Real-Time 5-Hydroxyindoleacetic Acid Monitoring in Guinea Pig Brain Using a Molecular Imprinted Polymer-Based Galvanic Redox Potentiometric Sensor
Yuxin Peng,
No information about this author
Fenghui Zhu,
No information about this author
Huan Wei
No information about this author
et al.
Analytical Chemistry,
Journal Year:
2025,
Volume and Issue:
unknown
Published: Jan. 27, 2025
5-Hydroxyindoleacetic
acid
(5-HIAA),
a
vital
metabolite
of
serotonin
(5-HT),
is
crucial
for
understanding
metabolic
pathways
and
implicated
in
various
mental
disorders.
In
situ
monitoring
5-HIAA
challenging
due
to
the
lack
affinity
ligands
issues
with
electrochemical
fouling.
We
present
an
advanced
sensing
approach
that
integrates
customizable
molecular
imprinting
polymer
(MIP)
self-driven
galvanic
redox
potentiometry
(GRP)
precise,
real-time
vivo
5-HIAA.
The
sensor,
featuring
pyrrole
as
functional
monomer
MIP
on
micrometer-sized
bipolar
carbon
fiber
electrodes,
exhibited
nanomolar
sensitivity
superior
selectivity
over
biosynthetic
pathway
analogs
like
5-hydroxytryptophan
(5-HTP)
serotonin.
MIPGRP
sensor
demonstrated
excellent
reversibility
resistance
fouling,
enabling
continuous
live
guinea
pig
brains.
observed
intraperitoneal
5-HTP
injection
increases
brain
levels,
which
amplified
up
8-fold
Carbidopa
pretreatment,
providing
deeper
insights
into
serotonergic
signaling
pathway.
This
work
underscores
sensor's
potential
versatile
reliable
tool
advancing
neuroscience
research.
Language: Английский
Tailoring the Electrocatalytic Properties of Porphyrin Covalent Organic Frameworks for Highly Selective Oxygen Sensing In Vivo
Jiawei Lai,
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Yao Tian,
No information about this author
Huan Wei
No information about this author
et al.
Analytical Chemistry,
Journal Year:
2025,
Volume and Issue:
unknown
Published: Feb. 5, 2025
In
vivo
selective
sensing
of
oxygen
(O2)
dynamics
in
the
central
nervous
system
could
provide
insights
into
energy
metabolism
and
neural
activities.
Although
electrocatalytic
four-electron
reduction
reaction
(ORR)
paves
an
effective
way
to
electrochemical
O2
vivo,
concurrent
hydrogen
peroxide
(HPRR)
within
potential
windows
for
ORR
unfortunately
poses
a
great
challenge
conventional
mechanism
employed
sensing.
this
work,
we
find
that
regulation
linkers
skeleton
porphyrin-based
covalent
organic
frameworks
(COFs)
improve
selectivity
sensor
against
(H2O2).
The
results
reveal
Co
porphyrin
active
sites
facilitate
direct
pathway
COF,
enriched
with
pyrene
units,
shows
enhanced
kinetics
better
tolerance
HPRR.
theoretical
calculation
suggests
introducing
units
essentially
weakens
adsorption
H2O2,
leading
suppression
microsensor
fabricated
COF
as
electrocatalyst
features
high
real-time
monitoring
living
rat
brain.
Language: Английский
A systematic investigation into the influencing factors of nanosized catalytic graphitization and their impact on lithium-ion storage performance
Tao Wan,
No information about this author
Weihua Wan,
No information about this author
Linping Yu
No information about this author
et al.
Journal of Materials Science,
Journal Year:
2025,
Volume and Issue:
unknown
Published: April 2, 2025
Language: Английский
Smart Bioelectronics for Real-Time Diagnosis and Therapy of Body Organ Functions
Lili Guo,
No information about this author
Hin Kiu Lee,
No information about this author
Suyoun Oh
No information about this author
et al.
ACS Sensors,
Journal Year:
2025,
Volume and Issue:
unknown
Published: May 1, 2025
Noncommunicable
diseases
(NCDs)
associated
with
cardiovascular,
neurological,
and
gastrointestinal
disorders
remain
a
leading
cause
of
global
mortality,
sounding
the
alarm
for
urgent
need
better
diagnostic
therapeutic
solutions.
Wearable
implantable
biointegrated
electronics
offer
groundbreaking
solution,
combining
real-time,
high-resolution
monitoring
innovative
treatment
capabilities
tailored
to
specific
organ
functions.
In
this
comprehensive
review,
we
focus
on
affecting
brain,
heart,
organs,
bladder,
adrenal
gland,
along
their
physiological
parameters.
Additionally,
provide
an
overview
characteristics
these
parameters
explore
potential
bioelectronic
devices
in
situ
sensing
applications
highlight
recent
advancements
deployment
across
organs.
Finally,
analyze
current
challenges
prospects
implementing
closed-loop
feedback
control
systems
integrated
sensor-therapy
applications.
By
emphasizing
organ-specific
advocating
systems,
review
highlights
future
bioelectronics
address
needs
serves
as
guide
researchers
navigating
interdisciplinary
fields
diagnostics,
therapeutics,
personalized
medicine.
Language: Английский
The 40th anniversary of the School of Materials Science and Engineering at Southeast University
Research,
Journal Year:
2024,
Volume and Issue:
7
Published: Jan. 1, 2024
In
recent
years,
one-dimensional
(1D)
implantable
sensors
have
received
considerable
attention
and
rapid
development
in
the
biomedical
field
due
to
their
unique
structural
characteristics
high
integration
capability.
These
can
be
implanted
into
human
body
with
minimal
invasiveness,
facilitating
real-time
accurate
monitoring
of
various
physiological
pathological
parameters.
This
review
examines
latest
advancements
1D
sensors,
focusing
on
material
design
device
integration,
implantation
methods,
construction
stable
sensor–tissue
interface.
Furthermore,
a
comprehensive
overview
is
provided
regarding
applications
future
research
directions
for
an
ultimate
aim
promote
utilization
personalized
healthcare
precision
medicine.
Language: Английский