ChemSusChem,
Journal Year:
2024,
Volume and Issue:
unknown
Published: Oct. 15, 2024
We
report
the
first
metal-
and
catalyst-free
protocol
for
facile
cross-coupling
of
aryl
halides
towards
C-B,
C-P
C-S
bonds
under
solid-state
ball
milling
conditions
via
UV
light
irradiation.
The
reactions
can
be
performed
in
absence
bulk
solvents
at
room
temperature
a
mixer
mill,
yielding
up
to
99
%
being
tolerant
various
functionalized
(X=I
or
Br).
Furthermore,
we
developed
novel
photoreactor
design
increasing
intensity.
With
this
could
demonstrate
that
our
surpasses
classical
solvent
based
as
well
purely
mechanochemical
approaches
terms
green
metrics
energy
efficiency.
Chemistry - Methods,
Journal Year:
2025,
Volume and Issue:
unknown
Published: Jan. 31, 2025
Abstract
In
its
ongoing
development,
mechanochemistry
is
becoming
equipped
with
additional
energy
inputs
such
as
light.
this
work
we
demonstrate
a
proof‐of‐principle
setup
for
real‐time
in
situ
Raman
monitoring
of
photomechanochemical
reactions.
Using
photoisomerization
azobenzenes,
and
photolysis
adamantane
diazirine
model
reactions,
show
that
multiple
cycles
can
be
performed
monitored
ball
mill,
highlight
reaction
selectivity
achieved
by
photomechanochemistry.
The Journal of Organic Chemistry,
Journal Year:
2025,
Volume and Issue:
unknown
Published: April 10, 2025
An
environmentally
friendly
and
practical
method
for
the
synthesis
of
various
vinyl
sulfones
was
developed
through
direct
sulfonylation
alkenyl
sulfonium
salts
with
sulfinic
acids.
The
reaction
effectively
triggered
by
combined
actions
milling,
sunlight,
photocatalysts
under
solvent-free
conditions,
offering
advantages
such
as
a
short
time
(5-10
min),
room
temperature,
straightforward
workup
procedure.
Preliminary
mechanistic
studies
suggested
that
sulfonyl
radical
may
be
involved
in
this
mechanophotocatalytic
transformation
process.
Nature Communications,
Journal Year:
2025,
Volume and Issue:
16(1)
Published: April 28, 2025
Photocatalysis
has
greatly
advanced
in
organic
synthesis
but
still
confronts
challenges,
including
light
attenuation
reaction
media
and
excessive
solvent
utilization.
These
issues
lead
to
inefficiencies,
particularly
heterogeneous
cloudy
mixtures
scaling-up
applications.
Integrating
photocatalysis
with
mechanochemistry
offers
a
nascent
promising
solution
these
challenges.
Herein,
we
present
scalable
photo-mechanochemical
platform
that
combines
visible-light
Resonant
Acoustic
Mixing
(RAM),
enabling
efficient
cross-coupling
reactions
under
solvent-minimised
conditions.
This
approach
demonstrates
broad
substrate
tolerance,
accommodating
variety
of
aryl
(hetero)
halides
N-,
O-,
P-,
S-nucleophiles.
The
protocol
supports
scaling
up
300
mmol,
representing
1500-fold
increase,
while
maintaining
exceptionally
low
catalyst
loading
achieving
9800
turnover
numbers
(TON).
generality
this
is
further
validated
by
its
applicability
other
synthetic
transformations.
Organic Chemistry Frontiers,
Journal Year:
2025,
Volume and Issue:
unknown
Published: Jan. 1, 2025
A
general
method
for
accessing
α,β-unsaturated
ketones
through
visible-light
or
sunlight
photoredox-catalyzed
β-selective
acylation
of
alkenes
has
been
developed.
Beilstein Journal of Organic Chemistry,
Journal Year:
2025,
Volume and Issue:
21, P. 458 - 472
Published: March 3, 2025
Photomechanochemistry,
i.e.,
the
merger
of
light
energy
and
mechanical
forces,
is
emerging
as
a
new
trend
in
organic
synthesis,
enabling
unique
reactivities
fleeting
excited
states
under
solvent-minimized
conditions.
Despite
its
transformative
potential,
field
faces
significant
technological
challenges
that
must
be
addressed
to
unlock
full
capabilities.
In
this
Perspective,
we
analyze
selected
examples
showcase
available
technologies
combine
including
manual
grinding,
vortex
shaker
mixing,
rod
milling,
ball
milling.
By
examining
advantages
limitations
each
approach,
aim
provide
an
overview
current
state
synthetic
photomechanochemistry
identify
opportunities
for
future
advancements
rapidly
evolving
area
research.
RSC Mechanochemistry,
Journal Year:
2024,
Volume and Issue:
unknown
Published: Nov. 8, 2024
Ball-milling
allowed
the
efficient
preparation
of
ruthenium
complexes
with
photoredox
properties.
With
a
transparent
and
chemically
resistant
milling
jar
in
epoxy
resin,
photoreductive
dehalogenation
was
realized
efficiently
solventless
manner.
Chemistry - A European Journal,
Journal Year:
2024,
Volume and Issue:
unknown
Published: Oct. 22, 2024
Abstract
Organic
synthesis
has
historically
relied
on
solution‐phase,
polar
transformations
to
forge
new
bonds.
However,
this
paradigm
is
evolving,
propelled
by
the
rapid
evolution
of
radical
chemistry.
Additionally,
organic
witnessing
a
simultaneous
resurgence
in
mechanochemistry,
formation
bonds
solid‐state,
further
contributing
shift
status
quo.
The
aforementioned
advances
chemistry
have
predominantly
occurred
solution
phase,
while
majority
mechanochemical
feature
transformations.
Herein,
we
discuss
rapidly
advancing
area
synthesis:
reactions.
Solid‐state
reactions
offer
improved
green
metrics,
better
reaction
outcomes,
and
access
intermediates
products
that
are
difficult
or
impossible
reach
solution.
This
review
explores
these
context
small
molecule
synthesis,
from
early
findings
current
state‐of‐the‐art,
underscoring
pivotal
role
solid‐state
likely
play
sustainable
chemical
synthesis.
