Stereodivergent Hydrohalogenation of SCF3 Alkynes and Cross- Coupling Reactions DOI
Nicolas Marie,

Kim Uyen Ly,

Norio Shibata

et al.

Organic Letters, Journal Year: 2024, Volume and Issue: 26(42), P. 9168 - 9172

Published: Oct. 16, 2024

SCF

Language: Английский

A General Medium-to-Large Sized Ring Synthesis Enabled by Copper-Catalyzed Difluoroalkylamidation Cyclization of Alkynes DOI
Jing Ren, Linfeng He, Jinlong Li

et al.

Organic Letters, Journal Year: 2025, Volume and Issue: unknown

Published: May 9, 2025

This paper describes a novel coordinating activation strategy that enables the synthesis of medium-to-large sized rings (11-17 members) via an unprecedented difluoroalkylamidation cyclization alkynes. method provides efficient platform for accessing skeleton-diverse difluoroalkyl-containing cyclic enamides with complete regio- and stereoselectivity. The protocol features broad substrate compatibility, functional group tolerance, ease use at dilution concentrations (50 mM) are not high. Moreover, synthetic utility this difunctional is underscored by its application in late-stage modification complex molecules. Additionally, click reaction facilitates derivation alkynyl-substituted products, demonstrating methodology's potential biological sciences.

Language: Английский

Citations

0
Alkynyl Sulfide: An Unexplored yet Versatile Alkynyl Species for Chemoselective Cross-Electrophile Coupling DOI
Donghui Xing, Jinlin Liu, Liangbin Huang

et al.

Organic Letters, Journal Year: 2025, Volume and Issue: unknown

Published: May 23, 2025

The development of robust and readily available carbon electrophiles for cross-electrophile coupling (XEC) is important highly desirable. Herein, we report a cobalt-catalyzed chemoselective XEC between alkynyl sulfides various alkyl halides, which tolerates otherwise widely employed handles such as series aromatic (pseudo)halogens (Ar-I/Br/Cl/OTf/OTs/SMe) provides an easy efficient method synthesizing internal alkynes (>60 examples achieving up to 96% yields). Mechanistic studies have revealed that the leaving sulfide anion adjusts reactivity alkynyl-Co intermediates, enabling excellent chemoselectivity.

Language: Английский

Citations

0
Catalytic Asymmetric Hydrogen Atom Transfer Based on a Chiral Hydrogen Atom Donor Generated from TBADT and Chiral BINOL DOI
Ling Li, Shiqi Zhang, Xin Cui

et al.

Organic Letters, Journal Year: 2024, Volume and Issue: unknown

Published: Sept. 24, 2024

Enantioselective radical reactions mediated by TBADT have seldom been seen due to the inherent challenges. Herein, we disclose a new chiral hydrogen atom transfer (HAT) reagent that was generated easily from 8

Language: Английский

Citations

1
Visible-Light-Driven Synthesis of Alkenyl Thiocyanates: Novel Building Blocks for Diverse Sulfur-Containing Molecular Assembly DOI Creative Commons
Helena F. Piedra, Manuel Plaza

Chemical Science, Journal Year: 2024, Volume and Issue: unknown

Published: Jan. 1, 2024

A new photochemical method to prepare alkenyl thioethers under both batch and continuous flow conditions is presented. These versatile building blocks enable the synthesis of various organosulfur compounds, highlighting utility this procedure.

Language: Английский

Citations

1
Stereodivergent Hydrohalogenation of SCF3 Alkynes and Cross- Coupling Reactions DOI
Nicolas Marie,

Kim Uyen Ly,

Norio Shibata

et al.

Organic Letters, Journal Year: 2024, Volume and Issue: 26(42), P. 9168 - 9172

Published: Oct. 16, 2024

SCF

Language: Английский

Citations

0