Ketone Skeletal Modification via a Metallaphotoredox-Catalyzed Deacylation and Acylation Strategy DOI

Ke‐Han He,

Na Jin, J. Paul Chen

et al.

Organic Letters, Journal Year: 2024, Volume and Issue: 26(44), P. 9503 - 9507

Published: Oct. 28, 2024

Herein, we describe a dual catalytic strategy that employs dihydroquinazolinones, derived from ketone analogs, as versatile intermediates for acylation via α C–C cleavage with 2-pyridyl esters, facilitating the efficient synthesis of variety ketones. The reaction accommodates wide range ketones and carboxylic acids, showing tolerance to various functional groups. versatility this synthetic technique is further highlighted through its application in late-stage modification pharmaceuticals biologically active natural products.

Language: Английский

Ketone Skeletal Modification via a Metallaphotoredox-Catalyzed Deacylation and Acylation Strategy DOI

Ke‐Han He,

Na Jin, J. Paul Chen

et al.

Organic Letters, Journal Year: 2024, Volume and Issue: 26(44), P. 9503 - 9507

Published: Oct. 28, 2024

Herein, we describe a dual catalytic strategy that employs dihydroquinazolinones, derived from ketone analogs, as versatile intermediates for acylation via α C–C cleavage with 2-pyridyl esters, facilitating the efficient synthesis of variety ketones. The reaction accommodates wide range ketones and carboxylic acids, showing tolerance to various functional groups. versatility this synthetic technique is further highlighted through its application in late-stage modification pharmaceuticals biologically active natural products.

Language: Английский

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