Electrochemically induced Meerwein arylation as a green strategy for the synthesis of arylbenzoquinone derivatives under batch and flow conditions
Research Square (Research Square),
Journal Year:
2025,
Volume and Issue:
unknown
Published: April 10, 2025
Abstract
An
electrochemical
Meerwein
arylation
reaction
was
reported
for
the
synthesis
of
aryl-benzoquinone
derivatives.
In
this
work,
efficient
derivatives
by
direct
electrolysis
aqueous
solution
containing
hydroquinone
and
aryldiazonium
salts
in
batch
a
homemade
continuous-flow
cells
is
reported.
system,
products
were
obtained
simple
undivided
cell
equipped
with
copper
anode
stainless
steel
cathode.
continuous
flow
simply
passing
salt
through
tube
made
rod
center.
All
equipment
required
both
types
from
common
commercial
sources.
This
protocol
green
cost-effective
due
to
use
electricity
performed
under
mild
safe
conditions
without
toxic
solvents
catalysts.
Language: Английский
Electrochemically induced Meerwein arylation as a green strategy for the synthesis of arylbenzoquinone derivatives under batch and flow conditions
Scientific Reports,
Journal Year:
2025,
Volume and Issue:
15(1)
Published: May 17, 2025
An
electrochemical
Meerwein
arylation
reaction
was
reported
for
the
synthesis
of
aryl-benzoquinone
derivatives.
In
this
work,
efficient
derivatives
by
direct
electrolysis
aqueous
solution
containing
hydroquinone
and
aryldiazonium
salts
in
batch
a
homemade
continuous-flow
cells
is
reported.
system,
products
were
obtained
simple
undivided
cell
equipped
with
copper
anode
stainless
steel
cathode.
continuous
flow
simply
passing
salt
through
tube
made
rod
center.
All
equipment
required
both
types
from
common
commercial
sources.
This
protocol
green
cost-effective
due
to
use
electricity
performed
under
mild
safe
conditions
without
toxic
solvents
catalysts.
Language: Английский
Comprehensive electrochemical study of clonazepam an anticonvulsant benzodiazepine drug and its main metabolite. Green late-stage functionalization of clonazepam
Zahra Godini,
No information about this author
Davood Nematollahi,
No information about this author
Niloofar Mohamadighader
No information about this author
et al.
Research Square (Research Square),
Journal Year:
2025,
Volume and Issue:
unknown
Published: May 7, 2025
Abstract
The
electrochemical
synthesis
of
new
benzodiazepine
derivatives,
via
late-stage
modification
clonazepam
(
CZP),
a
anticonvulsant
drug,
is
one
the
two
main
objectives
this
research.
To
achieve
goal,
oxidation
drug
was
carried
out
in
presence
arylsulfinic
acid
derivatives
(
ASA)
an
undivided
cell
equipped
with
graphite
anode
and
cathode,
water/ethanol
mixture,
under
controlled
potential
conditions.
In
method,
benzodiazepines
were
synthesized
easy
workup
environmentally
friendly
conditions
without
need
for
catalysts,
reagents,
or
toxic
solvents,
at
room
temperature
pressure.
another
part
research,
behavior
CZP
thoroughly
investigated
information
reported
on
reaction
mechanism,
major
metabolite
CZP,
relationship
between
pH.
proposed
mechanism
involves
sequential
reduction
cathode
anode,
respectively,
followed
by
nucleophile
(
ASA).
addition,
docking
studies
performed
compounds
it
found
that
can
interact
well
gamma-aminobutyric
agonist
(
GABA).
Language: Английский