Conjugated Polymer for NIR-II Phototheranostics toward Tumor DOI
Jing Wen Pan, Wanlu Li,

Mengyao Wang

et al.

Chemistry of Materials, Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 9, 2024

Due to the strong light trapping ability, good biocompatibility, and easily regulated molecular structure, conjugated polymers are becoming a promising tool for phototheranostics of tumors, which can achieve both precise diagnosis efficient therapeutics. Of particular interest is polymer-based theranostic agents applying second near-infrared (NIR-II) window (1000–1700 nm), exhibit great potential clinical applications on account extremely long wavelength. Herein, basic mechanism, advances in recent 6 years, perspectives polymer NIR-II toward tumor discussed successively. First, mechanisms most widely employed modalities presented. In view heat generation property under photoexcitation, fluorescence imaging (FLI)-guided photothermal therapy (PTT) photoacoustic (PAI)-guided PTT. Then, related FLI-guided PTT technology, PAI-guided multimodel theranostics introduced. Finally, development illustrated practical application simultaneously situ tumor.

Language: Английский

NIR-II aggregation-induced emission nanoparticles camouflaged with preactivated macrophage membranes for phototheranostics of pulmonary tuberculosis DOI
Dingyuan Yan, Xue Li, Huanhuan Wang

et al.

Nature Protocols, Journal Year: 2025, Volume and Issue: unknown

Published: April 10, 2025

Language: Английский

Citations

0
Indacenodithienothiophene-based A-D-A-type phototheranostics for immuno-phototherapy DOI Creative Commons

Yangtian Ye,

Shaojing Zhao,

E Pang

et al.

Journal of Nanobiotechnology, Journal Year: 2025, Volume and Issue: 23(1)

Published: April 23, 2025

Language: Английский

Citations

0
Nanodomain-Enhanced Stable and Multifunctional Probes with Near 100% Quantum Yield for Versatile Biosensing DOI
Zihan Zhang,

Niu Feng,

Xiaobo Hu

et al.

Nano Letters, Journal Year: 2024, Volume and Issue: 24(45), P. 14427 - 14436

Published: Oct. 31, 2024

The preparation of high quantum yield, stable, and multifunctional fluorescent probes is great significance in the fields biomedicine photoelectric sensing. Here, a triphenylamine-based D−π–A molecule (TPA-CN) was designed prepared, demonstrating fluorescence yield 88.84%. With polystyrene nanosphere as carrier, TPA-CN encapsulated inside to form intra-nanosphere confining domains. These nanodomain-enhanced nanospheres exhibited 98.21%. Using antigen–antibody specificity selective catalytic activity bioenzyme, with chloramphenicol model target, dual-signal readout biosensor (in colorimetric modes) for ultrasensitive instrument-free determination. detection limit 24 pg/mL within 30 min mode, 38-fold more sensitive 10-fold faster than that enzyme linked immunosorbent assays. dynamic provide robust versatile solution public health environmental monitoring needs.

Language: Английский

Citations

3
Multi-dimensional donor engineering of NIR-II AIEgens for multimodal phototheranostics of orthotopic breast cancer DOI
Yuan Tao, Jie Cui, Jun Zhu

et al.

Biomaterials, Journal Year: 2025, Volume and Issue: 319, P. 123193 - 123193

Published: Feb. 19, 2025

Language: Английский

Citations

0
Alleviating NIR-II emission quenching in ring-fused fluorophore via manipulating dimer populations for superior fluorescence imaging DOI Creative Commons

Xiaofei Miao,

Mingxuan Jia,

Xiaole Weng

et al.

Light Science & Applications, Journal Year: 2025, Volume and Issue: 14(1)

Published: March 4, 2025

Emission quenching resulting from fluorophore aggregation has long been a significant challenge in optimizing emission-based technologies, such as fluorescence imaging and optoelectronic devices. Alleviating this aggregates is crucial, yet progress impeded by the limited understanding of nature impact on emission. Here, we elucidate critical role dimeric aggregate (dimer) alleviating second near-infrared (NIR-II, 900-1700 nm) emission ring-fused 4F for superior imaging. Spectral decomposition molecular dynamics simulations demonstrate predominance dimer populations aggregates. Notably, dimers exhibit significantly weaker but intense intermolecular nonradiative (interNR) decay compared to monomers, demonstrated ultrafast spectra quantum calculation. Therefore, predominant population with weak pronounced interNR feature underlies This discovery guides preparation ultrabright NIR-II nanofluorophore (4F NP3s) decreasing populations, which show 5-fold greater brightness than indocyanine green, enabling resolution visualizing blood vessels. work offers valuable insights into aggregation-caused quenching, broad implications extending far beyond

Language: Английский

Citations

0
Photoactivated Self‐Assembled Nanomicelles Integrating Mitophagy Inhibition to Enhance Pyroptosis for Cancer Immunotherapy DOI Open Access

K. Dong,

Yang Xu, Yuqi Tang

et al.

Advanced Functional Materials, Journal Year: 2025, Volume and Issue: unknown

Published: March 26, 2025

Abstract Multimodal therapy often demonstrates superior therapeutic effects compared to monotherapy. Phototherapy is a promising approach for cancer treatment, as it can induce tumor pyroptosis and activate antitumor immune responses. However, mitochondrial oxidative stress during frequently stimulates protective autophagy in cells, thereby seriously impeding the progress of pyroptosis. Therefore, developing that enhances through inhibiting critical improving treatment efficacy. In this study, photoactivated mitochondrial‐targeting self‐assembled nanomicelle ( 3M@C ) integrates an aggregation‐induced emission photosensitizer inhibitor chloroquine designed. generate both type I II reactive oxygen species heat under light exposure, inducing dysfunction triggering pyroptosis, achieving photodynamic synergistic photothermal therapy. Meanwhile, inhibit mitophagy, further enhance effects, vivo experiments demonstrate strategy exhibits excellent biosafety significant efficacy, effectively suppressing growth. addition, method nanomicelles mitophagy inhibition providing novel photoimmunotherapy.

Language: Английский

Citations

0
Visible‐Light‐Driven Multifunctional Luminogens With More Than 150 Nm Absorption Band Separation for Dynamic Information Encryption DOI Creative Commons
Shijie Zhen,

Feng Ma,

Hong Chen

et al.

Aggregate, Journal Year: 2025, Volume and Issue: unknown

Published: April 16, 2025

ABSTRACT Information security protection has become a fundamental issue in the human life, national security, and social stability, which is enabled through use of multi‐responsive materials. Ideal materials are operated with visible to near infrared light, exhibit large separation absorption bands, functional by isomerization, posing an unmet challenge. Here, series visible‐light‐operated molecular photoswitches, ( E )‐1‐acetyl‐2‐((4‐(diphenylamino) phenyl) imino) indolin‐3‐one, its derivatives PIO‐01/02/03/04/05 ), featuring near‐infrared second aggregation‐induced emission (AIE) impressive acid/base‐driven switching, constructed via twisted intramolecular charge transfer (TICT) subsequent / Z isomerization strategies. In addition, protonation not only endows these molecules (Δ λ max ) over 100 nm, but also can be used as independent input altering light response. Based on calculation studies advanced spectroscopic techniques, we provide intricate interplay switching behavior their photochemical properties. The optimized compound PIO‐01 shows significant applications multi‐color, multi‐patterning display, transient information recording erasing, dual‐mode encryption‐decryption ternary code.

Language: Английский

Citations

0
Research Progress in the Treatment of High-Grade Glioma in Recent Years DOI

禹伯 董

Advances in Clinical Medicine, Journal Year: 2025, Volume and Issue: 15(04), P. 2936 - 2946

Published: Jan. 1, 2025

Language: Английский

Citations

0
Precise Molecular Engineering of Multi‐Suborganelle Targeted NIR Type‑I AIE Photosensitizer and Design of Cell Membrane‐Anchored Anti‐Tumor Pyroptosis Vaccine DOI Open Access
Chunbai Xiang, Yu Liu, Qihang Ding

et al.

Advanced Functional Materials, Journal Year: 2024, Volume and Issue: unknown

Published: Nov. 22, 2024

Abstract Photodynamically induced cell immunogenic death has emerged as an effective antitumor strategy because of its capacity to stimulate anti‐tumor immunity for eliminating primary tumors and metastases. Considering that the short‐lived reactive oxygen species (ROS) anoxic tumor microenvironment restrict efficacy conventional photodynamic therapy (PDT), a molecular framework near‐infrared (NIR) type I aggregation‐induced emission (AIE) photosensitivities with tunable sub‐organelles (including membranes, mitochondria, lipid drops, lysosomes, endoplasmic reticulum) targeting ROS in precisely regulated subcellular locations are designed. Subsequent studies have discovered under 660 nm laser irradiation, membrane‐targeted TCF‐Mem can effectively induce pyroptosis cancer cells, fully enhancing vivo preventive vaccine model. Additionally, PDT eradicate and, more importantly, inhibit growth distant through vitro actions, thereby obtaining specific immunity. This study provides novel rational design photosensitive NIR AIE offers new perspective innovative PDT‐based immune enhancement strategies.

Language: Английский

Citations

3
Engineering a Near-Infrared Spiro-Based Aggregation-Induced Emission Luminogen for DNAzyme-Sensitized Photothermal Therapy with High Efficiency and Accuracy DOI
Yingying Chen, Shengyi Yang, Xinwen Ou

et al.

Journal of the American Chemical Society, Journal Year: 2024, Volume and Issue: 146(51), P. 35462 - 35477

Published: Dec. 12, 2024

Aggregation-induced emission luminogen (AIEgens)-based photothermal therapy (PTT) has grown into a sparkling frontier for tumor ablation. However, challenges remain due to the uncoordinated photoluminescence (PL) and properties of classical AIEgens, along with hyperthermia-induced antiapoptotic responses in cells, hindering satisfactory therapeutic outcomes. Herein, near-infrared (NIR) spiro-AIEgen TTQ-SA was designed boosted PTT by auxiliary DNAzyme-regulated cell sensitization. unique molecular structure packing mode initially fabricated, endowing it strong AIE effect, favorable PL quantum yield, good performance. DNAzyme, as gene silencing tool, could alleviate antiapoptosis response during PTT. By integrating DNAzyme folate-modified poly(lactic-co-glycolic acid) (PLGA) polymer, as-fabricated nanosystem promote apoptosis sensitize cells PTT, thereby maximizing With combination spiro-AIEgen-based DNAzyme-based silencing, as-designed showed promising NIR imaging abilities targeting demonstrated significant apoptotic, antitumor, antimetastasis effects against orthotopic breast cancer. Furthermore, synergistic antitumor effect realized spontaneous MMTV-PyMT transgenic mice. These findings offer new insights AIEgen-based theranostics sensitization, paving way silencing-PTT nanoplatforms clinical research.

Language: Английский

Citations

3