Organic Letters, Journal Year: 2024, Volume and Issue: 26(42), P. 9168 - 9172
Published: Oct. 16, 2024
SCF
Language: Английский
Organic Letters, Journal Year: 2024, Volume and Issue: 26(42), P. 9168 - 9172
Published: Oct. 16, 2024
SCF
Language: Английский
Organic Letters, Journal Year: 2025, Volume and Issue: unknown
Published: May 9, 2025
This paper describes a novel coordinating activation strategy that enables the synthesis of medium-to-large sized rings (11-17 members) via an unprecedented difluoroalkylamidation cyclization alkynes. method provides efficient platform for accessing skeleton-diverse difluoroalkyl-containing cyclic enamides with complete regio- and stereoselectivity. The protocol features broad substrate compatibility, functional group tolerance, ease use at dilution concentrations (50 mM) are not high. Moreover, synthetic utility this difunctional is underscored by its application in late-stage modification complex molecules. Additionally, click reaction facilitates derivation alkynyl-substituted products, demonstrating methodology's potential biological sciences.
Language: Английский
Citations
0Organic Letters, Journal Year: 2025, Volume and Issue: unknown
Published: May 23, 2025
The development of robust and readily available carbon electrophiles for cross-electrophile coupling (XEC) is important highly desirable. Herein, we report a cobalt-catalyzed chemoselective XEC between alkynyl sulfides various alkyl halides, which tolerates otherwise widely employed handles such as series aromatic (pseudo)halogens (Ar-I/Br/Cl/OTf/OTs/SMe) provides an easy efficient method synthesizing internal alkynes (>60 examples achieving up to 96% yields). Mechanistic studies have revealed that the leaving sulfide anion adjusts reactivity alkynyl-Co intermediates, enabling excellent chemoselectivity.
Language: Английский
Citations
0Organic Letters, Journal Year: 2024, Volume and Issue: unknown
Published: Sept. 24, 2024
Enantioselective radical reactions mediated by TBADT have seldom been seen due to the inherent challenges. Herein, we disclose a new chiral hydrogen atom transfer (HAT) reagent that was generated easily from 8
Language: Английский
Citations
1Chemical Science, Journal Year: 2024, Volume and Issue: unknown
Published: Jan. 1, 2024
A new photochemical method to prepare alkenyl thioethers under both batch and continuous flow conditions is presented. These versatile building blocks enable the synthesis of various organosulfur compounds, highlighting utility this procedure.
Language: Английский
Citations
1Organic Letters, Journal Year: 2024, Volume and Issue: 26(42), P. 9168 - 9172
Published: Oct. 16, 2024
SCF
Language: Английский
Citations
0