Construction of axial and point chirality through Ni-catalyzed sila-cycloaddition reaction via desymmetrization and (dynamic) kinetic resolution DOI
Hua‐Jie Zhu, Minghao Shen,

Jia-Wei Si

et al.

Science China Chemistry, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 6, 2025

Language: Английский

Enantioconvergent and diastereoselective synthesis of atropisomeric hydrazides bearing a cyclic quaternary stereocenter through ternary catalysis DOI Creative Commons
Xia Wang, Shaojie Wang,

Xiaolan Xin

et al.

Chemical Science, Journal Year: 2024, Volume and Issue: 15(33), P. 13240 - 13249

Published: Jan. 1, 2024

The enantioselective and diastereoselective synthesis of atropisomeric hydrazides with defined vicinal central axial chirality via ternary catalysis in a one-pot process is reported.

Language: Английский

Citations

4
Synthesis of N–N Axially Chiral Pyrrolyl-oxoisoindolin via Isothiourea-Catalyzed Acylative Dynamic Kinetic Resolution DOI

Tongtong Wang,

Jun Cao, Xin Li

et al.

Organic Letters, Journal Year: 2024, Volume and Issue: 26(29), P. 6179 - 6184

Published: July 18, 2024

The development of methods for the asymmetric synthesis N-N axial chirality remains elusive and challenging. Here, we disclose a method construction axially chiral pyrrolyl-oxoisoindolins along with central via isothiourea (ITU)-catalyzed acylative dynamic kinetic resolution (DKR). Axial was introduced into DKR hemiaminals first time. This protocol features mild conditions excellent yields enantioselectivities.

Language: Английский

Citations

4
Asymmetric Construction of Functionalized Cyclopenta[b]pyrrolines via Cascade Aza-Piancatelli/Hydroamination Reactions DOI

Xukun Nie,

Sishi Zhong,

Jiaming Zou

et al.

Organic Letters, Journal Year: 2024, Volume and Issue: 26(31), P. 6766 - 6770

Published: July 31, 2024

A chiral Brønsted acid/Pd that cooperatively catalyzed the asymmetric cascade aza-Piancatelli rearrangement/hydroamination of readily accessible alkynyl-functionalized tertiary furylcarbinols with anilines has been developed. This protocol provides expedient access to a variety densely functionalized cyclopenta[b]pyrroline derivatives in high yields excellent enantioselectivities.

Language: Английский

Citations

4
Stereoselective Synthesis of Atropisomeric Amides Enabled by Intramolecular Acyl Transfer DOI Creative Commons
Jack M. Wootton,

Natalie J. Roper,

C. Morris

et al.

Chemical Science, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 1, 2025

A stereoselective strategy to make C–N atropisomeric amides based on intramolecular acyl transfer via a tethered Lewis basic pyridine or tertiary amine group is reported.

Language: Английский

Citations

0
Construction of axial and point chirality through Ni-catalyzed sila-cycloaddition reaction via desymmetrization and (dynamic) kinetic resolution DOI
Hua‐Jie Zhu, Minghao Shen,

Jia-Wei Si

et al.

Science China Chemistry, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 6, 2025

Language: Английский

Citations

0