Chemoenzymatic Dynamic Kinetic Resolution of Atropoisomeric 2-(Quinolin-8-yl)benzylalcohols DOI
Juan M. Coto‐Cid, Valentı́n Hornillos, Rosario Fernández

et al.

The Journal of Organic Chemistry, Journal Year: 2025, Volume and Issue: unknown

Published: April 9, 2025

The chemoenzymatic dynamic kinetic resolution of 2-(quinolin-8-yl)benzylalcohols using a combination lipases and ruthenium catalysts is described. While CalB lipase performs highly selective enzymatic resolution, the with Shvo's or Bäckvall's promotes atropisomerization substrate via reversible formation configurationally labile aldehydes, thereby enabling resolution. This synergistic approach was applied to synthesis variety heterobiaryl acetates in excellent yields enantioselectivities.

Language: Английский

Dynamic kinetic resolution and dynamic kinetic asymmetric transformation of atropisomeric biaryls DOI
Jie Zhang,

Xuan-Zhu Huo,

Yidan Liu

et al.

Chem Catalysis, Journal Year: 2025, Volume and Issue: unknown, P. 101329 - 101329

Published: March 1, 2025

Language: Английский

Citations

1
Chemoenzymatic Dynamic Kinetic Resolution of Atropoisomeric 2-(Quinolin-8-yl)benzylalcohols DOI
Juan M. Coto‐Cid, Valentı́n Hornillos, Rosario Fernández

et al.

The Journal of Organic Chemistry, Journal Year: 2025, Volume and Issue: unknown

Published: April 9, 2025

The chemoenzymatic dynamic kinetic resolution of 2-(quinolin-8-yl)benzylalcohols using a combination lipases and ruthenium catalysts is described. While CalB lipase performs highly selective enzymatic resolution, the with Shvo's or Bäckvall's promotes atropisomerization substrate via reversible formation configurationally labile aldehydes, thereby enabling resolution. This synergistic approach was applied to synthesis variety heterobiaryl acetates in excellent yields enantioselectivities.

Language: Английский

Citations

0