Angewandte Chemie,
Journal Year:
2023,
Volume and Issue:
135(50)
Published: Aug. 25, 2023
Abstract
Antimicrobial
resistance,
caused
by
persistent
adaptation
and
growing
resistance
of
pathogenic
bacteria
to
overprescribed
antibiotics,
poses
one
the
most
serious
urgent
threats
global
public
health.
The
limited
pipeline
experimental
antibiotics
in
development
further
exacerbates
this
looming
crisis
new
drugs
with
alternative
modes
action
are
needed
tackle
evolving
adaptation.
Transition
metal
complexes
can
replenish
diminishing
stockpile
drug
candidates
providing
compounds
unique
properties
that
not
easily
accessible
using
pure
organic
scaffolds.
We
spotlight
four
emerging
strategies
harness
these
develop
targeted
antibacterial
agents.
Advanced Materials,
Journal Year:
2024,
Volume and Issue:
36(33)
Published: June 14, 2024
Infectious
diseases
caused
by
bacterial,
viral,
and
fungal
pathogens
present
significant
global
health
challenges.
The
rapid
emergence
of
antimicrobial
resistance
exacerbates
this
issue,
leading
to
a
scenario
where
effective
antibiotics
are
increasingly
scarce.
Traditional
antibiotic
development
strategies
proving
inadequate
against
the
swift
evolution
microbial
resistance.
Therefore,
there
is
an
urgent
need
develop
novel
with
mechanisms
distinct
from
those
existing
antibiotics.
Nanozybiotics,
which
nanozyme-based
antimicrobials,
mimic
catalytic
action
lysosomal
enzymes
in
innate
immune
cells
kill
infectious
pathogens.
This
review
reinforces
concept
nanozymes
provides
comprehensive
summary
recent
research
advancements
on
potential
candidates.
Initially,
nanozybiotics
categorized
based
their
activities,
mimicking
either
oxidoreductase-like
or
hydrolase-like
functions,
thereby
highlighting
superior
combating
then
discusses
progress
treating
infections,
confirming
as
translational
nanozybiotic-based
products,
including
hydrogels,
nanorobots,
sprays,
bandages,
masks,
protective
clothing,
also
considered.
Finally,
current
challenges
future
prospects
nanozybiotic-related
products
explored,
emphasizing
design
capabilities
for
applications.
Small,
Journal Year:
2024,
Volume and Issue:
unknown
Published: Nov. 9, 2024
Bacterial
infection
and
an
excessive
inflammatory
response
are
two
major
factors
that
affect
the
healing
of
infected
wounds.
The
zinc
oxide/copper
sulfide
(ZnO-CuS)
microspheres
(MSs)
developed
in
this
work
can
kill
bacteria
resist
inflammation.
ZnO-CuS
exhibits
different
enzyme-like
activities
depending
on
pH.
In
acidic
environments,
peroxidase-like
(POD-like)
activity
convert
hydrogen
peroxide
(H
Advanced Functional Materials,
Journal Year:
2024,
Volume and Issue:
34(44)
Published: May 27, 2024
Abstract
Biofilm‐associated
infections
pose
complex
challenges
that
require
addressing
the
multifaceted
requirements
of
biofilm
disruption,
bacterial
killing,
and
immunomodulation.
In
this
study,
microenvironment‐adaptive
metallo‐polymeric
nanodecoys
(MPNs)
are
synthesized
through
one‐pot
subcomponent
coordination
in
aqueous
solution,
effectively
eradicating
biofilms
modulating
immune
response.
Within
acidic
microenvironment
biofilms,
positively
charged
MPNs
demonstrated
ability
to
interact
with
eliminate
bacteria
while
facilitating
a
Fenton‐like
reaction
for
efficient
eradication
biofilms.
As
local
shifted
from
neutral
basic
state
during
subsequent
tissue
healing
processes,
adaptively
harness
multiple
properties
bind
pathogen‐associated
molecular
patterns,
scavenge
reactive
oxygen
species,
thereby
response,
alleviating
inflammation,
promoting
healing.
This
study
presents
an
strategy
preparing
enzyme‐mimicking
materials
closely
resemble
natural
metalloenzymes,
offer
alternative
current
antibiotic
treatments
biofilm‐associated
infections.
Journal of the American Chemical Society,
Journal Year:
2024,
Volume and Issue:
146(12), P. 8216 - 8227
Published: March 15, 2024
Bioorthogonal
reactions
provide
a
powerful
tool
to
manipulate
biological
processes
in
their
native
environment.
However,
the
transition-metal
catalysts
(TMCs)
for
bioorthogonal
catalysis
are
limited
low
atomic
utilization
and
moderate
catalytic
efficiency,
resulting
unsatisfactory
performance
complex
physiological
Herein,
sulfur-doped
Fe
single-atom
with
atomically
dispersed
uniform
active
sites
fabricated
serve
as
potent
(denoted
Fe-SA),
which
situ
manipulation
of
cellular
processes.
As
proof
concept,
N6-methyladensoine
(m6A)
methylation
macrophages
is
selectively
regulated
by
mannose-modified
Fe-SA
nanocatalysts
Fe-SA@Man
NCs)
cancer
immunotherapy.
Particularly,
agonist
prodrug
m6A
writer
METTL3/14
protein
(pro-MPCH)
can
be
activated
tumor-associated
macrophage
(TAM)-targeting
Fe-SA@Man,
upregulate
expression
then
reprogram
TAMs
tumor
killing
hypermethylation
modification.
Additionally,
we
find
NCs
exhibit
an
oxidase
(OXD)-like
activity
that
further
boosts
upregulation
polarization
via
producing
reactive
oxygen
species
(ROS).
Ultimately,
reprogrammed
M1
elicit
immune
responses
inhibit
proliferation.
Our
study
not
only
sheds
light
on
design
but
also
provides
new
insights
into
spatiotemporal
modulation
RNA
treatment
various
diseases.
Advanced Materials,
Journal Year:
2024,
Volume and Issue:
36(41)
Published: Aug. 13, 2024
Abstract
Bimetallic
nanostructures
are
promising
candidates
for
the
development
of
enzyme‐mimics,
yet
deciphering
structural
impact
on
their
catalytic
properties
poses
significant
challenges.
By
leveraging
versatility
nanocrystal
aerogels,
this
study
reports
a
precise
control
Au–Pt
bimetallic
structures
in
three
representative
configurations,
including
segregated,
alloy,
and
core–shell
structures.
Benefiting
from
synergistic
effect,
these
aerogels
demonstrate
improved
peroxidase‐
glucose
oxidase‐like
performances
compared
to
monometallic
counterparts,
unleashing
tremendous
potential
catalyzing
cascade
reaction.
Notably,
segregated
aerogel
shows
optimal
activity,
which
is
2.80
3.35
times
higher
than
that
alloy
variants,
respectively.
This
enhanced
activity
attributed
high‐density
interface
boundaries
within
structure,
foster
greater
substrate
affinity
superior
efficiency.
work
not
only
sheds
light
structure–property
relationship
catalysts
but
also
broadens
application
scope
biosensing
biological
detections.
ACS Nano,
Journal Year:
2024,
Volume and Issue:
18(2), P. 1531 - 1542
Published: Jan. 2, 2024
Nanomedicine
is
promising
for
disease
prevention
and
treatment,
but
there
are
still
many
challenges
that
hinder
its
rapid
development.
A
major
challenge
to
efficiently
seek
candidates
with
the
desired
therapeutic
functions
from
tremendously
available
materials.
Here,
we
report
an
integrated
computational
experimental
framework
alloy
nanoparticles
Materials
Project
library
antibacterial
applications,
aiming
learn
inverse
screening
concept
traditional
medicine
nanomedicine.
Because
strong
peroxidase-like
catalytic
activity
weak
toxicity
normal
cells
material
properties
usage,
implementing
theoretical
prediction
models
of
cytotoxicity
first
conducted
select
candidates.
Then,
based
on
scanning
probe
block
copolymer
lithography
used
verify
refine
results.
Finally,
best
candidate
AuCu3
synthesized
in
solution
performance
over
other
against
S.
aureus
E.
coli.
experimentally
confirmed.
The
results
show
power
accelerating
research
development
nanomedicine,
which
may
inspire
similar
strategies
nanomedicines
future.
Advanced Healthcare Materials,
Journal Year:
2024,
Volume and Issue:
unknown
Published: Oct. 10, 2024
The
World
Health
Organization
has
warned
that
without
effective
action,
deaths
from
drug-resistant
bacteria
can
exceed
10
million
annually,
making
it
the
leading
cause
of
death.
Conventional
antibiotics
are
becoming
less
due
to
rapid
bacterial
drug
resistance
and
slowed
new
antibiotic
development,
necessitating
strategies.
Recently,
materials
with
catalytic/enzymatic
properties,
known
as
nanozymes,
have
been
developed,
inspired
by
natural
enzymes
essential
for
eradication.
Unlike
recent
literature
reviews
broadly
cover
nanozyme
design
biomedical
applications,
this
review
focuses
on
latest
advancements
in
nanozymes
combating
resistance,
emphasizing
their
design,
structural
characteristics,
applications
combination
therapy,
future
prospects.
This
approach
aims
promote
development
especially
towards
clinical
translation.
Angewandte Chemie International Edition,
Journal Year:
2023,
Volume and Issue:
62(50)
Published: Aug. 25, 2023
Antimicrobial
resistance,
caused
by
persistent
adaptation
and
growing
resistance
of
pathogenic
bacteria
to
overprescribed
antibiotics,
poses
one
the
most
serious
urgent
threats
global
public
health.
The
limited
pipeline
experimental
antibiotics
in
development
further
exacerbates
this
looming
crisis
new
drugs
with
alternative
modes
action
are
needed
tackle
evolving
adaptation.
Transition
metal
complexes
can
replenish
diminishing
stockpile
drug
candidates
providing
compounds
unique
properties
that
not
easily
accessible
using
pure
organic
scaffolds.
We
spotlight
four
emerging
strategies
harness
these
develop
targeted
antibacterial
agents.
