Pd(II)‐Catalyzed Formal [5 + 2]‐Carbocyclization of ortho‐Aryl‐Substituted Arylaldehydes with Allylic Alcohols

Advanced Synthesis & Catalysis, Journal Year: 2024, Volume and Issue: unknown

Published: Aug. 22, 2024

Abstract A Pd(II)‐catalyzed formal [5+2] coupling‐cyclization of 2‐arylbenzaldehydes with allylic alcohols has been developed. The method provides an efficient approach to access diaryl‐fused cycloheptene skeletons via traceless α‐amino acid‐assisted C sp 2 −H activation process.

Language: Английский

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Iridium-Catalyzed Asymmetric Hydroarylation of Unactivated Alkenes with Heterobiaryls: Simultaneous Construction of Axial and Central Chirality

Organic Letters, Journal Year: 2024, Volume and Issue: 26(32), P. 6835 - 6840

Published: Aug. 7, 2024

There are only a few examples being reported for the simultaneous control of central chirality and axial because it is more challenging. Herein, we report an iridium-catalyzed asymmetric hydroarylation unactivated alkenes with heterobiaryls to simultaneously construct chirality. The reaction showed broad substrate scope delivered products satisfactory results. results experiments demonstrated that FerroLANE ligand promotes proceed along specific modified Chalk-Harrod mechanism.

Language: Английский

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Theoretical Study on the Mechanism of Ru(II)-Catalyzed Intermolecular [3 + 2] Annulation between o-Toluic Acid and 3,5-Bis(trifluoromethyl)benzaldehyde: Octahedral vs Trigonal Bipyramidal

The Journal of Organic Chemistry, Journal Year: 2024, Volume and Issue: unknown

Published: Sept. 23, 2024

Density functional theory was utilized to investigate the mechanism of Ru(II)-catalyzed aromatic C-H activation and addition aldehydes. The proposed catalytic cycle consists bond activation, aldehyde carbonyl insertion for C-C coupling, lactonization formation final product, product separation, catalyst recovery. Our calculations suggest that Ru(OAc)

Language: Английский

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