Computational Exploration of the Mechanism of Action of a Sorafenib-Containing Ruthenium Complex as an Anticancer Agent for Photoactivated Chemotherapy
Molecules,
Journal Year:
2024,
Volume and Issue:
29(18), P. 4298 - 4298
Published: Sept. 11, 2024
Ruthenium(II)
polypyridyl
complexes
are
being
tested
as
potential
anticancer
agents
in
different
therapies,
which
include
conventional
chemotherapy
and
light-activated
approaches.
A
mechanistic
study
on
a
recently
synthesized
dual-action
Ru(II)
complex
[Ru(bpy)
Language: Английский
Self-assembly nanomedicine initiating cancer-immunity cycle with cascade reactions for boosted immunotherapy
Yajing Guo,
No information about this author
Bingyuan Liu,
No information about this author
Lixin Yin
No information about this author
et al.
Chemical Engineering Journal,
Journal Year:
2024,
Volume and Issue:
503, P. 158143 - 158143
Published: Nov. 30, 2024
Language: Английский
铱(III)光敏剂的设计与抗肿瘤研究进展
Qiaoshan Lie,
No information about this author
Hui Chao
No information about this author
Scientia Sinica Chimica,
Journal Year:
2024,
Volume and Issue:
54(9), P. 1522 - 1533
Published: June 20, 2024
光动力疗法(PDT)利用光激活光敏剂(PSs)产生治疗肿瘤的有毒物质,因其特定的时空选择性、无创性以及不易产生耐药性等优点,现已成为癌症治疗的新兴解决方案。近年来,铱(III)配合物因其优异的光物理、光化学和光生物学特性而作为光敏剂引起了广泛关注。本文对铱(III)配合物在光动力治疗肿瘤方面的研究进展进行综述,主要介绍了应用于单/双光子光动力治疗以及基于纳米复合体系设计的铱(III)光敏剂,为开发新型金属抗肿瘤药物提供参考。另外,还总结了近年来铱(III)配合物在光动力免疫抗肿瘤方面的研究,为发展精准高效治疗肿瘤提供一种新的策略。最后,对铱(III)光敏剂在抗癌应用上的前景进行了展望。