Design of Soluble Compounds for Optical Control of Tetrameric P-Loop Ion Channels DOI Creative Commons

E. D. Gataulina,

Maxim V. Nikolaev, Denis B. Tikhonov

et al.

Journal of Evolutionary Biochemistry and Physiology, Journal Year: 2024, Volume and Issue: 60(6), P. 2241 - 2254

Published: Nov. 1, 2024

Abstract The photopharmacology of ion channels is a rapidly developing area. One reason for paying special attention to the design photoswitchable ligands that control fast neurophysiological processes, and their ability be locally modulated by light very important. In channels, existing drugs are usually employed photochromic analogs through incorporation moiety. At present, compounds designed many belong superfamily so-called P-loop channels. Photoswitchable differ in activities, photosensitivity, selectivity, mechanisms action. This paper provides an overview available structures.

Language: Английский

Brief analysis of Nav1.7 inhibitors: Mechanism of action and new research trends DOI
Zhoujun Dong,

Baichen Xiong,

Tian‐Yu Sun

et al.

Bioorganic & Medicinal Chemistry, Journal Year: 2025, Volume and Issue: unknown, P. 118180 - 118180

Published: April 1, 2025

Language: Английский

Citations

0
Recent advances in photopharmacology: Harnessing visible light‐activated azobenzene photoswitches DOI Creative Commons

Yongliang Feng,

Kun Zhang,

Xingrui Gao

et al.

Deleted Journal, Journal Year: 2025, Volume and Issue: unknown

Published: April 25, 2025

Abstract In the era of precision medicine, photopharmacology that employs molecular photoswitches offers unique opportunities to control action bioactive molecules with high spatiotemporal resolution, while reducing drug side effects, systemic toxicity and emergence resistance. Over past two decades, field has witnessed great achievements in treating blindness, cancer, diabetes, antibiotic resistance, name but a few. Several challenges remain, however, particular fact most photopharmacological agents trigger their activity by Ultraviolet light, which is damaging normal cells poor tissue permeability. Visible light‐activated are hence highly desirable have captured keen recent research interest. This review highlights strategies for synthesis visible light‐responsive azobenzenes (ABs) applications emerging photopharmacology. Such photoswitchable drugs tremendously extend scope future vivo applications. Furthermore, we identify current discuss rational design switches at higher wavelength. We hope inspire further into photochemistry novel based on ABs or other photoswitches, triggered excitation light “phototherapeutic window” 650–900 nm, ultimately enabling full realization these “smart” clinical practice.

Language: Английский

Citations

0
Light-Activated Agonist-Potentiator of GABAA Receptors for Reversible Neuroinhibition in Wildtype Mice DOI Creative Commons
Galyna Maleeva, Alba Nin‐Hill,

Ulrike Wirth

et al.

Journal of the American Chemical Society, Journal Year: 2024, Volume and Issue: 146(42), P. 28822 - 28831

Published: Oct. 9, 2024

Gamma aminobutyric acid type A receptors (GABA

Language: Английский

Citations

1
Design of Soluble Compounds for Optical Control of Tetrameric P-Loop Ion Channels DOI Creative Commons

E. D. Gataulina,

Maxim V. Nikolaev, Denis B. Tikhonov

et al.

Journal of Evolutionary Biochemistry and Physiology, Journal Year: 2024, Volume and Issue: 60(6), P. 2241 - 2254

Published: Nov. 1, 2024

Abstract The photopharmacology of ion channels is a rapidly developing area. One reason for paying special attention to the design photoswitchable ligands that control fast neurophysiological processes, and their ability be locally modulated by light very important. In channels, existing drugs are usually employed photochromic analogs through incorporation moiety. At present, compounds designed many belong superfamily so-called P-loop channels. Photoswitchable differ in activities, photosensitivity, selectivity, mechanisms action. This paper provides an overview available structures.

Language: Английский

Citations

0