Comprehensive electrochemical study of clonazepam an anticonvulsant benzodiazepine drug and its main metabolite. Green late-stage functionalization of clonazepam DOI

Zahra Godini,

Davood Nematollahi,

Niloofar Mohamadighader

et al.

Research Square (Research Square), Journal Year: 2025, Volume and Issue: unknown

Published: May 7, 2025

Abstract The electrochemical synthesis of new benzodiazepine derivatives, via late-stage modification clonazepam (CZP), a anticonvulsant drug, is one the two main objectives this research. To achieve goal, oxidation drug was carried out in presence arylsulfinic acid derivatives (ASA) an undivided cell equipped with graphite anode and cathode, water/ethanol mixture, under controlled potential conditions. In method, benzodiazepines were synthesized easy workup environmentally friendly conditions without need for catalysts, reagents, or toxic solvents, at room temperature pressure. another part research, behavior CZP thoroughly investigated information reported on reaction mechanism, major metabolite CZP, relationship between pH. proposed mechanism involves sequential reduction cathode anode, respectively, followed by nucleophile (ASA). addition, docking studies performed compounds it found that can interact well gamma-aminobutyric agonist (GABA).

Language: Английский

Electrochemically induced Meerwein arylation as a green strategy for the synthesis of arylbenzoquinone derivatives under batch and flow conditions DOI
Davood Nematollahi, Masoumeh Malmir,

Ali Sadatnabi

et al.

Research Square (Research Square), Journal Year: 2025, Volume and Issue: unknown

Published: April 10, 2025

Abstract An electrochemical Meerwein arylation reaction was reported for the synthesis of aryl-benzoquinone derivatives. In this work, efficient derivatives by direct electrolysis aqueous solution containing hydroquinone and aryldiazonium salts in batch a homemade continuous-flow cells is reported. system, products were obtained simple undivided cell equipped with copper anode stainless steel cathode. continuous flow simply passing salt through tube made rod center. All equipment required both types from common commercial sources. This protocol green cost-effective due to use electricity performed under mild safe conditions without toxic solvents catalysts.

Language: Английский

Citations

0
Electrochemically induced Meerwein arylation as a green strategy for the synthesis of arylbenzoquinone derivatives under batch and flow conditions DOI Creative Commons
Masoumeh Malmir, Davood Nematollahi,

Ali Sadatnabi

et al.

Scientific Reports, Journal Year: 2025, Volume and Issue: 15(1)

Published: May 17, 2025

An electrochemical Meerwein arylation reaction was reported for the synthesis of aryl-benzoquinone derivatives. In this work, efficient derivatives by direct electrolysis aqueous solution containing hydroquinone and aryldiazonium salts in batch a homemade continuous-flow cells is reported. system, products were obtained simple undivided cell equipped with copper anode stainless steel cathode. continuous flow simply passing salt through tube made rod center. All equipment required both types from common commercial sources. This protocol green cost-effective due to use electricity performed under mild safe conditions without toxic solvents catalysts.

Language: Английский

Citations

0
Comprehensive electrochemical study of clonazepam an anticonvulsant benzodiazepine drug and its main metabolite. Green late-stage functionalization of clonazepam DOI

Zahra Godini,

Davood Nematollahi,

Niloofar Mohamadighader

et al.

Research Square (Research Square), Journal Year: 2025, Volume and Issue: unknown

Published: May 7, 2025

Abstract The electrochemical synthesis of new benzodiazepine derivatives, via late-stage modification clonazepam (CZP), a anticonvulsant drug, is one the two main objectives this research. To achieve goal, oxidation drug was carried out in presence arylsulfinic acid derivatives (ASA) an undivided cell equipped with graphite anode and cathode, water/ethanol mixture, under controlled potential conditions. In method, benzodiazepines were synthesized easy workup environmentally friendly conditions without need for catalysts, reagents, or toxic solvents, at room temperature pressure. another part research, behavior CZP thoroughly investigated information reported on reaction mechanism, major metabolite CZP, relationship between pH. proposed mechanism involves sequential reduction cathode anode, respectively, followed by nucleophile (ASA). addition, docking studies performed compounds it found that can interact well gamma-aminobutyric agonist (GABA).

Language: Английский

Citations

0