Self‐Assembled Fluorescent Peptide Nanoprobes for Disease Diagnosis DOI
Ruichen Wang, Tao Xi, Kaixuan Li

et al.

Small Methods, Journal Year: 2025, Volume and Issue: unknown

Published: June 1, 2025

Abstract Benefiting from the advantages of simple reactions, low energy consumption, and uniform properties, self‐assembly has been widely utilized for preparation nanoprobes. Peptides have chosen as “bricks” self‐assembling nano‐biomaterials due to their easy drug formation, highly variable sequence, good biocompatibility biodegradability. can efficiently self‐assemble through noncovalent interactions, such hydrogen bonding, electrostatic π–π stacking, hydrophobic van der Waals forces. Based on this, many ex situ in strategies are developed. The former self‐assembles into stable nanomaterials beforehand, while latter undergoes at target site response its specific stimulus‐responsive modules. As probe sizes miniaturized nanometer scale, they gain high sensitivity, detection limits, capability detection. Nanoprobes created self‐assembly, usually possess targeted accumulation tissues, prolonged elimination half‐life, multimodal imaging capabilities, making them effective disease diagnosis. This review introduces types self‐assembled fluorescent peptide nanoprobes according source fluorescence properties summarizes progress application diagnosis, cancer, neurodegenerative disease, bacterial infection. In addition, limitations will be discussed, new proposed development advanced peptide‐based nanoprobes, aimed improving potential clinical translation.

Language: Английский

Self-assembled Nanostructures of Noncovalent Giant Amphiphilic Molecules Composed of Hydrophobic Isobutyl BPOSS and Hydrophilic POM in Different Cosolvents DOI
Fengfeng Feng,

Dongcheng Xiao,

Fan Yang

et al.

Langmuir, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 21, 2025

The self-assembly of giant amphiphilic molecules with diverse topological structures has been widely investigated in bulk, solution, and interfacial environments because it can lead to interesting geometric patterns. However, many or their self-assembling units are built by covalent bonds, which may limit the movement molecular blocks, affecting process microstructure. In contrast, noncovalent interactions nanomorphologies nanostructures. this study, we (BPOSS&POM) forming electrostatic between hydrophobic isobutyl polyhedral oligomeric silsesquioxanes (BPOSSs) hydrophilic polyoxometalates (POMs) investigate behavior water/acetone, water/THF, hexane/acetone cosolvents. By controlling solvent parameters, BPOSS&POM self-assembled into nanosheet, nanobelt, nanosphere, nanocrumb structures. morphology detailed nanostructure different self-assemblies were revealed performing transmission electron microscopy (TEM), scanning (SEM), small-angle X-ray scattering (SAXS) measurements. TEM SAXS results indicated that microphase exhibited a lamellar structure an interlayer distance about 3 nm. was alternatively organized layers BPOSS POM according size dimension. polarity solvents substantially affected nanoassemblies but not aggregation POM. This research offers insights preparation nanomaterials micromorphologies simply adjusting solution components.

Language: Английский

Citations

0
Regulating Enol-to-Keto Tautomerization of Pillararene-Based Conjugated Macrocycle Polymers for H2O2 Photosynthesis DOI

Zhuo-Qin Wang,

Menghao Li, Shuang Liang

et al.

Journal of the American Chemical Society, Journal Year: 2025, Volume and Issue: unknown

Published: April 10, 2025

Porous organic polymers have emerged as promising materials for energy conversion, pollutant adsorption, and heterogeneous catalysis because of their tunable pore structures high surface areas. However, most porous are still limited by insufficient conjugation inefficient electron-hole separation, hindering the tunability photoelectric properties overall functionality. By integrating macrocyclic compounds a new building block, which feature electron-rich cavities rigid ring structures, into polymer network, resulting conjugated macrocycle expected to provide an innovative approach enrich functionalities polymers. Herein, enaminone-based pillararene photocatalyst, TpAP[5], is constructed covalently linking functionalized pillar[5]arene through Schiff base condensation efficient photocatalytic reactions. This material demonstrates exceptional performance in production hydrogen peroxide, achieving rate 2343 μmol g-1 h-1. In-depth investigations reveal that incorporation pillararenes enables synergistic water oxidation oxygen reduction reactions significantly enhances catalyst stability regulating molecular tautomerization. work opens avenues designing high-performance multifunctional with significant potential clean conversion.

Language: Английский

Citations

0
Anthracene and pyrene containing fluorescent metallacycles/cages (MOCs) and their applications DOI Creative Commons

Jiaxing Du,

Meng Yu, Wei Tuo

et al.

APL Materials, Journal Year: 2025, Volume and Issue: 13(5)

Published: May 1, 2025

Metal–organic cycle/cages (MOCs) are a class of molecular structures characterized by their unique shapes and dimensions, created using the systematic combination an organic donor metal center. Due to versatile properties, MOCs highly useful in materials science. Owing structural photoelectric polycyclic aromatic hydrocarbons have significant application potential optoelectronic devices, chemical sensing, biomedical fields. Fluorescent constructed with units such as anthracene pyrene backbones show fluorescence properties broad applications recognition, bioimaging, functional materials. This review highlights latest research progress on these multiple areas, including luminescence, resonance energy transfer, host–guest chemistry, bioimaging. In addition, design strategies related involving conformational distortions cycloaddition reactions discussed. provides summary advances this field during past three years.

Language: Английский

Citations

0
Sensitive discrimination of hazardous explosives by a sensor array based on siloles with aggregate-induced emission DOI

Hongbin Zhou,

Shengwen Yang, Fei Chen

et al.

Spectrochimica Acta Part A Molecular and Biomolecular Spectroscopy, Journal Year: 2025, Volume and Issue: 341, P. 126386 - 126386

Published: May 10, 2025

Language: Английский

Citations

0
Chiral Amplification and Regulation: Design and Applications of Circularly Polarized Luminescence‐Active Materials Derived From Macrocyclic Compounds DOI Creative Commons
Wei Zhang,

Mao‐Qin Liu,

Yang Luo

et al.

Aggregate, Journal Year: 2025, Volume and Issue: unknown

Published: May 9, 2025

ABSTRACT Chirality is a fundamental property in molecules and biological systems, characterized by asymmetric configurational features. Circularly polarized luminescence (CPL) materials have gained significant attention due to their unique optical activities, with applications 3D displays, chiral sensors, catalysis, more. Chiral transfer amplification typically involve the generation of chirality excited state, facilitated interactions like energy transfer, electron or induction. Supramolecular self‐assembly strategies, particularly macrocyclic compounds, enable linking achiral luminescent units through intermolecular interactions. Macrocyclic hosts—cyclodextrins, calix[ n ]arenes, pillar[ cyclophanes, cucurbit[ ]urils—are especially promising stable structures adjustable cavities for guest encapsulation. These compounds induce photophysical properties host–guest complexation, making them ideal constructing amplification, CPL‐active materials. This review summarizes advancements multicolor CPL materials, sensing, induction, separation, highlighting potential supramolecular material design. The challenges future directions this field are also discussed, aiming guide further research application systems.

Language: Английский

Citations

0
Self‐Assembled Fluorescent Peptide Nanoprobes for Disease Diagnosis DOI
Ruichen Wang, Tao Xi, Kaixuan Li

et al.

Small Methods, Journal Year: 2025, Volume and Issue: unknown

Published: June 1, 2025

Abstract Benefiting from the advantages of simple reactions, low energy consumption, and uniform properties, self‐assembly has been widely utilized for preparation nanoprobes. Peptides have chosen as “bricks” self‐assembling nano‐biomaterials due to their easy drug formation, highly variable sequence, good biocompatibility biodegradability. can efficiently self‐assemble through noncovalent interactions, such hydrogen bonding, electrostatic π–π stacking, hydrophobic van der Waals forces. Based on this, many ex situ in strategies are developed. The former self‐assembles into stable nanomaterials beforehand, while latter undergoes at target site response its specific stimulus‐responsive modules. As probe sizes miniaturized nanometer scale, they gain high sensitivity, detection limits, capability detection. Nanoprobes created self‐assembly, usually possess targeted accumulation tissues, prolonged elimination half‐life, multimodal imaging capabilities, making them effective disease diagnosis. This review introduces types self‐assembled fluorescent peptide nanoprobes according source fluorescence properties summarizes progress application diagnosis, cancer, neurodegenerative disease, bacterial infection. In addition, limitations will be discussed, new proposed development advanced peptide‐based nanoprobes, aimed improving potential clinical translation.

Language: Английский

Citations

0