Synthesis of N-Heteroaryl C-Glycosides and Polyhydroxylated Alkanes with Diaryl Groups from Unprotected Sugars DOI Creative Commons
Yixuan Liu, Jilai Wu,

Likai Zhou

et al.

ACS Omega, Journal Year: 2024, Volume and Issue: 9(50), P. 49618 - 49624

Published: Nov. 27, 2024

HCl-catalyzed

Language: Английский

Radical Alkylation and Protonation Induced anti-Markovnikov Hydroalkylation of Unactivated Olefins via Cobalt Catalysis DOI
Shanshan Huang, Xiaoyang Chen,

Zhangwenyi Xu

et al.

Chemical Communications, Journal Year: 2024, Volume and Issue: 60(69), P. 9258 - 9261

Published: Jan. 1, 2024

A cobalt catalyzed reductive hydroalkylation of unactivated olefins with anti-Markovnikov selectivity was reported to access complex alkyl amides.

Language: Английский

Citations

0
Palladium‐Catalyzed Directing‐group‐mediated γ‐C(sp3)‐H Glycosylation for Synthesis of C‐Alkyl Glycosides DOI

Q. Zhong,

Changyue Yu, Jinlin Wang

et al.

Advanced Synthesis & Catalysis, Journal Year: 2024, Volume and Issue: unknown

Published: Aug. 29, 2024

Abstract C ‐alkyl glycosides play a crucial role in various bioactive compounds. However, the synthesis of poses significant challenges, particularly through C( sp 3 )−H glycosylation. Here, we report set reactions for constructing directing‐group‐mediated functionalization unactivated γ ‐C( bonds under mild conditions. These not only achieve high regioselectivity and stereoselectivity glycosylation, but also exhibit wide substrate scope. They are compatible with both arene alkane substrates, as well natural unnatural amino acid substrates. Mechanistic studies have shown that directing‐group 8‐aminoquinoline (AQ) picolinamide (PA) may affect chirality β ‐carbon L ‐valine sterically favorable trans ‐palladacycle intermediate, resulting ( R ) or S configuration glycosylated acid, respectively. promising to provide convenient powerful tool carbohydrate‐based drugs future.

Language: Английский

Citations

0
Cobalt-Catalyzed Stereoselective Synthesis of Chiral Gem-Difluorocyclopropanes with Vicinal Stereocenters DOI

Bingxue Liu,

Deguang Liu, Cong Niu

et al.

Organic Chemistry Frontiers, Journal Year: 2024, Volume and Issue: 11(23), P. 6617 - 6626

Published: Jan. 1, 2024

We present a cobalt-catalyzed regio-, diastereo-, and enantioselective hydroalkylation of gem -difluorocyclopropenes, accessing chiral -difluorocyclopropanes with vicinal stereocenters.

Language: Английский

Citations

0
Cobalt-Catalyzed Highly α-Stereoselective Glycosylation of Glycals DOI

Liu Xingle,

Qiu-Qi Mu,

Li Xu

et al.

Organic Letters, Journal Year: 2024, Volume and Issue: unknown

Published: Nov. 22, 2024

Following the satisfactory catalytic performance of cobalt in

Language: Английский

Citations

0
Synthesis of N-Heteroaryl C-Glycosides and Polyhydroxylated Alkanes with Diaryl Groups from Unprotected Sugars DOI Creative Commons
Yixuan Liu, Jilai Wu,

Likai Zhou

et al.

ACS Omega, Journal Year: 2024, Volume and Issue: 9(50), P. 49618 - 49624

Published: Nov. 27, 2024

HCl-catalyzed

Language: Английский

Citations

0