Development of label-free light-controlled gene expression technologies using mid-IR and terahertz light

Frontiers in Bioengineering and Biotechnology, Journal Year: 2024, Volume and Issue: 12

Published: Oct. 11, 2024

Gene expression is a fundamental process that regulates diverse biological activities across all life stages. Given its vital role, there an urgent need to develop innovative methodologies effectively control gene expression. Light-controlled considered favorable approach because of ability provide precise spatiotemporal control. However, current light-controlled technologies rely on photosensitive molecular tags, making their practical use challenging. In this study, we review for and propose the development label-free using mid-infrared (mid-IR) terahertz light.

Language: Английский

Site-Specific Location of Black Phosphorus Quantum Dot Cluster-Based Nanocomplexes for Synergistic Ion Channel Therapy and Hypoxic Microenvironment Activated Chemotherapy

ACS Applied Materials & Interfaces, Journal Year: 2024, Volume and Issue: 16(39), P. 52059 - 52067

Published: Sept. 23, 2024

The spatiotemporal regulation of ion transport in living cell membrane channels has immense potential for providing novel therapeutic approaches the treatment currently intractable diseases. So far, most strategies suffer from uncontrolled and limited tumor therapy effects. On premise low toxicity to healthy tissues, enhancing degree overloading effect still remains a challenging concern. Herein, an innovative strategy synergistic channel hypoxic microenvironment activated chemotherapy is proposed. Biocompatible AQ4N/black phosphorus quantum dot clusters@liposomes (AQ4N/BPCs@Lip) nanocomplexes are site-specifically immobilized on by metabolic labeling strategy, eliminating need modifying or genetically encoding structures. Ascribing localized temperature increase BPCs under NIR light irradiation, Ca

Language: Английский