Chemically engineered exogenous organic reactions in living cells for in situ fluorescence imaging and biomedical applications DOI
Gang Song, Zhiwen Yang, Yiming Huang

et al.

Journal of Materials Chemistry B, Journal Year: 2024, Volume and Issue: unknown

Published: Jan. 1, 2024

Key intracellular in situ synthesis processes, including the of near-infrared fluorescent dyes, oxidative cross-linking, polymerization, and bioorthogonal reactions, as well their biomedical applications were summarized.

Language: Английский

Advances in the Delivery, Activation and Therapeutics Applications of Bioorthogonal Prodrugs DOI Open Access
Zhou Zhou, Yuanjun Sun, Jing Pang

et al.

Medicinal Research Reviews, Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 18, 2024

Traditional prodrug strategies have been leveraged to overcome many inherent drawbacks of active native drugs in the drug research and development. However, endogenous stimuli such as specific microenvironment or enzymes are relied on achieve activation, resulting unintended release systemic toxicity. Alternatively, bioorthogonal cleavage reaction-enabled prodrugs activation via exogenous triggers has emerged a valuable approach, featuring spatiotemporally controlled release. Such would ensure targeted delivery and/or situ generation, further circumventing toxicity premature elimination drugs. In recent years, metal-free reactions with fast kinetics boomed design. Meanwhile, transition-metal-catalyzed photocatalytic deprotection also developed trigger biological systems. Besides traditional small molecule prodrugs, gasotransmitters successfully delivered organelles cells reactions, nanosystems devised into well. Herein, we present an overview latest advances these bioorthogonally-uncaged focused delivery, therapeutics applications.

Language: Английский

Citations

1
Bioorthogonal Chemistry-Based Prodrug Strategies for Enhanced Biosafety in Tumor Treatments: Current Progress and Challenges DOI
Yongchao Yao, Ying Chen, Chang Chun Zhou

et al.

Journal of Materials Chemistry B, Journal Year: 2024, Volume and Issue: 12(42), P. 10818 - 10834

Published: Jan. 1, 2024

Prodrugs, activated at the tumor site, offer targeted treatment but may still cause unintended cytotoxicity. This review explores combination of bioorthogonal reactions with prodrug strategies to improve safety and efficacy.

Language: Английский

Citations

0
Imidazole-stabilized gold nanoclusters as photocatalytic initiator and crosslinker to fabricate functional hydrogel DOI
Ning Yang, Fang Gong, Hean Zhang

et al.

Colloids and Surfaces A Physicochemical and Engineering Aspects, Journal Year: 2024, Volume and Issue: unknown, P. 135408 - 135408

Published: Sept. 1, 2024

Language: Английский

Citations

0
Multifunctional biomimetic nanosystem for retinoblastoma treatment DOI

Zide Chen,

Dongyang Wei, Qi Wang

et al.

Chemical Engineering Journal, Journal Year: 2024, Volume and Issue: 499, P. 156017 - 156017

Published: Oct. 5, 2024

Language: Английский

Citations

0
Chemically engineered exogenous organic reactions in living cells for in situ fluorescence imaging and biomedical applications DOI
Gang Song, Zhiwen Yang, Yiming Huang

et al.

Journal of Materials Chemistry B, Journal Year: 2024, Volume and Issue: unknown

Published: Jan. 1, 2024

Key intracellular in situ synthesis processes, including the of near-infrared fluorescent dyes, oxidative cross-linking, polymerization, and bioorthogonal reactions, as well their biomedical applications were summarized.

Language: Английский

Citations

0