Push-Pull OPEs in Blue-Light Anticancer Photodynamic Therapy DOI Creative Commons

Ana Lameiro,

Chiara M. A. Gangemi, Aurora Mancuso

et al.

Molecules, Journal Year: 2025, Volume and Issue: 30(11), P. 2310 - 2310

Published: May 24, 2025

Photodynamic therapy (PDT) is a minimally invasive technique—used for the local eradication of neoplastic cells—that exploits interaction light, oxygen, and photo-responsive drug called photosensitizer (PS) generation lethal ROS. Push-pull chromophores, that bear electron donor (D) acceptor (A) groups linked through π-electron bridge, are characterized by non-homogeneous charge distribution in their excited state, with transfer from one extremity chain to other (Internal Charge Transfer—ICT). This phenomenon has direct impact on photophysical features push-pull compounds, as bathochromic shift emission maxima intersystem crossing (ISC) state directly connected production reactive oxygen species (ROS). In continuing our research regarding synthesis use oligophenylene ethynylenes (OPEs) PDT, two new glycosyl OPE-NOF OPE-ONF—featuring electron-donor N,N-dimethylamino (N) dimetoxyaryl (O) tetrafluoroaryl (F) moieties OPE chain—have been efficiently prepared. The interchanged position D onto conjugated skeleton was aimed tune optimize effect, while introduction glucoside terminations directed give biocompatibility bioaffinity chromophores. OPE-NOF, OPE-ONF, synthetic intermediates were fully characterized, properties investigated using UV-Vis absorption spectroscopy. showed strong charge-transfer character high PDT effect HeLa cancer cells when irradiated non-harmful blue causing massive cell death.

Language: Английский

Spatio‐Temporally Profiling Human Lung Cancer Surgery With a FRET‐Mediated AIEgen‐Active Nanoprobe DOI
Yifan He,

Yongkang Yao,

Chenxu Yan

et al.

Advanced Functional Materials, Journal Year: 2025, Volume and Issue: unknown

Published: May 15, 2025

Abstract Fluorescent surgical navigation is a clinically approved modality that has shown great potential for cancer treatment. However, its application in lung tumors still faces long‐standing challenges because the location, size, and shape of can fluctuate significantly depending on lung's gas filling or expulsion state. This leads to substantial gap between preoperative imaging evaluation intraoperative feedback. Herein, Förster resonance energy transfer (FRET)‐mediated aggregation‐induced emission (AIE)‐active nanoprobe TCM‐N&Cy&Fe@P described spatiotemporally profiling surgery through dual‐modal magnetic (MRI)/fluorescent imaging. strategy, first time, effectively addresses information‐gap across pre‐, intra‐, post‐operative stages surgery: MRI provides high spatial resolution soft tissue images assessment cancer. After targeted delivery tumor site, disassembly resulted significant enhancement near‐infrared fluorescence. Such AIE‐active fluorescence offers temporal precisely recognizing delineating boundaries freshly excised tissues from patients, postoperatively pathological staining with tumor‐to‐normal contrast.

Language: Английский

Citations

0
Push-Pull OPEs in Blue-Light Anticancer Photodynamic Therapy DOI Creative Commons

Ana Lameiro,

Chiara M. A. Gangemi, Aurora Mancuso

et al.

Molecules, Journal Year: 2025, Volume and Issue: 30(11), P. 2310 - 2310

Published: May 24, 2025

Photodynamic therapy (PDT) is a minimally invasive technique—used for the local eradication of neoplastic cells—that exploits interaction light, oxygen, and photo-responsive drug called photosensitizer (PS) generation lethal ROS. Push-pull chromophores, that bear electron donor (D) acceptor (A) groups linked through π-electron bridge, are characterized by non-homogeneous charge distribution in their excited state, with transfer from one extremity chain to other (Internal Charge Transfer—ICT). This phenomenon has direct impact on photophysical features push-pull compounds, as bathochromic shift emission maxima intersystem crossing (ISC) state directly connected production reactive oxygen species (ROS). In continuing our research regarding synthesis use oligophenylene ethynylenes (OPEs) PDT, two new glycosyl OPE-NOF OPE-ONF—featuring electron-donor N,N-dimethylamino (N) dimetoxyaryl (O) tetrafluoroaryl (F) moieties OPE chain—have been efficiently prepared. The interchanged position D onto conjugated skeleton was aimed tune optimize effect, while introduction glucoside terminations directed give biocompatibility bioaffinity chromophores. OPE-NOF, OPE-ONF, synthetic intermediates were fully characterized, properties investigated using UV-Vis absorption spectroscopy. showed strong charge-transfer character high PDT effect HeLa cancer cells when irradiated non-harmful blue causing massive cell death.

Language: Английский

Citations

0