Boosting Tumor Apoptosis and Ferroptosis with Multienzyme Mimetic Au Single‐Atom Nanozymes Engaged in Cascade Catalysis DOI
Ziyi Wang,

Runan Chen,

Wenying Zhang

et al.

Advanced Functional Materials, Journal Year: 2024, Volume and Issue: unknown

Published: Oct. 1, 2024

Abstract Nanozyme‐based catalytic therapy has garnered much attention in cancer treatment for converting endogenous substrates into reactive oxygen species (ROS), which induce oxidative stress damage tumors. However, the effectiveness of nanozymes is hindered by limited availability these tumor microenvironment. To address this, a novel gold‐based single‐atom nanozyme (AuSAN), glucose oxidase (GOx, G), and lactate (LOx, L) are meticulously engineered highly ordered biomimetic composite M/GLB@AuSAN, forming an interconnected cascade catalysis that catalyzes carbon sources ROS as sustained antitumor strategy. The loaded GOx LOx aerobically catalyze to produce H 2 O , then rapidly converted ·OH, •− AuSAN. generated serves positive feedback substrate further GOx‐ LOx‐mediated aerobic catalysis, significantly amplifying thereby enhancing accumulation. abundant intracellular scarce effectively exacerbate protein phosphorylation, lipid peroxidation, mitochondrial damage, ultimately provoking apoptosis ferroptosis vitro vivo. Therefore, integrated design GOx/LOx/AuSAN provides promising strategy combine multiple enzymatic activities, deplete sources, enhance production, resulting suppression melanoma progression.

Language: Английский

The smartphone-assisted sensing platform based on manganese dioxide nanozymes for the specific detection and degradation of hydroquinone DOI
Dong Wang, Yuan Zhang, Xiaoting Li

et al.

Journal of Hazardous Materials, Journal Year: 2025, Volume and Issue: 487, P. 137133 - 137133

Published: Jan. 7, 2025

Language: Английский

Citations

1
New horizons for the therapeutic application of nanozymes in cancer treatment DOI Creative Commons
Pravanjan Malla, Yu‐Ming Wang, Chia‐Hao Su

et al.

Journal of Nanobiotechnology, Journal Year: 2025, Volume and Issue: 23(1)

Published: Feb. 20, 2025

The advent of nanozymes has revolutionized approaches to cancer diagnosis and therapy, introducing innovative strategies that address the limitations conventional treatments. Nanozyme nanostructures with enzyme-mimicking catalytic abilities exhibit exceptional stability, biocompatibility, customizable functions, positioning them as promising tools for theranostics. By emulating natural enzyme reactions, can selectively target eradicate cells, minimizing harm adjacent healthy tissues. Nanozymes also be functionalized specific targeting ligands, allowing precise delivery regulated release therapeutic agents, improving treatment effectiveness reducing adverse effects. However, issues such selectivity, regulatory compliance remain critical challenges clinical application nanozymes. This review provides an overview nanozymes, highlighting their unique properties, various classifications, activities, diverse applications in strategic oncological deployment could profoundly impact future advancements personalized medicine, recent progress prospective directions enzyme-mimetic treatment. summarizes

Language: Английский

Citations

1
Nanozymes with Modulable Inhibition Transfer Pathways for Thiol and Cell Identification DOI
Lijun Hu, Lei Jiao, Chengjie Chen

et al.

Analytical Chemistry, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 13, 2025

The elementary mechanism and site studies of nanozyme-based inhibition reactions are ambiguous urgently require advanced nanozymes as mediators to elucidate the effect. To this end, we develop a class featuring single Cu–N catalytic configurations B–O sites binding on porous nitrogen-doped carbon substrate (B6/CuSA) for inducing modulable transfer at atomic level. full redistribution electrons across sites, induced by incorporation, yields B6/CuSA with enhanced peroxidase-like activity versus CuSA. More importantly, CuSA features in cysteine expresses competitive through coordination bonds, an constant 0.048 mM. Benefiting from way nanozymes, possesses mixed approaches noncovalent bonds delivers record-mixed interaction 0.054 mM noncompetitive 0.71 Based CuSA, multichannel sensor array accomplishes detection various cancer cells, normal thiols. design principle work is endowed guidelines preliminary evaluation massive potential thiols, cell discrimination, disease prediction.

Language: Английский

Citations

0
Coordination-Driven Room-Temperature Phosphorescent Carbon Dot Nanozymes for Dual-Mode Glutathione Detection DOI

Meng-Xian Liu,

Xiao Zhang,

Wen-Ye Liu

et al.

Talanta, Journal Year: 2025, Volume and Issue: 290, P. 127833 - 127833

Published: Feb. 25, 2025

Language: Английский

Citations

0
Cu–Zn@HA bimetallic nanozymes: a novel approach for ROS clearance and macrophage polarization in colitis therapy DOI Creative Commons

Cheng Lin,

Yuzhou Dai,

Ningyi Zhang

et al.

Advanced Composites and Hybrid Materials, Journal Year: 2025, Volume and Issue: 8(2)

Published: March 4, 2025

Language: Английский

Citations

0
Boosting Peroxidase-Mimetic Activity of FeMn-NCe Dual-Atom Radiosensitizing Nanozymes for Augmented Radiodynamic Immunotherapy DOI
Bo Chen, Yinggang Wang,

Min Mu

et al.

ACS Nano, Journal Year: 2025, Volume and Issue: unknown

Published: March 7, 2025

Dual-atom nanozymes (DAzymes) have garnered considerable attention as catalysts for reactive oxygen species (ROS)-based therapies, effectively leveraging ROS generation within the tumor microenvironment (TME). Herein, we introduce FeMn-NCe DAzymes, which are meticulously engineered enhanced peroxidase (POD)-mimetic activity and potent radiosensitization to advance radioimmunotherapy. Density functional theory (DFT) calculations reveal that DAzymes lower energy barrier increase substrate affinity, enabling highly efficient catalytic performance. Within TME, these efficiently convert overexpressed hydrogen peroxide (H2O2) into hydroxyl radicals (•OH), potentially activating cGAS-STING immune pathway. This POD-mimetic catalysis is further accelerated under X-ray irradiation, significantly enhancing radiosensitization. Additionally, a uniform coating of ultrasmall gold nanoparticles on enhances absorption cancer cells. The incorporation STING agonist diABZI onto induces long-term antitumor immunity, reprograms immunosuppressive suppresses growth metastasis following single low-dose treatment. work highlights valuable strategy designing radiodynamic immunotherapy.

Language: Английский

Citations

0
Microenvironment‐Responsive Injectable Thermosensitive Hydrogel Incorporating Nanozymes for Synergistic Breast Cancer Therapy and Postsurgical Adjuvant Treatment DOI
Peng Hu, Na Feng, Shuang Zhao

et al.

Advanced Functional Materials, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 23, 2025

Abstract Tumor recurrence and wound infection present significant challenges to patient recovery following surgery, underscoring the need for effective therapeutic strategies improve prognosis by mitigating these complications. This study introduces novel synthesis methods honeycomb‐like CuMnOx nanozymes CuO 2 nanoflowers with multienzymatic activity pH‐responsive properties. The enzymatic activities of can be regulated pH changes in tumor or microenvironments, while overcome limitation insufficient endogenous H O release ROS weakly acidic conditions. To realize their synergistic effects, nanozymes, along photothermal agent IR820, are co‐assembled into low‐melting point agarose solution, forming a thermosensitive nanozyme‐based hydrogel (CuMnOx@CuO @IR820 hydrogel, CMCI Gel), which facilitates controlled drug delivery exerts enhanced efficiency under low‐temperature therapy (LTPTT, <48 °C). In vitro vivo studies demonstrated that Gel effectively ablated cells range bacteria, including drug‐resistant bacteria like MRSA . Furthermore, it reduces inflammation, promotes vascular regeneration collagen deposition, accelerates healing. injectability thermosensitivity allow localized treatment, minimizing systemic side effects. Overall, benefits highlight as promising adjunctive prevent postsurgery infection.

Language: Английский

Citations

0
Synergistic Optimization of Electron Layout at Spatially Adjacent Dual-atom Sites Promotes Regeneration of Nanozymes and Deep Removal of Paracetamol DOI
Xinxin Lv, Xing Chen, Yao Liu

et al.

Applied Catalysis B Environment and Energy, Journal Year: 2025, Volume and Issue: unknown, P. 125256 - 125256

Published: March 1, 2025

Language: Английский

Citations

0
NIR-activatable proenzyme DSF/CuS@M for synergistic in situ chemotherapy/CDT/PTT/cuproptosis-based antitumor therapy DOI

Lushuang Xu,

Qinyue Chen,

Yangwei Qian

et al.

Chemical Engineering Journal, Journal Year: 2025, Volume and Issue: unknown, P. 161733 - 161733

Published: March 1, 2025

Language: Английский

Citations

0
S-Modified MOF Nanozyme Cascade System with Multi-Enzyme Activity for Dual-Mode Antibiotic Assay DOI

Yunsen Wang,

Shuo Tian,

Shuyun Chen

et al.

Analytical Chemistry, Journal Year: 2025, Volume and Issue: unknown

Published: March 25, 2025

The judicious utilization of antibiotics has established a robust bulwark for human health. However, their improper usage engendered deleterious ramifications on the environment, underscoring imperative developing efficacious and cost-effective detection degradation platforms. This study presents sulfur-modified iron-cobalt bimetallic single-atom nitrogen-doped carbon catalyst (S-FeCo-NC) with noncopper active center. In contrast to conventional laccase, which utilizes copper as its center, S-FeCo-NC exhibits multiple enzyme activities, including laccase-like, peroxidase-like, catalase-like functions, iron cobalt serving centers. As proof concept, combined laccase-like functions were used independent signal outputs, while multienzyme cascade dual-mode assay system was designed rapid tetracycline (TC) in combination peroxidase-like enzymes. this system, oxygen directly participated catalytic process an electron acceptor, peroxidase efficiently catalyzed production O2 from H2O2. elevated concentration offered unique advantage increased activity enzyme, outputs visually resolved colorimetric signals using stable 4-aminopyridine oxidized TC. Furthermore, generation OH radicals strong oxidative properties, these carried out effective decomposition output response performed differential pulse cyclic voltammetry, further improved sensitivity accuracy detection. experimental findings demonstrate that favorable TC within range 0.005-500 μM, reaching 0.5-500 0.005-1.00 respectively, limit is low 0.22 μM 1.68 nM, respectively. based activity, been shown significantly enhance also demonstrating stability lower range. suggests it may offer novel approach sensitive environmental pollutants.

Language: Английский

Citations

0