Metabolic Acidity/H2O2 Dual‐Cascade‐Activatable Molecular Imaging Platform toward Metastatic Breast Tumor Malignancy DOI

Kun Dou,

Jiao Lu, Yanlong Xing

et al.

Angewandte Chemie, Journal Year: 2024, Volume and Issue: unknown

Published: Nov. 8, 2024

Abstract Fluorescence imaging in the second near‐infrared window (NIR‐II) is crucial for accurate tumor diagnosis, offering superior resolution and penetration capabilities. Current NIR‐II probes are limited by either being “always on” or responding to one stimulus, leading low signal‐to‐noise ratios potential false positives. We introduced a dual‐lock‐controlled probe, HN‐PBA , activated both H 2 O acidic environment. This dual response ensures bright fluorescence at sites, higher tumor‐to‐normal tissue (T/NT) compared conventional only . strategy allows precise identification removal of primary metastatic tumors, achieving T/NT (24.3/6.4 orthotopic lung metastasis, respectively). Our probe also effectively detected foci as small as≤0.7 mm showed capability lesion localization clinical breast cancer specimens. dual‐stimuli‐responsive could aid future diagnostic design.

Language: Английский

Metabolic Acidity/H2O2 Dual‐Cascade‐Activatable Molecular Imaging Platform toward Metastatic Breast Tumor Malignancy DOI

Kun Dou,

Jiao Lu, Yanlong Xing

et al.

Angewandte Chemie, Journal Year: 2024, Volume and Issue: unknown

Published: Nov. 8, 2024

Abstract Fluorescence imaging in the second near‐infrared window (NIR‐II) is crucial for accurate tumor diagnosis, offering superior resolution and penetration capabilities. Current NIR‐II probes are limited by either being “always on” or responding to one stimulus, leading low signal‐to‐noise ratios potential false positives. We introduced a dual‐lock‐controlled probe, HN‐PBA , activated both H 2 O acidic environment. This dual response ensures bright fluorescence at sites, higher tumor‐to‐normal tissue (T/NT) compared conventional only . strategy allows precise identification removal of primary metastatic tumors, achieving T/NT (24.3/6.4 orthotopic lung metastasis, respectively). Our probe also effectively detected foci as small as≤0.7 mm showed capability lesion localization clinical breast cancer specimens. dual‐stimuli‐responsive could aid future diagnostic design.

Language: Английский

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