Data-Driven Discovery of a New Fluorescent BASHY Dye for Bioimaging DOI Creative Commons
João M. J. M. Ravasco,

João Felicidade,

Maria V. Pinto

et al.

JACS Au, Journal Year: 2024, Volume and Issue: 4(11), P. 4212 - 4222

Published: Nov. 7, 2024

Fluorescent molecules play a crucial role in biomedicine by facilitating the visualization and tracking of biological processes with sensitivity specificity. However, tailoring their structure to meet demands live cell

Language: Английский

PyrAtes: Modular Organic Salts with Large Stokes Shifts for Fluo‐rescence Microscopy DOI Creative Commons
Iakovos Saridakis, Margaux Riomet, Oliver John V. Belleza

et al.

Angewandte Chemie International Edition, Journal Year: 2024, Volume and Issue: 63(19)

Published: April 3, 2024

Abstract The deployment of small‐molecule fluorescent agents plays an ever‐growing role in medicine and drug development. Herein, we complement the portfolio powerful fluorophores, reporting serendipitous discovery development a novel class with imidazo[1,2‐a]pyridinium triflate core, which term PyrAtes . These fluorophores are synthesized single step from readily available materials (>60 examples) display Stokes shifts as large 240 nm, while also reaching NIR−I emissions at λ max long 720 nm. Computational studies allow platform for prediction Em Furthermore, demonstrate compatibility these live cell imaging HEK293 cells, suggesting potent intracellular markers.

Language: Английский

Citations

5
Fluorescent PyrAte-(S)-citalopram Conjugates Enable Imaging of the Serotonin Transporter in Living Tissue DOI Creative Commons
Oliver John V. Belleza, Iakovos Saridakis, Nadja K. Singer

et al.

Chemical Science, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 1, 2025

We deploy a new class of fluorophores, PyrAtes, in the first-time use small-molecule fluorophore–drug conjugates imaging endogenous SERT ex vivo .

Language: Английский

Citations

0
Rational Design of Pyrido[3,2-b]indolizine as a Tunable Fluorescent Scaffold for Fluorogenic Bioimaging DOI Creative Commons
Sihyeong Yi, Dahham Kim, Wansang Cho

et al.

JACS Au, Journal Year: 2024, Volume and Issue: 4(8), P. 2896 - 2906

Published: June 10, 2024

Novel fluorescent scaffolds are highly demanding for a wide range of applications in biomedical investigation. To meet this demand, the pyrido[3,2-

Language: Английский

Citations

1
Optical signals measurement of discharge plasma in air switch cabinet using a fluorescent optical fiber as the sensor DOI
Hongtu Cheng, Weidong Hao, Xi Zhu

et al.

Physica Scripta, Journal Year: 2024, Volume and Issue: 99(8), P. 085019 - 085019

Published: July 12, 2024

Abstract Air switch cabinets are widely employed in the power industry, there is, however, no reliable methods for detecting partial discharges (PDs). Because fiber optic-based sensors easy to install and have anti-electromagnetic interference capabilities, they well suited PDs detection with their many components metal shell structure. In this work, corona discharge an air cabinet was detected using fluorescent fiber, characteristics of were analyzed. Furthermore, experimental investigations conducted explore impact gas pressure length on detection. The results exhibit a correlation between aforementioned factors PDs’ total amplitude, maximum number pulses limit PD quantity. can provide references application optical cabinet.

Language: Английский

Citations

1
Data-Driven Discovery of a New Fluorescent BASHY Dye for Bioimaging DOI Creative Commons
João M. J. M. Ravasco,

João Felicidade,

Maria V. Pinto

et al.

JACS Au, Journal Year: 2024, Volume and Issue: 4(11), P. 4212 - 4222

Published: Nov. 7, 2024

Fluorescent molecules play a crucial role in biomedicine by facilitating the visualization and tracking of biological processes with sensitivity specificity. However, tailoring their structure to meet demands live cell

Language: Английский

Citations

0