Journal of Medicinal Chemistry, Journal Year: 2024, Volume and Issue: unknown
Published: Dec. 25, 2024
ER-phagy is a double-edged sword in the occurrence, development, and treatment of cancer; especially, its functions immunotherapy are still unknown. In this work, we designed theranostic Re complex (
Language: Английский
Advanced Science, Journal Year: 2025, Volume and Issue: unknown
Published: Jan. 10, 2025
Abstract The infiltration and excessive polarization of M1 macrophages contribute to the induction persistence low‐grade inflammation in joint‐related degenerative diseases such as osteoarthritis (OA). lipid metabolism dysregulation promotes macrophage by coordinating compensatory pathways inflammatory oxidative stress responses. Here, a self‐assembling, licofelone‐loaded nanoparticle (termed LCF‐CSBN), comprising chondroitin sulfate bilirubin joined an ethylenediamine linker, is developed selectively reprogram activation. LCF‐CSBN internalized via CD44‐mediated endocytosis targets Golgi apparatus accompanied with reactive oxygen species‐responsive release licofelone (LCF, dual inhibitor arachidonic acid metabolism). effectively M2 transition reprogramming apparatus‐related sphingolipid metabolism. Intra‐articularly injected retains joint for up 28 days accumulates into macrophages. Moreover, can attenuate inflammation, stress, cartilage degeneration OA model rats. These findings indicate promising potential lipid‐metabolism‐reprogramming targeted therapy OA.
Language: Английский
Citations
3
Advanced Healthcare Materials, Journal Year: 2024, Volume and Issue: 13(17)
Published: March 14, 2024
The Golgi apparatus (GA) is central in shuttling proteins from the endoplasmic reticulum to different cellular areas. Therefore, targeting GA precisely destroy its through local heat could induce apoptosis, offering a potential avenue for effective cancer therapy. Herein, GA-targeted photothermal agent based on protein anchoring introduced enhanced therapy of tumor modification near-infrared molecular dye with maleimide derivative and benzene sulfonamide. can actively target covalently anchor sulfhydryl proteins, thereby increasing retention within GA. Under laser irradiation, generated by efficiently disrupts situ, leading dysfunction ultimately inducing cell apoptosis. In vivo experiments demonstrate that treat tumors significantly reduce side effects.
Language: Английский
Citations
6
Journal of Medicinal Chemistry, Journal Year: 2024, Volume and Issue: 67(10), P. 8020 - 8042
Published: May 10, 2024
Promising targeted therapy options to overcome drug resistance and side effects caused by platinum(II) drugs for treatment in hepatocellular carcinoma are urgently needed. Herein, six novel multifunctional platinum(IV) complexes through linking agents glycyrrhetinic acid (GA) were designed synthesized. Among them, complex 20 showed superior antitumor activity against tested cancer cells including cisplatin than simultaneously displayed good liver-targeting ability. Moreover, can significantly cause DNA damage mitochondrial dysfunction, promote reactive oxygen species generation, activate endoplasmic reticulum stress, eventually induce apoptosis. Additionally, effectively inhibit cell migration invasion trigger autophagy ferroptosis HepG-2 cells. More importantly, demonstrated stronger tumor inhibition ability or the combo of cisplatin/GA with almost no systemic toxicity A549 xenograft models. Collectively, could be developed as a potential anti-HCC agent treatment.
Language: Английский
Citations
6
Advanced Drug Delivery Reviews, Journal Year: 2024, Volume and Issue: 212, P. 115387 - 115387
Published: Sept. 1, 2024
Language: Английский
Citations
6
Aggregate, Journal Year: 2024, Volume and Issue: unknown
Published: Nov. 22, 2024
ABSTRACT Long‐term in vivo fluorescence analysis is growing into a sparkling frontier gaining deep insights various biological processes. Exploration of such fluorophores with high performance still remains an appealing yet significantly challenging task. In this study, we have elaborately integrated second near‐infrared (NIR‐II) emissive fluorophore the metal Pt self‐assembled prism‐like metallacage M‐DBTP, which enables intravital long‐term tracking through NIR‐II imaging technologies. addition, bioimaging metallacage‐loaded nanoparticles (NPs) indicated extraordinary photographic on mice blood vessels and rapid clearance M‐DBTP NPs from within 7 h. The subsequent transfer to bones retention bone marrow region for up 35 days was revealed by analysis, confirmed distribution metabolism inductively coupled plasma optical emission spectrometer. Moreover, bright them well perform imaging‐guided tumor surgery.
Language: Английский
Citations
4
Biology, Journal Year: 2023, Volume and Issue: 13(1), P. 1 - 1
Published: Dec. 19, 2023
Although the discovery of Golgi apparatus (GA) was made over 125 years ago, only a very limited number therapeutic approaches have been developed to target this complex organelle. The GA serves as modification and transport center for proteins lipids also has more recently emerged an important store some ions. dysregulation functions is implicated in many cellular processes associated with cancer are indeed described biomarkers. This can affect protein modification, localization, secretion, but metabolism, redox status, extracellular pH, matrix structure. Consequently, it directly or indirectly progression. For these reasons, appealing anticancer pharmacological target. Despite this, no drug specifically targeting reached clinic few entered clinical trial stage. Advances nanodelivery may help change scenario by tumor cells and/or through passive, active, physical strategies. article aims examine currently available GA-targeted drugs strategies explored their administration. potential benefits challenges modulating function context therapy discussed.
Language: Английский
Citations
9
Ecotoxicology and Environmental Safety, Journal Year: 2024, Volume and Issue: 285, P. 117073 - 117073
Published: Sept. 26, 2024
Language: Английский
Citations
2
Cell & Bioscience, Journal Year: 2024, Volume and Issue: 14(1)
Published: Oct. 22, 2024
Abstract The Golgi apparatus is the central hub of cellular endocrine pathway and plays a crucial role in processing, transporting, sorting proteins lipids. Simultaneously, it highly dynamic organelle susceptible to degradation or fragmentation under various physiological pathological conditions, potentially contributing development numerous human diseases. Autophagy serves as vital for eukaryotes manage intracellular extracellular stress maintain homeostasis by targeting damaged redundant organelles removal. Recent research has revealed that autophagy mechanisms can specifically degrade components, known Golgiphagy. This review summarizes recent findings on Golgiphagy while also addressing unanswered questions regarding its regulation, aiming advance our understanding disease.
Language: Английский
Citations
2
Engineered Regeneration, Journal Year: 2024, Volume and Issue: unknown
Published: June 1, 2024
Golgi apparatus (GA) is an organelle widely present in eukaryotic cells and involved a variety of cellular physiological activities, including but not limited to protein modification secretion. There increasing evidence that structural or functional disorders the GA are closely associated with occurrence development diseases. As potential therapeutic targets, researchers have developed GA-targeted drug delivery systems (DDS) for disease treatment. Compared traditional therapy, DDS achieves remarkable curative effect high specificity, low dose, reduced resistance side effects, via alterations morphology biosynthesis. Therefore, therapy great clinical significance has broad application prospects. In this review, structure function briefly introduced, mechanisms entering binding classified. Then typical applications diagnosis treatment cancer, cardiovascular diseases, fibrosis, infectious diseases neurodegenerative introduced detail, displaying its At last, bottlenecks future field discussed. It our hope review will inspire GA-based foreseeable future.
Language: Английский
Citations
1
Scientia Sinica Chimica, Journal Year: 2024, Volume and Issue: 54(9), P. 1471 - 1487
Published: Aug. 20, 2024
Citations
0