Light‐Activated Pharmacological Tools for Exploring the Cholinergic System
Alessio Colleoni,
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Giulia Galli,
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Clelia Dallanoce
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et al.
Medicinal Research Reviews,
Journal Year:
2025,
Volume and Issue:
unknown
Published: March 23, 2025
ABSTRACT
Cholinergic
transmission
plays
a
critical
role
in
both
the
central
and
peripheral
nervous
systems,
affecting
processes
such
as
learning,
memory,
inflammation.
Conventional
cholinergic
drugs
generally
suffer
from
poor
selectivity
temporal
precision,
leading
to
undesired
effects
limited
therapeutic
efficacy.
Photopharmacology
aims
overcome
limitations
of
traditional
using
photocleavable
or
photoswitchable
ligands
spatiotemporal
patterns
illumination.
Spanning
muscarinic
nicotinic
modulators
cholinesterase
inhibitors,
this
review
explores
development
application
light‐activated
compounds
tools
for
unraveling
signaling
physiological
pathological
contexts,
while
also
paving
way
innovative
phototherapeutic
approaches.
Language: Английский
32nd Annual GP2A Medicinal Chemistry Conference
Drugs and Drug Candidates,
Journal Year:
2025,
Volume and Issue:
4(1), P. 2 - 2
Published: Jan. 9, 2025
The
Group
for
the
Promotion
of
Pharmaceutical
Chemistry
in
Academia
(GP2A)
held
its
32nd
annual
conference
August
2024
at
University
Coimbra,
Portugal.
There
were
8
keynote
presentations,
12
early
career
researcher
oral
and
34
poster
presentations.
Four
awards
delivered,
two
best
communications
Language: Английский