An Acid‐Activatable Fluorescent Probe for Sulfur Dioxide in Traditional Chinese Medicines and Living cells DOI
Guan Xi, Liwen Liu,

Peitao Zhou

et al.

Chemistry - An Asian Journal, Journal Year: 2024, Volume and Issue: 19(20)

Published: July 23, 2024

Abstract Excessive sulfur dioxide (SO₂) disturbs physiology of lysosomes causing diseases and threatening human health. A fluorescent probe has been regarded as one the most attractive approaches, which is compatible with living cells possesses high sensitivity. However, probes’ reaction sites are activated before they reach destination. In this work, an acid‐activatable PT1 was synthesized, characterized, used for SO 2 detection. The introduction oxazolines in enables intelligent response to release activation stie derivatives through Michael addition upon exposure acid. vitro studies showed a remarkable selectivity SO₂ than other biothiols limit detection low 62 nM. By using acidic pH‐controlled fluorescence responsiveness SO₂, precise spatiotemporal identification lysosomal fluctuations successfully performed. Furthermore, can be applied monitoring traditional Chinese medicines.

Language: Английский

Designing polymersomes with surface-integrated nanoparticles through hierarchical phase separation DOI Creative Commons
Jingxin Shao, Yingtong Luo, Hanglong Wu

et al.

Nature Communications, Journal Year: 2025, Volume and Issue: 16(1)

Published: March 11, 2025

Polymersomes with surface-integrated nanoparticles, in which a smaller sphere is attached to larger capsule, are typically formed through complex processes like membrane deformation, polymerization, or functionalization. This complexity restricts facile application of this unusual topology, for example drug delivery nanomotor science. Our study introduces robust method crafting polymersomes nanoparticles using hierarchical phase separation approach. By co-assembling block copolymers aromatic aggregation-induced emission (AIE) moieties as side chains and photothermal-responsive guest molecules (PTM), spontaneous sequential occur that lead their controlled formation. Polymer-rich liquid droplets form first, followed by internal the molecules, determines formation asymmetric morphology. mechanism elucidated detail liquid-phase transmission cryogenic electron microscopy (LP-TEM cryo-TEM) corroborated theoretical simulations interaction forces between molecules. Finally, potential nanomotors demonstrated. have range applications, but challenging prepare. Here, authors report preparation such

Language: Английский

Citations

3
Shape Transformation of Polymer Vesicles DOI Creative Commons
Wei Li, Shaohua Zhang,

Mingchen Sun

et al.

Accounts of Materials Research, Journal Year: 2024, Volume and Issue: 5(4), P. 453 - 466

Published: March 18, 2024

ConspectusLife activities, such as respiration, are accomplished through the continuous shape modulation of cells, tissues, and organs. Developing smart materials with shape-morphing capability is a pivotal step toward life-like systems emerging technologies wearable electronics, soft robotics, biomimetic actuators. Drawing inspiration from vesicular have been assembled to mimic biological modulation. This would enable understanding cellular adaptation guide design capability. Polymer vesicles by amphiphilic molecules an example remarkable systems. The chemical versatility, physical stability, surface functionality promise their application in nanomedicine, nanoreactor, However, it difficult drive polymer away equilibrium induce transformation due unfavorable energy landscapes caused low mobility chains permeability membrane. Extensive studies past decades developed various methods including dialysis, addition, temperature variation, polymerization, gas exchange, etc., transformation. can now be engineered into variety nonspherical shapes. Despite brilliant progress, most current regarding still lie trial-and-error stage. It grand challenge predict program transformations vesicles. An in-depth deformation pathway facilitate transition stage computing In this Account, we introduce recent progress To provide insightful analysis, divided basic coupled deformation. First, discuss focus on two pathways: oblate prolate pathway. Strategies used trigger different pathways introduced. Second, origin selectivity strategies control selectivity. Third, switch coupling pathways. Last, analyze challenges opportunities We envision that systematic push prediction behaviors nanoparticles complex environments, like blood interstitial tissue, access advanced architecture desirable for man-made applications.

Language: Английский

Citations

11
Polymersome Membrane Engineering with Active Targeting or Controlled Permeability for Responsive Drug Delivery DOI
Anum Kayani, Arsalan Raza,

Jiale Si

et al.

Biomacromolecules, Journal Year: 2023, Volume and Issue: 24(11), P. 4622 - 4645

Published: Oct. 23, 2023

Polymersomes have been extensively investigated for drug delivery as nanocarriers two decades due to a series of advantages including high stability under physiological conditions, simultaneous encapsulation hydrophilic and hydrophobic drugs inside inner cavities membranes, respectively, facile adjustment membrane surface properties, well controlled release through incorporation stimuli-responsive components. Despite these features, polymersome frequently suffer from nontargeting poor permeability. In recent years, polymersomes functionalized more efficient delivery. The shells were explored be modified with diverse active targeting groups improve disease-targeting permeability the was adjusted by components smart transportation encapsulated drugs. Therefore, being polymersome-biointerface, tailorable properties can introduced its carefully modulated engineering. This review elaborates on role membranes platform incorporate versatile features. First, we discuss how functionalization facilitates directional journey sites toward specific diseases, cells, or intracellular organelles via targeting. Moreover, advances in past decade related control are also summarized. We finally future development promote vivo nanocarriers.

Language: Английский

Citations

10
Nonlinear amplification of nano bowl surface concavity on the critical response threshold to biosignals DOI Creative Commons
Xuefeng Li, Liang Xin,

Cuiqin Yang

et al.

Nature Communications, Journal Year: 2024, Volume and Issue: 15(1)

Published: Oct. 8, 2024

Polymer nanoparticles that can sharply sense and detect biological signals in cells are promising candidates for biomedical theranostic nanomaterials. However, the response ability of current polymer assemblies poorly matches requirement trace concentration level (10

Language: Английский

Citations

3
Polymeric Nanoarchitectures: Advanced Cargo Systems for Biological Applications DOI Creative Commons
Yingtong Luo, Yudong Li, Loai K. E. A. Abdelmohsen

et al.

Macromolecular Bioscience, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 21, 2025

Abstract Polymeric nanoarchitectures are crafted from amphiphilic block copolymers through a meticulous self‐assembly process. The composition of these is finely adjustable, bestowing precise control over the characteristics and properties resultant polymeric assemblies. These nanoparticles have garnered significant attention, particularly in realm biological sciences, owing to their biocompatibility, favorable pharmacokinetics, facile chemically modifiable nature. Among myriad nanoarchitectures, micelles polymersomes stand out as frontrunners, exhibiting much potential cargo carrier systems for diverse bio‐applications. This review elucidates design strategies employed assemblies, specifically focusing on polymersomes. Subsequently, it discusses wide‐ranging bio‐applications, spanning drug delivery diagnostics bioimaging artificial cell applications. Finally, reflective analysis will be provided, highlighting current landscape carriers, discussing opportunities challenges that lie ahead. With this review, aimed summarize recent advances assemblies applications biomedical field.

Language: Английский

Citations

0
Polymersome-based Nanomotors: Preparation, Motion Control, and Biomedical Applications DOI Creative Commons
Siyu Song, Han Hao,

Jianhong Wang

et al.

Chemical Science, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 1, 2025

Polymersome-based nanomotors represent a cutting-edge development in nanomedicine, merging the unique vesicular properties of polymersomes with active propulsion capabilities synthetic nanomotors. As structure enclosed by a...

Language: Английский

Citations

0
Review of Shape Transformation Pathways of Polymersomes: Implications for Nanomotor, Biomedicine, and Artificial Cell Mimics DOI
Xurui Zhang, Jan C. M. van Hest, Yongjun Men

et al.

ACS Applied Nano Materials, Journal Year: 2024, Volume and Issue: 7(13), P. 14865 - 14888

Published: June 28, 2024

Polymersomes have been studied for many years since their discovery, and consistently an appealing widely explored research domain. Their inherent benefits, encompassing stability, versatility, load-carrying capacity, deformability, endow them with opportunities to be used in numerous fields of biomedicine, nanocarriers, diagnostics therapeutics. Nevertheless, shape transformation pathways not comprehensively summarized or received adequate scholarly attention. Herein, we summarize typical mechanisms underlying polymersome self-assembly a particular focus on the associated commonly employed self-assembling methods. Moreover, provide succinct overview proposed applications involving applications, enumerate most recent findings this

Language: Английский

Citations

2
Self-healing adhesive hydrogels for sustained ozone release: Enhanced antibacterial properties and improved wound healing DOI

Shanbo Ma,

Conghui Han, Xi Chen

et al.

Journal of Controlled Release, Journal Year: 2024, Volume and Issue: 377, P. 212 - 222

Published: Nov. 20, 2024

Language: Английский

Citations

2
Rational Design of Self-Reporting Polymersomes for the Controlled Release of Sulfur Dioxide DOI

Zhezhe Li,

Yue Zhang, Shuzhen Wang

et al.

ACS Macro Letters, Journal Year: 2024, Volume and Issue: unknown, P. 1691 - 1697

Published: Nov. 27, 2024

As a new member of the gaseous regulators, sulfur dioxide (SO

Language: Английский

Citations

2
Morphological Transformation and Surface Engineering of Glycovesicles Driven by Bioinspired Hydrogen Bonds of Nucleobases DOI
Caiyun Yang, Yixuan Du,

Qiaoran Li

et al.

ACS Macro Letters, Journal Year: 2024, Volume and Issue: 13(4), P. 468 - 474

Published: April 4, 2024

Glycopolymer-based supramolecular glycoassemblies with signal-driven cascade morphological deformation and accessible surface engineering toward bioinspired functional glycomaterials have attracted much attention due to their diverse applications in fundamental practical scenarios. Herein, we achieved the transformation of a nucleobase-containing polymeric glycovesicle through exploiting complementary multiple hydrogen bonds nucleobases. First, synthesized thymine-containing glycopolymers (PGal30-b-PTAm249) are capable self-assembling into well-defined glycovesicles. Several kinds amphiphilic adenine-containing block copolymers neutral, positive, negative charges were engineer glycovesicles between adenine thymine. A transformations from vesicles ruptured tails, worm-like micelles, finally spherical micelles observed via continuously adding polymer Furthermore, charge properties these glyconano-objects can be facilely regulated incorporating various polymers. This work demonstrates potential application unique approach precisely morphology for boosting biological applications.

Language: Английский

Citations

1