Dynamic Kinetic Reductive Grignard-Type Addition for the Construction of Axial and Central Chirality

ACS Catalysis, Journal Year: 2025, Volume and Issue: unknown, P. 1147 - 1157

Published: Jan. 3, 2025

This study describes a photoredox/cobalt dual-catalyzed asymmetric Grignard-type addition reaction, enabling the synthesis of axially chiral hexatomic (six–six) N-heterobiaryls bearing extra secondary alcohol unit via an efficient dynamic kinetic transformation racemic N-heterobiaryl triflate substrates. The conversion facilitated both photoredox and classical reductive reaction conditions exhibits good functional group tolerance, broad substrate scope, satisfactory stereoselectivity. Furthermore, control experiments density theory calculations provide preliminary mechanistic insights.

Language: Английский

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Dynamic kinetic resolution and dynamic kinetic asymmetric transformation of atropisomeric biaryls

Chem Catalysis, Journal Year: 2025, Volume and Issue: unknown, P. 101329 - 101329

Published: March 1, 2025

Language: Английский

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Modular Assembly of Axially Chiral QUINAP Derivatives via Nickel-Catalyzed Enantioselective C–P Cross-Coupling

ACS Catalysis, Journal Year: 2025, Volume and Issue: unknown, P. 8268 - 8273

Published: May 2, 2025

Language: Английский

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Synergistic photoredox/palladium catalysis enables enantioconvergent carboxylation of racemic heterobiaryl (pseudo)halides with CO₂

Chemical Synthesis, Journal Year: 2024, Volume and Issue: 4(4)

Published: Oct. 19, 2024

Language: Английский

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