Exploring Diazo Compounds for the Divergent Electro-Cascade Sequence and S–H Insertion Reaction DOI
Jaswant Kumar, Deepak Sharma, Yaseen Hussain

et al.

Organic Letters, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 12, 2025

We have explored the reactivity of diazo compounds under electrochemical conditions to establish a cascade sequence thiolation/cyclization/reduction reactions. Electrolyzing styryl imides and aryl thiols enables direct access single diastereoisomer 2,5-pyrrolidine-dione-fused thiochromans in good yield mild metal-free conditions. Notably, tunable has been achieved via S–H insertion at center modified reaction Based on experimental evidences, including detection key intermediates computational studies, mechanism for also established.

Language: Английский

Exploring Diazo Compounds for the Divergent Electro-Cascade Sequence and S–H Insertion Reaction DOI
Jaswant Kumar, Deepak Sharma, Yaseen Hussain

et al.

Organic Letters, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 12, 2025

We have explored the reactivity of diazo compounds under electrochemical conditions to establish a cascade sequence thiolation/cyclization/reduction reactions. Electrolyzing styryl imides and aryl thiols enables direct access single diastereoisomer 2,5-pyrrolidine-dione-fused thiochromans in good yield mild metal-free conditions. Notably, tunable has been achieved via S–H insertion at center modified reaction Based on experimental evidences, including detection key intermediates computational studies, mechanism for also established.

Language: Английский

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