Damaged
skin
compromises
its
ability
to
effectively
prevent
the
invasion
of
harmful
bacteria
into
tissue,
leading
bacterial
infection
wound
and
hindering
healing
process.
To
address
this
challenge,
we
have
developed
a
multifunctional
asymmetric
dressing
(CuPt-Cur-ABC)
that
addresses
lack
bactericidal
activity
release
active
ingredients
in
conventional
cellulose
(BC),
which
can
be
employed
create
barrier
defense
between
surrounding
environment.
Compared
with
BC,
(ABC)
used
starch
as
pore-causing
agent,
forming
holes
different
sizes
at
top
bottom,
enhanced
ABC
load
moderate-release
drugs.
First,
as-synthesized
CuPt
nanozymes
an
octopod
nanoframe
structure
had
multiple
enzymatic
activities
including
peroxidase-like,
catalase-like,
glutathione
peroxidase-like
activities.
Then,
curcumin
(Cur)
were
loaded
under
ultrasound.
Under
808
nm
laser
irradiation,
nanocomposites
possessed
good
photothermal
properties.
So
therapy
combined
chemodynamic
inherent
antibacterial
performance
Cur
achieved
99.3%
99.6%
Advanced Functional Materials,
Journal Year:
2024,
Volume and Issue:
unknown
Published: Aug. 6, 2024
Abstract
Recent
research
on
ferroptosis
and
cuproptosis
has
underscored
the
crucial
role
of
trace
element
regulation
in
osteoarthritis
(OA)
treatment.
However,
systematically
addressing
alterations
nutrient
elements
OA
cartilage
is
lacking.
This
study
initiated
using
clinical
specimens
to
quantify
metal
concentrations
both
damaged
intact
identify
deficient
within
inflammatory
senescent
microenvironments
OA.
Based
preliminary
findings
selenium
(Se)
gallium
(Ga)
deficiencies
cartilage,
tailored
nanoparticles
based
Se
Ga
are
designed
validated
for
their
antioxidant
ability.
GaSe
x
demonstrated
significant
efficacy
mitigating
chondrocyte
degeneration
extracellular
matrix
degradation
induced
by
factors
alleviating
abrasion,
hyperalgesia,
abnormal
gait
a
destabilization
medial
meniscus
(DMM)
mouse
model.
Mechanistically,
activated
Nrf2
pathway
competitively
inhibited
ubiquitin‐mediated
Gpx4,
thus
inhibiting
ferroptosis.
imbalance
knee
joint
microenvironment
robust
capabilities
remarkable
competitive
properties
ubiquitin,
thereby
providing
novel
therapeutic
solution
Aggregate,
Journal Year:
2024,
Volume and Issue:
unknown
Published: Sept. 28, 2024
Abstract
Persistent
biofilm
infections
pose
a
critical
health
threat
with
their
relentless
presence
and
amplified
antibiotic
resistance.
Traditional
antibacterial
photodynamic
therapy
can
inhibit
bacteria
extracellularly
but
struggles
to
control
formation
virulence.
Thus,
there
is
an
urgent
need
develop
photosensitizers,
such
as
ultra‐small
gold
nanoclusters
(AuNCs),
that
penetrate
biofilms
internalize
into
bacteria.
However,
AuNCs
still
face
the
challenge
of
insufficient
reactive
oxygen
species
(ROS)
production
limited
near‐infrared
light
absorption.
This
study
develops
model
indocyanine
green
(ICG)‐sensitized
atomic‐precision
size
effect.
approach
achieved
absorption
while
inhibiting
radiation
transitions,
thereby
regulating
generation
ROS.
Notably,
different‐sized
(Au
10
NCs,
Au
15
25
NCs)
yielded
varied
ROS
types,
resulting
from
different
energy
level
distributions
electron
transfer
rates.
ICG‐Au
NCs
treatment
efficacy
99.94%
against
Staphylococcus
aureus
in
vitro
significantly
accelerated
wound
healing
vivo.
Moreover,
this
highlights
unique
role
ICG‐AuNCs
suppressing
quorum
sensing,
virulence,
ABC
transporters
compared
larger
counterparts.
strategy
demonstrates
effect
paves
way
for
innovative
approaches
infection
control.
Nano Letters,
Journal Year:
2024,
Volume and Issue:
unknown
Published: Dec. 9, 2024
Strategic
integration
of
adhesive
hydrogels
with
phototherapy-based
antibacterial
properties
has
been
extensively
leveraged
in
infected
tissue
repair.
Nevertheless,
the
interference
bacterial
heat
shock
proteins
and
antioxidant
defense
systems
attenuates
bactericidal
potency
phototherapy.
To
address
this
imposing
predicament,
a
Trojan
horse
bioheterojunction
(Th-bioHJ)
incorporating
liquid
metal
copper
sulfide
is
devised
to
confer
an
hydrogel
multimodal
comprehensive
for
remedying
infectious
wounds.
Th-bioHJ
generates
phototherapeutic
effects
interrupts
electron
transport
chain
strategy,
achieving
rapid
robust
sterilization.
Additionally,
promotes
cell
migration
angiogenesis.
Damaged
skin
compromises
its
ability
to
effectively
prevent
the
invasion
of
harmful
bacteria
into
tissue,
leading
bacterial
infection
wound
and
hindering
healing
process.
To
address
this
challenge,
we
have
developed
a
multifunctional
asymmetric
dressing
(CuPt-Cur-ABC)
that
addresses
lack
bactericidal
activity
release
active
ingredients
in
conventional
cellulose
(BC),
which
can
be
employed
create
barrier
defense
between
surrounding
environment.
Compared
with
BC,
(ABC)
used
starch
as
pore-causing
agent,
forming
holes
different
sizes
at
top
bottom,
enhanced
ABC
load
moderate-release
drugs.
First,
as-synthesized
CuPt
nanozymes
an
octopod
nanoframe
structure
had
multiple
enzymatic
activities
including
peroxidase-like,
catalase-like,
glutathione
peroxidase-like
activities.
Then,
curcumin
(Cur)
were
loaded
under
ultrasound.
Under
808
nm
laser
irradiation,
nanocomposites
possessed
good
photothermal
properties.
So
therapy
combined
chemodynamic
inherent
antibacterial
performance
Cur
achieved
99.3%
99.6%
