Unconventional Parahydrogen-Induced Hyperpolarization Effects in Chemistry and Catalysis: From Photoreactions to Enzymes DOI Creative Commons
Andrey N. Pravdivtsev, Ben. J. Tickner, Stefan Glöggler

et al.

ACS Catalysis, Journal Year: 2025, Volume and Issue: unknown, P. 6386 - 6409

Published: April 4, 2025

Nuclear spin hyperpolarization utilizing parahydrogen has the potential for broad applications in chemistry, catalysis, biochemistry, and medicine. This review examines recent chemical biochemical insights gained using parahydrogen-induced polarization (PHIP). We begin with photoinduced PHIP, which allows investigation of short-lived photoactivated catalysis. Next, we partially negative line effect, distinctive shape helps to reveal information about rapid exchange role catalytic species. The NMR signal enhancement a single proton oneH-PHIP is discussed, challenging underpinning concept necessity pairwise hydrogenation. Furthermore, examine metal-free PHIP facilitated by frustrated Lewis pair molecular tweezers radicaloids, demonstrating alternative routes Although symmetric molecules incorporating are silent, showcase methods that hyperpolarized states through post-hydrogenation reactions. discuss processes mediate transfer between target, expanding reach without synthesizing specialized precursors. conclude this highlighting uncovering H2 activation mechanisms hydrogenases. By providing detailed these diverse phenomena, aim familiarize reader versatility its mechanistic studies analysis.

Language: Английский

Unconventional Parahydrogen-Induced Hyperpolarization Effects in Chemistry and Catalysis: From Photoreactions to Enzymes DOI Creative Commons
Andrey N. Pravdivtsev, Ben. J. Tickner, Stefan Glöggler

et al.

ACS Catalysis, Journal Year: 2025, Volume and Issue: unknown, P. 6386 - 6409

Published: April 4, 2025

Nuclear spin hyperpolarization utilizing parahydrogen has the potential for broad applications in chemistry, catalysis, biochemistry, and medicine. This review examines recent chemical biochemical insights gained using parahydrogen-induced polarization (PHIP). We begin with photoinduced PHIP, which allows investigation of short-lived photoactivated catalysis. Next, we partially negative line effect, distinctive shape helps to reveal information about rapid exchange role catalytic species. The NMR signal enhancement a single proton oneH-PHIP is discussed, challenging underpinning concept necessity pairwise hydrogenation. Furthermore, examine metal-free PHIP facilitated by frustrated Lewis pair molecular tweezers radicaloids, demonstrating alternative routes Although symmetric molecules incorporating are silent, showcase methods that hyperpolarized states through post-hydrogenation reactions. discuss processes mediate transfer between target, expanding reach without synthesizing specialized precursors. conclude this highlighting uncovering H2 activation mechanisms hydrogenases. By providing detailed these diverse phenomena, aim familiarize reader versatility its mechanistic studies analysis.

Language: Английский

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