ChemMedChem,
Journal Year:
2024,
Volume and Issue:
unknown
Published: Oct. 8, 2024
Abstract
With
the
rapid
advancement
of
DNA
technology,
intelligent
nanoreactors
(iDNRs)
have
emerged
as
sophisticated
tools
that
harness
structural
versatility
and
programmability
DNA.
Due
to
their
functional
programmability,
iDNRs
play
an
important
unique
role
in
vivo
tumor
diagnosis
therapy.
This
review
provides
overview
design
methods
for
based
on
advanced
including
enzymatic
reaction‐mediated
enzyme‐free
strategies.
also
focuses
how
achieve
intelligence
through
design,
well
applications
In
summary,
this
summarizes
current
advances
discusses
existing
challenges,
proposes
future
directions
expanding
applications,
which
are
expected
provide
insights
into
development
field
diagnostics
targeted
therapies.
Chem & Bio Engineering,
Journal Year:
2025,
Volume and Issue:
2(3), P. 171 - 181
Published: Jan. 31, 2025
Advancements
in
cell
separation
are
essential
for
understanding
cellular
phenotypes
and
functions,
with
implications
both
research
therapeutic
applications.
This
review
examines
the
evolution
of
techniques,
categorizing
them
into
physical
affinity-based
methods,
a
primary
focus
on
latter
due
to
its
high
specificity.
Among
affinity
DNA
nanomaterials
have
emerged
as
powerful
tools
biomolecular
recognition
owing
their
unique
properties
diverse
range
nanostructures.
We
discuss
various
nanomaterials,
including
linear
aptamers,
multivalent
constructs,
origami,
hydrogels
roles
separation.
Each
section
highlights
distinctive
characteristics
these
nanostructures,
providing
examples
from
recent
studies
that
demonstrate
applications
isolation
release.
also
compare
four
outlining
individual
contributions
identifying
remaining
challenges
opportunities
further
development.
conclude
nanotechnology
holds
great
promise
transformative
solution
separation,
particularly
context
personalized
therapeutics.
JACS Au,
Journal Year:
2025,
Volume and Issue:
5(2), P. 550 - 570
Published: Feb. 6, 2025
Cell
surface
engineering
is
a
rapidly
advancing
field,
pivotal
for
understanding
cellular
physiology
and
driving
innovations
in
biomedical
applications.
In
this
regard,
DNA
nanotechnology
offers
unprecedented
potential
precisely
manipulating
functionalizing
cell
surfaces
by
virtue
of
its
inherent
programmability
versatile
functionalities.
Herein,
Perspective
provides
comprehensive
overview
emerging
trends
engineering,
focusing
on
key
nanostructure-based
tools,
their
roles
regulating
physiological
processes,
We
first
discuss
the
strategies
integrating
molecules
onto
surfaces,
including
attachment
oligonucleotides
higher-order
nanostructure.
Second,
we
summarize
impact
DNA-based
various
such
as
membrane
protein
degradation,
signaling
transduction,
intercellular
communication,
construction
artificial
components.
Third,
highlight
applications
DNA-engineered
targeted
therapies
cancer
inflammation,
well
capture/protection
diagnostic
detection.
Finally,
address
challenges
future
directions
nanotechnology-based
engineering.
This
aims
to
provide
valuable
insights
rational
design
contributing
development
precise
personalized
medicine.
Small Methods,
Journal Year:
2025,
Volume and Issue:
unknown
Published: Jan. 22, 2025
Abstract
Current
tumor
vaccines
suffer
from
inadequate
immune
responsive
due
to
the
insufficient
release
of
antigens,
low
infiltration,
and
immunosuppressive
microenvironment.
DNA
nanostructures
with
their
ability
precisely
engineer,
controlled
release,
biocompatibility,
capability
augment
immunogenicity
microenvironment,
have
gained
significant
attention
for
potential
revolutionize
vaccine
designing.
This
review
summarizes
various
applications
in
construction
situ
cancer
vaccines,
which
can
generate
tumor‐associated
antigens
directly
damaged
tumors
immune‐stimulation.
The
mechanisms
components
are
listed,
specific
strategies
constructing
using
explored
underlying
action
elucidated.
immunogenic
cell
death
(ICD)
induced
by
chemotherapeutic
agents,
photothermal
therapy
(PTT),
photodynamic
(PDT),
radiation
(RT)
related
building
systematically
summarized.
different
immunotherapy
elaborated,
exerts
precise,
long‐lasting,
robust
responses.
current
challenges
future
prospectives
proposed.
provides
a
holistic
understanding
evolving
role
development.
Chemical Communications,
Journal Year:
2025,
Volume and Issue:
unknown
Published: Jan. 1, 2025
This
review
discusses
design
strategies
for
external
stimuli-driven
hydrogels
with
in
situ
catalytic
processes.
It
highlights
precise
control
over
the
properties,
elucidating
regulatory
mechanisms
and
deepening
understanding
of
applications.
Advanced Healthcare Materials,
Journal Year:
2025,
Volume and Issue:
unknown
Published: April 10, 2025
Abstract
DNA
hydrogels
have
emerged
as
promising
materials
in
tissue
engineering
due
to
their
biocompatibility,
programmability,
and
responsiveness
stimuli.
Synthesized
through
physical
chemical
crosslinking,
these
can
be
categorized
into
functionalized
types,
such
those
based
on
aptamers,
stimuli‐responsive
types
that
react
pH,
temperature,
light.
This
review
highlights
applications
engineering,
including
drug
delivery,
cell
culture,
biosensing,
gene
editing.
encapsulate
therapeutic
agents,
support
growth,
respond
dynamically
environmental
changes,
making
them
ideal
for
engineering.
A
comprehensive
bibliometric
analysis
is
included,
identifying
key
research
trends
emerging
areas
of
interest
hydrogel
design,
synthesis,
biomedical
applications.
The
provides
a
deeper
understanding
the
field's
development
future
directions.
Challenges
mechanical
strength,
stability,
biosafety
persist,
but
integration
AI
design
shows
promise
advancing
functionality
clinical
Biomaterials Science,
Journal Year:
2024,
Volume and Issue:
unknown
Published: Jan. 1, 2024
The
development
of
new
multi-responsive
injectable
hydrogels
with
cascades
or
even
synergistic
effects
will
be
great
significance
in
the
field
precision
medicine.
Analytical Chemistry,
Journal Year:
2025,
Volume and Issue:
unknown
Published: April 4, 2025
Circulating
tumor
cells
(CTCs)
have
emerged
as
critical
biomarkers
in
liquid
biopsy
for
noninvasive
diagnosis
and
real-time
monitoring
of
cancer
progression.
However,
the
isolation
CTCs
is
often
required
before
detection
due
to
their
ultralow
abundance
peripheral
blood.
These
processes
are
typically
time-consuming
prone
cell
loss,
which
limits
utility
CTC-based
biopsy.
Herein,
we
present
a
DNA
network-based
diagnostic
system
that
enables
specific
recognition,
selective
enrichment,
accurate
directly
from
blood
samples.
The
network
comprises
ultralong
chains
embedded
with
polyvalent
aptamers
fluorescence
modules.
selectively
bind
epithelial
adhesion
molecule
(EpCAM)
on
CTC
membrane,
facilitating
enrichment
through
base
pairing-driven
formation.
This
semiquantitatively
detects
expression
level
cancer-associated
microRNA
within
using
ratiometric
imaging
based
chemical
assembly
two
In
clinical
samples,
this
achieves
100%
precision
96%
accuracy
distinguishing
breast
patients
healthy
donors,
highlighting
its
promising
potential
diagnosis.
