Alleviating NIR-II emission quenching in ring-fused fluorophore via manipulating dimer populations for superior fluorescence imaging

Light Science & Applications, Journal Year: 2025, Volume and Issue: 14(1)

Published: March 4, 2025

Emission quenching resulting from fluorophore aggregation has long been a significant challenge in optimizing emission-based technologies, such as fluorescence imaging and optoelectronic devices. Alleviating this aggregates is crucial, yet progress impeded by the limited understanding of nature impact on emission. Here, we elucidate critical role dimeric aggregate (dimer) alleviating second near-infrared (NIR-II, 900-1700 nm) emission ring-fused 4F for superior imaging. Spectral decomposition molecular dynamics simulations demonstrate predominance dimer populations aggregates. Notably, dimers exhibit significantly weaker but intense intermolecular nonradiative (interNR) decay compared to monomers, demonstrated ultrafast spectra quantum calculation. Therefore, predominant population with weak pronounced interNR feature underlies This discovery guides preparation ultrabright NIR-II nanofluorophore (4F NP3s) decreasing populations, which show 5-fold greater brightness than indocyanine green, enabling resolution visualizing blood vessels. work offers valuable insights into aggregation-caused quenching, broad implications extending far beyond

Language: Английский

Regulated cell death mechanisms in mitochondria-targeted phototherapy

Journal of Controlled Release, Journal Year: 2025, Volume and Issue: unknown, P. 113720 - 113720

Published: April 1, 2025

Language: Английский