
(15
mW
cm–2,
1
min).
It
induces
pyroptotic
cell
death
causes
rapid
release
different
cytokines
that
served
as
molecular
markers
immunotherapy.
This
work
represents
meticulously
designed
with
via
good
organization
photosensitive
targeting
modularity.
it
first
CDs-based
pyroptosis
inducer
best
our
knowledge.
ACS Applied Materials & Interfaces,
Journal Year:
2024,
Volume and Issue:
16(45), P. 61739 - 61750
Published: Oct. 30, 2024
Type
I
photodynamic
therapy
(PDT)
exhibits
outstanding
therapeutic
effects
in
hypoxic
environments
tumors,
but
the
design
of
type
photosensitizers
(PSs),
especially
those
with
simple
structures
dramatic
properties,
remains
a
challenge.
Herein,
we
report
strategy
for
developing
PSs
one
molecule
afterglow
luminescence.
As
proof
concept,
4,4-difluoro-4-bora-3a,4a-diaza-s-indacene
(BODIPY)
PS
(BIP)
bearing
water-soluble
poly(ethylene
glycol)
(mPEG550)
chains
is
synthesized,
and
BIP
can
self-assemble
into
nanoparticles
(BIPNs).
Interestingly,
BIPNs
exhibit
an
O2•--triggered
luminescence,
which
scarce,
BODIPY
derivatives.
demonstrate
dominant
PDT
at
ultralow
dose
under
both
normoxic
environments,
significantly
inhibit
tumor
growth
irradiation.
This
work
highlights
high-performance
luminescence
excellent
effects,
underscoring
significant
potential
versatile
clinical
theranostics.
Advanced Functional Materials,
Journal Year:
2024,
Volume and Issue:
unknown
Published: Nov. 22, 2024
Abstract
Photodynamically
induced
cell
immunogenic
death
has
emerged
as
an
effective
antitumor
strategy
because
of
its
capacity
to
stimulate
anti‐tumor
immunity
for
eliminating
primary
tumors
and
metastases.
Considering
that
the
short‐lived
reactive
oxygen
species
(ROS)
anoxic
tumor
microenvironment
restrict
efficacy
conventional
photodynamic
therapy
(PDT),
a
molecular
framework
near‐infrared
(NIR)
type
I
aggregation‐induced
emission
(AIE)
photosensitivities
with
tunable
sub‐organelles
(including
membranes,
mitochondria,
lipid
drops,
lysosomes,
endoplasmic
reticulum)
targeting
ROS
in
precisely
regulated
subcellular
locations
are
designed.
Subsequent
studies
have
discovered
under
660
nm
laser
irradiation,
membrane‐targeted
TCF‐Mem
can
effectively
induce
pyroptosis
cancer
cells,
fully
enhancing
vivo
preventive
vaccine
model.
Additionally,
PDT
eradicate
and,
more
importantly,
inhibit
growth
distant
through
vitro
actions,
thereby
obtaining
specific
immunity.
This
study
provides
novel
rational
design
photosensitive
NIR
AIE
offers
new
perspective
innovative
PDT‐based
immune
enhancement
strategies.
Journal of Medicinal Chemistry,
Journal Year:
2024,
Volume and Issue:
67(15), P. 13383 - 13391
Published: July 26, 2024
Photodynamic
therapy
(PDT)
is
a
promising
anticancer
method
due
to
its
noninvasive
features,
high
efficiency,
and
superior
accuracy.
The
activated
near-infrared
upconversion
photosensitizer
has
tissue
penetration
depth
could
be
explicitly
released
with
minimal
side
effects.
Therefore,
we
designed
synthesized
series
of
Br-substituted
compounds
(NFh-Br)
based
on
the
hemicyanine
dye.
heavy
atomic
effect
improves
generation
1O2
luminous
efficiency.
Especially,
NFh-Br11
exhibited
an
excellent
rate
under
808
nm
excitation
effectively
killed
tumor
cells
in
vitro,
alkaline
phosphatase
(ALP)-activatable
(NFh-ALP)
was
obtained
by
modifying
NFh-Br11.
NFh-ALP
ALP
release
NFh-Br11,
which
induces
apoptosis
outstanding
effects
vitro
vivo.
This
work
provide
strategy
for
designing
activatable
photosensitizers.
