Lactate/Cysteine Dual-Consuming Probiotic–Nanomedicine Biohybrid System for Enhanced Cancer Chemo-Immunotherapy

Nano Letters, Journal Year: 2024, Volume and Issue: 24(50), P. 16132 - 16142

Published: Dec. 6, 2024

Immunotherapy is revolutionizing oncology, but its therapeutic efficiency still limited by the off-target toxicities and poor antitumor immune responses. By integrating drug-loaded nanoparticles (DMnSH) with unique metabolic traits of Veillonella parvula (Vei), a probiotic–nanomedicine conjugate Vei@DMnSH biohybrid elaborately designed for enhanced cancer chemo-immunotherapy. Specifically, can accumulate in hypoxic tumor sites simultaneously consume lactate cysteine to reverse lactate-associated immunosuppression impede biosynthesis GSH. In addition, DMnSH will rapidly deplete intracellular GSH disassemble release DOX Mn2+. Accompanied two-pronged depletion, Mn2+-mediated Fenton-like reaction effectively generate oxidative hydroxyl radicals induce heavy redox imbalance. Combined effect DOX, robust immunogenic cell death provoked subsequently activates adaptive immunity suppression rate over 82%, synergistically enhancing outcomes

Language: Английский

The human gut Bacteroides eggerthii expresses a new galactofuranose-containing lipooligosaccharide with weak immunostimulatory properties

Carbohydrate Polymers, Journal Year: 2024, Volume and Issue: 348, P. 122833 - 122833

Published: Oct. 5, 2024

Language: Английский