Preparation of Lipid–Polymer Conjugates by Photoiniferter Polymerization and Application to Cell Surface Modification DOI Open Access
Wenjin Wang, Shengjie Liu,

Yijia Yu

et al.

Journal of Polymer Science, Journal Year: 2024, Volume and Issue: unknown

Published: Nov. 10, 2024

ABSTRACT The growing demand for lipid–polymer conjugates (LPCs) in biomedicine highlights the need efficient synthesis methods. This study presents a novel Y‐type photoiniferter reagent (Lipid‐PIT) with diethyldithiocarbamate group and diacylglycerol group. Lipid‐PIT efficiently initiated polymerization of vinyl monomers such as oligo(ethylene glycol) methacrylate (OEGMA), N , ‐dimethylacrylamide (DMA), tert ‐butyl acrylate (tBA), n ( BA) under UV irradiation at room temperature, yielding LPCs. Proton NMR confirmed presence moieties chain ends. kinetics DMA showed linear increase molecular weight M ) time, polydispersity (Đ) below 1.50, demonstrating high controllability. Moreover, allows creation block copolymers via secondary extension. In vitro assays revealed that LPCs synthesized from OEGMA successfully modified L929 HeLa cell surfaces exhibited good biocompatibility. offers rapid, method LPC promising biomedical applications.

Language: Английский

Photoiniferter Polymerization: Illuminating the History, Ascendency, and Renaissance DOI
Rhys W. Hughes, Megan E. Lott,

Rebecca A. Olson S

et al.

Progress in Polymer Science, Journal Year: 2024, Volume and Issue: 156, P. 101871 - 101871

Published: Aug. 22, 2024

Language: Английский

Citations

9
Photocontrolled radical polymerization for the synthesis of ultrahigh-molecular-weight polymers DOI
Shilong Zhu, Weina Kong,

Shuangqi Lian

et al.

Nature Synthesis, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 10, 2025

Language: Английский

Citations

1
Low-Viscosity Route to High-Molecular-Weight Water-Soluble Polymers: Exploiting the Salt Sensitivity of Poly(N-acryloylmorpholine) DOI Creative Commons
Rory J. McBride,

E. Geneste,

Andi Xie

et al.

Macromolecules, Journal Year: 2024, Volume and Issue: 57(5), P. 2432 - 2445

Published: Feb. 23, 2024

We report a new one-pot low-viscosity synthetic route to high molecular weight non-ionic water-soluble polymers based on polymerization-induced self-assembly (PISA). The RAFT aqueous dispersion polymerization of N-acryloylmorpholine (NAM) is conducted at 30 °C using suitable redox initiator and poly(2-hydroxyethyl acrylamide) (PHEAC) precursor in the presence 0.60 M ammonium sulfate. This relatively low level added electrolyte sufficient salt out PNAM block, while steric stabilization conferred by short salt-tolerant PHEAC block. A mean degree (DP) up 6000 was targeted for NAM conversions (>96%) were obtained all cases. On dilution with deionized water, as-synthesized sterically stabilized particles undergo dissociation afford molecularly dissolved chains, as judged dynamic light scattering 1H NMR spectroscopy studies. DMF GPC analysis confirmed chain extension efficiency precursor, but broad distributions observed PHEAC–PNAM diblock copolymer chains (Mw/Mn > 1.9). has been many other PISA formulations when targeting core-forming block DPs tentatively attributed transfer polymer, which well known polyacrylamide-based polymers. In fact, dispersities are actually desirable if such copolymers be used viscosity modifiers because solution correlates closely Mw. Static studies also conducted, Zimm plot indicating an absolute Mw approximately 2.5 × 106 g mol–1 DP 6000. Finally, it emphasized that leads sulfur content this latter formulation just 23 ppm, minimizes cost, color, malodor associated organosulfur agent.

Language: Английский

Citations

4
Synthesis of Star Polymers with Ultrahigh Molecular Weights and Tunable Dispersities via Photoiniferter Polymerization DOI
Mei Zhang, Steven P. Armes, Zesheng An

et al.

ACS Macro Letters, Journal Year: 2025, Volume and Issue: unknown, P. 306 - 312

Published: Feb. 21, 2025

Simultaneous control over macromolecular chain topology, molecular weight, and dispersity is an important synthetic goal in polymer chemistry. The synthesis of well-defined poly(methyl acrylate) star polymers with ultrahigh weights (>106 g mol-1) tunable dispersities realized for the first time via blue light-controlled photoiniferter polymerization using a tetrafunctional switchable RAFT agent (SRA4). spectroscopic properties activity SRA4 can be reversibly tuned by addition acid/base. For example, protonation 4-toluenesulfonic acid (TsOH) leads to enhanced UV-visible light absorption, faster rate, lower resulting polymer. Star were prepared predicted (Mn ≈ 80-1550 kg (Đ 1.8-1.2) when targeting degrees range 1000-20000 presence varying amounts TsOH. High end-group fidelity such was confirmed one-pot extension experiments, which afforded series pseudoblock copolymers controlled dispersities. Finally, rotational rheology used examine effect dispersity, topology (whether linear or star-shaped) on solution viscosity.

Language: Английский

Citations

0
Enzyme‐Catalyzed Controlled Radical Polymerization DOI Open Access
Ruoyu Li, Zesheng An

Published: March 7, 2025

Language: Английский

Citations

0
The livingness of poly(methyl acrylate) under visible light photoiniferter-RAFT polymerization mediated by trithiocarbonates DOI Creative Commons

Jungwook Lee,

Yonghwan Kwon,

Changhoon Yu

et al.

Polymer Chemistry, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 1, 2025

In this work, we highlight the impact of reaction conditions ( i.e. monomer conversion, time, and light intensity) on stability thiocarbonylthio group-containing polymers by quantification utilizing TG-HPLC.

Language: Английский

Citations

0
Radical Deamination of Primary Amines for Initiation of Controlled Polymerization DOI

Megan E. Driscoll,

Bryce T. Nicholls, Brett P. Fors

et al.

Journal of the American Chemical Society, Journal Year: 2025, Volume and Issue: unknown

Published: April 30, 2025

Selectively initiating controlled polymerizations using common functional groups is a powerful route to synthesizing advanced polymer architectures. Amines are one of the most in small molecules, pharmaceuticals, and biomolecules, thus valuable substituents use for polymerizations. In this study, we present facile initiation radical polymerization from α-carbon primary amine via an electron donor-acceptor (EDA) complex-triggered deamination. Through method, polymers were successfully grafted variety amino acid derivatives. The resulting had good matching between theoretical experimental molar masses, narrow mass distributions (Đ ∼ 1.1-1.2), exceptional α-chain end fidelities. This method was trialed on model dipeptide, demonstrating viability EDA-RAFT synthesis peptide-polymer conjugates.

Language: Английский

Citations

0
Controlled synthesis of polymers in the light of green chemistry DOI
Д. Ф. Гришин, Ivan D. Grishin

Russian Chemical Reviews, Journal Year: 2025, Volume and Issue: 94(4), P. RCR5164 - RCR5164

Published: April 1, 2025

The discovery of reversible deactivation radical polymerization (RDRP), or controlled (CRP) has revolutionized the chemistry synthetic polymers. This strategy opened up way to polymer materials with architecture, composition, and functions. Currently, owing use novel approaches related chain deactivation, gone beyond synthesis. It can be used obtain not only macromolecular organic compounds, but also organic-inorganic hybrid materials, bioconjugates, promising polymers for electronics, energy production, medicine, other high-tech fields. is exceptionally important that some CRP methods have a clear-cut environmental component, since they are focused on compliance most principles green development nature-like processes in targeted synthesis well-defined specified set properties characteristics. review considers particular examples analyzes possible prospects practical application environmentally benign functional A comparative analysis performed classical living wide range monomers (reversible inhibition, addition fragmentation transfer, atom transfer involving transition metal complexes), concept photoredox catalysis, methodology as applied gives above aspects, including procedural details photoinitiation their relationship key principles. In our opinion, this will interest specialists field chemistry, chemists scientists. <br> bibliography includes 242 references.

Language: Английский

Citations

0
Control of Molecular Weight Distribution through Photoresponsive RAFT Polymerization with a Temporal Program-Controlled System DOI

Jie Sui,

Xiaoyu Miao,

Xin Cao

et al.

Polymer, Journal Year: 2024, Volume and Issue: unknown, P. 127863 - 127863

Published: Nov. 1, 2024

Language: Английский

Citations

1
Green Light-Controlled Switchable Photoiniferter Polymerization DOI
Mei Zhang, Steven P. Armes, Zesheng An

et al.

Macromolecules, Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 25, 2024

Isoquinoline-based acid/base switchable RAFT agents (SRAs) were synthesized and used as new photoiniferters for visible light-controlled polymerization. In contrast to commercially available pyridyl-substituted SRAs, isoquinoline-based SRAs absorb green light more strongly, exhibit higher pKa values, offer rates of photolysis. Photoiniferter polymerization was conducted in the presence either blue or at 25 °C. A faster rate observed syntheses using than SRAs. Polymers with controlled molecular weights tunable dispersities prepared varying amounts 4-toluenesulfonic acid. Four pseudoblock poly(methyl acrylate)s dispersity via chain extension experiments. Well-defined diblock copolymers consisting a activated monomer (methyl acrylate) less (N-vinylpyrrolidone) can be relatively low dispersities.

Language: Английский

Citations

1