Journal of the American Chemical Society, Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 24, 2024

Herein, we report a method for enantioselective vinylogous addition of enones to alkoxyallenes enabled by synergistic borane/palladium catalysis. The inductive effect provided borane coordination the ketone was essential closing gap between conditions needed generation dienolate and those initiation palladium catalytic cycle protonation metal catalyst. Furthermore, accomplished first example stereodivergent synthesis with chiral borane/transition-metal catalysts.

Language: Английский