Modulating Pore Wall Chemistry Empowers Sonodynamic Activity of Two‐Dimensional Covalent Organic Framework Heterojunctions for Pro‐Oxidative Nanotherapy DOI Open Access

Ruohui Wu,

Mengying Hua,

Yanjia Lu

et al.

Angewandte Chemie, Journal Year: 2024, Volume and Issue: unknown

Published: Oct. 10, 2024

Abstract Covalent organic frameworks (COFs) have garnered growing interest in the field of biomedicine; however, their application sonodynamic therapy remains underexplored due to limited understanding intrinsic activity and structure–property relationships. Here, we present a pore wall chemistry modulation strategy for empowering two‐dimensional (2D) COF heterojunctions through situ growth COFs on bismuth oxycarbonate nanosheets (B NSs). Compared negligible effects observed pristine B NSs, 2D heterojunction with vinyl‐decorated walls demonstrates 3.6‐fold enhancement sonocatalytic singlet oxygen generation. This performance also significantly outperforms that isoreticular functionalized methoxy or non‐substituted groups. Mechanistic studies reveal vinyl groups B@COF (BC) facilitate separation transfer charge carriers while enhancing adsorption molecules. Furthermore, peroxymonosulfate (PMS) loading into porous boosts therapeutic efficacy antitumor nanotherapy via dual oxidative species These findings underscore critical role modulating properties COFs, advance development COF‐based sonosensitizers pro‐oxidative applications.

Language: Английский

Modulating Pore Wall Chemistry Empowers Sonodynamic Activity of Two‐Dimensional Covalent Organic Framework Heterojunctions for Pro‐Oxidative Nanotherapy DOI Open Access

Ruohui Wu,

Mengying Hua,

Yanjia Lu

et al.

Angewandte Chemie, Journal Year: 2024, Volume and Issue: unknown

Published: Oct. 10, 2024

Abstract Covalent organic frameworks (COFs) have garnered growing interest in the field of biomedicine; however, their application sonodynamic therapy remains underexplored due to limited understanding intrinsic activity and structure–property relationships. Here, we present a pore wall chemistry modulation strategy for empowering two‐dimensional (2D) COF heterojunctions through situ growth COFs on bismuth oxycarbonate nanosheets (B NSs). Compared negligible effects observed pristine B NSs, 2D heterojunction with vinyl‐decorated walls demonstrates 3.6‐fold enhancement sonocatalytic singlet oxygen generation. This performance also significantly outperforms that isoreticular functionalized methoxy or non‐substituted groups. Mechanistic studies reveal vinyl groups B@COF (BC) facilitate separation transfer charge carriers while enhancing adsorption molecules. Furthermore, peroxymonosulfate (PMS) loading into porous boosts therapeutic efficacy antitumor nanotherapy via dual oxidative species These findings underscore critical role modulating properties COFs, advance development COF‐based sonosensitizers pro‐oxidative applications.

Language: Английский

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