Processable Circularly Polarized Luminescence for the Synthesis of Chiral Plasmonic Nanoparticles DOI Creative Commons
Zhiyu Wang, Anran Li,

Qinxuan Cao

et al.

Advanced Optical Materials, Journal Year: 2024, Volume and Issue: unknown

Published: Oct. 25, 2024

Abstract Circularly polarized light is previously shown as a chiral bias to enable the synthesis of plasmonic nanomaterials through light‐matter interactions. The traditional approach for circularly generation relies on “top‐down” by removing undesired polarization optics, which suffers from energy loss and compatibility issues. An alternative develop phosphors that emit efficient luminescence (CPL). However, most materials fail produce processable CPL with both high quantum yield dissymmetry factors, let alone nanomaterials. Herein, liquid‐crystal‐templated framework developed assemble halide perovskite nanocrystals, CsPbX 3 (X = Cl, Br, I), achieved record‐high figure merit (FM) three primary colors (Red, Green, Blue). fidelity further demonstrated in gold nanoparticles, where five‐fold increase optical activity achieved.

Language: Английский

Advanced Polymeric Nanoparticles for Cancer Immunotherapy: Materials Engineering, Immunotherapeutic Mechanism and Clinical Translation DOI Open Access

Wencong Jia,

Ye Wu, Yujie Xie

et al.

Advanced Materials, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 10, 2025

Abstract Cancer immunotherapy, which leverages immune system components to treat malignancies, has emerged as a cornerstone of contemporary therapeutic strategies. Yet, critical concerns about the efficacy and safety cancer immunotherapies remain formidable. Nanotechnology, especially polymeric nanoparticles (PNPs), offers unparalleled flexibility in manipulation‐from chemical composition physical properties precision control nanoassemblies. PNPs provide an optimal platform amplify potency minimize systematic toxicity broad spectrum immunotherapeutic modalities. In this comprehensive review, basics polymer chemistry, state‐of‐the‐art designs from physicochemical standpoint for encompassing vaccines, situ vaccination, adoptive T‐cell therapies, tumor‐infiltrating cell‐targeted antibodies, cytokine therapies are delineated. Each immunotherapy necessitates distinctively tailored design strategies nanoplatforms. The extensive applications PNPs, investigation their mechanisms action enhanced particularly focused on. profiles clinical research progress discussed. Additionally, forthcoming developments emergent trends nano‐immunotherapeutics poised transform treatment paradigms into clinics explored.

Language: Английский

Citations

4
Dynamic Circularly Polarized Luminescence Switching of Metal–Organic Supramolecular Polymers Directed by the Competition of Solvent-Assisted Nucleation and Thermal Nucleation DOI

Menglu He,

Hao Sun, Liangliang Zhu

et al.

Chemistry of Materials, Journal Year: 2024, Volume and Issue: 36(5), P. 2508 - 2519

Published: Feb. 28, 2024

It is challenging to precisely regulate the chirality transmission of metal–organic supramolecular polymers (MOSPs) due a poor understanding nucleation pathways during highly dynamic and complex self-assembly process. This work reports circularly polarized luminescence (CPL) switching pyridine Schiff-base cholesterol (2-PMPCC) ZnCl2-based MOSPs with inversion CPL through competition solvent-assisted thermal nucleation. In p-xylene, metal 2-PMPCC·ZnCl2 conducted assembled into metastable twisted nanoribbons Agg I right-handed at 490 nm, which further reverted thermodynamic II left-handed nm. contrast, nanosheet-like III 460 nm in ethanol. Based on nucleation, significant morphology were achieved by tuning temperature cosolvents p-xylene revealed transfer transformation regulated solvent-dependent MOSPs, providing an efficient approach control tunable performances for design chiroptical materials.

Language: Английский

Citations

6
Enantioselective Oral Absorption of Molecular Chiral Mesoporous Silica Nanoparticles DOI Open Access
Yuxin Wang, Lin Zhao, Yibo Dai

et al.

Advanced Materials, Journal Year: 2023, Volume and Issue: 35(49)

Published: Oct. 15, 2023

Inspired by the unique pharmacological effects of chiral drugs in asymmetrical body environments, it is assumed that chirality nanocarriers also a key factor to determine their oral adsorption efficiency, apart from size, shape, etc. Herein, l/d-tartaric acid modified mesoporous silica nanoparticles (l/d-CMSNs) are fabricated via one-pot cocondensation method, and focused on whether will be benefited chirality. It found l-CMSN performed better sequential absorption processes, including mucus permeation, mucosa bio-adhesion, cellular uptake, intestinal transport gastrointestinal tract (GIT) retention, than those d-chiral (d-CMSN), racemic (dl-CMSN), achiral (MSN) counterparts. The multiple recognition mechanisms experimentally theoretically demonstrated following simple differential biointerfaces, wherein electrostatic interaction dominant energy. During delivery task, l-CMSN, which proven stable, nonirritative, biocompatible, biodegradable, efficiently absorbed into blood (1.72-2.05-fold higher other nanocarriers), helps loaded doxorubicin (DOX) achieve (2.32-27.03-times samples), satisfactory bioavailability (449.73%) stronger antitumor effect (up 95.43%). These findings validated role determining biological fate nanocarriers.

Language: Английский

Citations

11
Chiral Polymers Based on Vinyl[2.2]paracyclophane and Their Application as CPL Emitters DOI Open Access
Henrik Tappert, Emma V. Puttock,

Jhon Sebastian Oviedo Ortiz

et al.

Polymers, Journal Year: 2025, Volume and Issue: 17(8), P. 1070 - 1070

Published: April 16, 2025

Chiral molecules are integral to various biological and artificial systems, influencing processes from chemical production optical activities. In this study, we explore the potential of chiral vinyl[2.2]paracyclophane (vinyl-PCP) as a monomer for synthesis homopolymers copolymers with styrene. We achieved polymerization through anionic, cationic, radical methods. The resulting polymers demonstrated significant properties, even in small fractions monomer. Further, developed polymerizable vinyl emitter 10-(4-(4,6-diphenyl-1,3,5-triazin-2-yl)phenyl)-9,9-dimethyl-9,10-dihydroacridine (DMAC-TRZ) two-step an overall yield 48%. Copolymerization vinyl-PCP resulted emissive that circularly polarized luminescence (CPL) properties. inclusion PCP monomer, acting both host material source chirality CPL, enhanced photoluminescence quantum (PLQY) 47.2% N2 at 5–10% content, compared 26.8% pure polymer. CPL-active show clear mirror-image Cotton effects 240 nm 267 dissymmetry factors around +2 × 10−4 −1 10−4. This self-hosting effect monomers underscores advanced functional materials communication bio-responsive imaging.

Language: Английский

Citations

0
[2.2]Paracyclophane Materials – Status and Perspectives DOI Creative Commons
Henrik Tappert, Stefan Braese

Macromolecular Rapid Communications, Journal Year: 2025, Volume and Issue: unknown

Published: April 28, 2025

Abstract [2.2]Paracyclophane (PCP) has emerged as a versatile building block in polymer science owing to its unique bicyclic structure, rigidity, and inherent chirality. To promote this the broader public highlight versatility, paper provides concise overview of recent advancements PCP‐based polymers, including their synthesis, structural features, diverse applications. Functionalized PCP side chain backbone polymers exhibit remarkable properties, π‐stacking, tunable optoelectronic activity, an easily defined 3D structure. Applications span from advanced coatings using chemical vapor deposition semiconductors emitters, well chiral materials for sensing catalysis. Additionally, incorporation into metal‐organic frameworks opens up new avenues science. These findings PCP's potential drive innovative macromolecule engineering technology solutions.

Language: Английский

Citations

0
Access to [2.2]Paracyclophane-Fused N-Heterocycles via Palladium-Catalyzed C–H Activation and Cyclization of [2.2]Paracyclophaneacylhydrazones with Vinyl Azides DOI

Biao Nie,

Guodong Sun, Zhongqing Wang

et al.

Organic Letters, Journal Year: 2025, Volume and Issue: unknown

Published: May 13, 2025

A novel protocol for the synthesis of [2.2]paracyclophane-fused N-heterocycles via palladium-catalyzed C-H activation and cyclization [2.2]paracyclophaneacylhydrazones with vinyl azides has been developed. High regioselectivity control was realized by selective activation/functionalization bond highly rigid [2.2]paracyclophanes. broad range isoquinolinophane derivatives were prepared in sole good functional group tolerance, which would be difficult to synthesize other approaches a one-step manner.

Language: Английский

Citations

0
From Molecules to Materials: Collaborative Research at the Chemistry—Materials Science Interface and Lessons Learned in Cyclophane Chemistry DOI Creative Commons
Zahid Hassan, Eli Zysman‐Colman,

Jörg Lahann

et al.

Advanced Functional Materials, Journal Year: 2024, Volume and Issue: unknown

Published: June 12, 2024

Abstract In the spirit of pursuing collaborative research at interface chemistry and materials science for engineering cyclophane‐based functional systems, journey from molecules to a portion accomplishments exploring technologically‐relevant small‐molecule organic emitters, polymer thin films, supra‐sensing through supramolecular host‐guest interactions (molecular self‐assembly) is shared. This report highlights diverse trajectories importance active collaboration within community. It also intended serves young scientists who are committed in interdisciplinary domains. inspires fostering global networks promoting industrial−academic symbiosis that bring innovations education environment curriculum by sharing mutual experiences, knowledge, specialized skills which may cut across several inter‐related disciplines.

Language: Английский

Citations

2
Chemical Evolution and Biological Evaluation of Natural Products for Efficient Therapy of Acute Lung Injury DOI Creative Commons
Chengcheng Fan, Zeyi Zhang, Zhencheng Lai

et al.

Advanced Science, Journal Year: 2023, Volume and Issue: 11(7)

Published: Dec. 21, 2023

Abstract Acute lung injury (ALI) is one of the most common complications in COVID‐19 and also a syndrome acute respiratory failure with high mortality rates, but lacks effective therapeutic drugs. Natural products provide inspiration have proven to be valuable source for bioactive molecule discovery. In this study, chemical evolution natural product Tanshinone IIA (Tan‐IIA) achieve piperidine‐fused scaffold through synthetic route pre‐activation, multi‐component reaction, post‐modification presented. Through biological evaluation, it pinpointed that compound 8b standout candidate remarkable anti‐inflammation anti‐oxidative stress properties, coupled low toxicity. The mechanistic study unveils multifaceted profile shows highly efficient vivo treatment ALI. Therefore, work not only provides an strategy ALI, offers distinctive product‐inspired drug

Language: Английский

Citations

5
AIEE-active dichlorobenzene and chlorobenzene ratiometric fluorescent probe based on [2.2]paracyclophane DOI
Wenzeng Duan,

Wenxue Yu,

Wenjing Liu

et al.

Spectrochimica Acta Part A Molecular and Biomolecular Spectroscopy, Journal Year: 2024, Volume and Issue: 316, P. 124380 - 124380

Published: April 29, 2024

Language: Английский

Citations

0
Linker Chemistry and Connectivity Fine-Tune the Immune Response and Kinetic Solubility of Conjugated NOD2/TLR7 Agonists DOI Creative Commons

Špela Janež,

Samo Guzelj, Žiga Jakopin

et al.

Bioconjugate Chemistry, Journal Year: 2024, Volume and Issue: 35(11), P. 1723 - 1731

Published: Oct. 10, 2024

There is a growing interest in developing novel immune potentiators capable of eliciting cellular response. We tackle this challenge by harnessing the synergistic cross-activation between two innate receptors─the nucleotide-binding oligomerization domain-containing protein 2 (NOD2) and Toll-like receptor 7 (TLR7). Herein, we investigate structure–activity relationship series conjugated NOD2/TLR7 agonists incorporating variety flexible aliphatic, poly(ethylene glycol)-based triazole-featuring linkers. Our findings reveal potent immune-enhancing properties conjugates human primary peripheral blood mononuclear cells, characterized Th1/Th17 polarized cytokine Importantly, demonstrate that both chemistry linker site linkage affect fingerprint kinetic solubility these agonists. These results shed further light on immunostimulatory potential provide insights for designing innovative potentiators.

Language: Английский

Citations

0