Separations,
Journal Year:
2022,
Volume and Issue:
9(5), P. 118 - 118
Published: May 11, 2022
A
simple
analytical
approach
based
on
capillary
zone
electrophoresis
with
ultraviolet
detection
and
repeated
sample
injection
strategy
(applied
in
a
hydrodynamically
closed
separation
system
for
the
first
time)
was
developed
determination
of
ibuprofen
(IBU)
commercially
available
pharmaceutical
preparations.
The
proposed
method
characterized
by
significantly
increased
throughput
favorable
validation
parameters,
highly
demanded
routine
quality
control
laboratories.
limit
predicted
at
concentration
level
0.31
µg/mL.
Intra-day
precision
expressed
as
relative
standard
deviation
IBU
ranged
from
1.9
to
5.6%,
corresponding
intra-day
accuracy
error
interval
87.1–106.5%.
Inter-day
range
2.6–15.0%,
inter-day
94.9–102.7%.
able
quantify
complex
matrices
represented
tablets
oral
suspension.
determined
contents
tested
dosage
forms
were
good
agreement
manufacturer’s
declaration.
performance
evaluated
according
innovative
RGB
Additive
Color
Model
strategy.
It
demonstrated
that
is
very
safety
eco-friendliness,
practical
effectiveness.
Analytical Science Advances,
Journal Year:
2021,
Volume and Issue:
2(3-4), P. 109 - 127
Published: Jan. 28, 2021
Abstract
High
throughput
experimentation
is
a
growing
and
evolving
field
that
allows
to
execute
dozens
several
thousands
of
experiments
per
day
with
relatively
limited
resources.
Through
miniaturization,
typically
high
degree
automation
the
use
digital
data
tools,
many
parallel
reactions
or
at
time
can
be
run
in
such
workflows.
also
requires
fast
analytical
techniques
capable
generating
critically
important
line
increased
rate
experimentation.
As
traditional
usually
do
not
deliver
speed
required,
some
unique
approaches
are
required
enable
workflows
function
as
designed.
This
review
covers
recent
developments
(2019‐2020)
this
was
intended
give
comprehensive
overview
current
“state‐of‐the‐art.”
Expert Opinion on Drug Discovery,
Journal Year:
2022,
Volume and Issue:
17(7), P. 775 - 787
Published: May 28, 2022
Acoustic
ejection
mass
spectrometry
(AEMS)
is
an
electrospray
ionization-mass
(ESI-MS)
based
analytical
platform
that
provides
high
throughput
and
data
quality.
It
has
been
applied
in
numerous
drug
discovery
workflows,
such
as
high-throughput
screening
(HTS),
absorption,
distribution,
metabolism,
excretion
(ADME)
profiling,
pharmacokinetics
(PK)
analysis,
compound
quality
control
(QC),
the
readout
of
medical
chemistry
samples.This
paper
introduces
working
principle
AEMS
technology.
The
performance,
system
tuning
method
development
representative
applications
on
assays
are
introduced.The
fast
sample
speed,
reproducibility,
wide
coverage,
minimum
carryover,
tolerance
to
complex
matrices
have
demonstrated
its
advantages
over
other
technologies
this
field,
with
broad
applicability
a
diverse
range
workflows.
However,
current
still
challenges
for
some
due
having
less
sensitivity
compared
liquid
chromatography-mass
(LC-MS),
lack
chromatographic
separation
isomeric
interferences.
Despite
remaining
hurdles,
becoming
attractive
discovery.
Additional
developments
would
enable
further
adoption
future.
Chemosensors,
Journal Year:
2022,
Volume and Issue:
10(12), P. 536 - 536
Published: Dec. 16, 2022
Gold-
and
silver
nanoparticles
(Au
NPs
Ag
NPs)-based
colorimetric
detection
of
specific
analytes
has
attracted
intense
research
interest
is
still
in
great
demand.
The
majority
Au
NPs-
NPs-based
sensory
reports
have
revealed
that,
during
the
analyte
recognition,
dispersed
typically
aggregated
displayed
color
changes
from
wine-red
to
blue/purple
yellow
orange/brown,
respectively.
On
other
hand,
only
a
few
demonstrated
that
underwent
anti-aggregation
presence
certain
analytes,
which
reversed
orange/brown
yellow,
correspondingly.
There
are
some
examples
phenomena
mentioned
vast
number
studies
on
sensors
via
NP
aggregation.
However,
review
targeting
anti-aggregation-enabled
sensing
diverse
not
yet
available.
In
this
review,
anti-aggregation-facilitated
metal
ions,
anions,
bio-analytes,
pesticides,
herbicides
delivered
with
detailed
underlying
mechanisms.
Moreover,
probe
design,
requirement,
merits,
limitations,
future
scope
discussed.
Advances in Sample Preparation,
Journal Year:
2023,
Volume and Issue:
8, P. 100095 - 100095
Published: Sept. 19, 2023
Green
Analytical
Chemistry
(GAC)
principles
have
influenced
the
development
of
analytical
methods
with
minimal
sample
handling
and
operations,
in
contrast
to
conventional
techniques,
which
are
often
laborious
time-consuming.
Since
introduction
microextraction
techniques
1990s,
various
approaches,
configurations,
sorptive
phases
been
proposed
replace
Solid
Phase
Extraction
(SPE)
Liquid-Liquid
(LLE),
covering
a
wide
range
matrices
analytes,
focused
on
chromatography
mass
spectrometry
instrumentation.
The
main
features
simplicity,
low
solvent
consumption,
minimum
residue
generation.
demand
for
fast
results
large
number
samples,
along
advances
instrumentation,
led
coupling
automation
and/or
technologies
multiple
extractions
at
same
time,
known
as
parallel
extractions.
As
result
its
popularity
medical
pharmaceutical
sciences,
96-well
plate
has
successfully
adapted
Microextraction
(SPME)
Liquid
(LPME),
significantly
reducing
time
required
process
samples.
This
review
presents
some
basic
it
contextualizes
compares
published
period
2018
early
2023
context
high-throughput
analyses.
SLAS TECHNOLOGY,
Journal Year:
2024,
Volume and Issue:
unknown, P. 100199 - 100199
Published: Oct. 1, 2024
An
approach
is
described
for
high-throughput
quality
assessment
of
drug
candidate
libraries
using
acoustic
ejection
high-resolution
mass
spectrometry
(AEMS).
Sample
introduction
from
1536-well
plates
demonstrated
this
application
2.5
nL
acoustically
dispensed
sample
droplets
into
an
Open
Port
Interface
(OPI)
with
pneumatically
assisted
electrospray
ionization
at
a
rate
one
second
per
sample.
Both
positive
and
negative
are
shown
to
be
essential
extend
the
compound
coverage
protease
inhibitor-focused
library.
Specialized
software
efficiently
interpreting
data
in
format
presented.
A
new
method
quantifying
concentration
components
(HTQuant)
proposed
that
neither
requires
adding
internal
standard
each
well
nor
further
encumbers
workflow.
This
quantitation
highly
reproducible
peak
areas,
which
consistent
within
4.4%
CV
plate
analysis.
troubleshooting
workflow
based
on
background
ion
current
signal
also
The
AEMS
compared
industry
LC/PDA/ELSD/MS
shows
similar
but
180-fold
greater
throughput.
Despite
same
process,
both
methods
confirmed
presence
small
percentage
compounds
wells
other
did
not.
relatively
small,
focused
library
larger,
more
chemically
diverse
indicate
can
generally
applied
beyond
single
case
study.
capability
particularly
timely
considering
growing
implementation
artificial
intelligence
strategies
require
input
large
amounts
high-quality
formulate
predictions
relevant
discovery
process.
molecular
structures
872-compound
analyzed
here
included
begin
process
correlating
efficiency
parameters
as
initial
step
direction.
Food Research International,
Journal Year:
2025,
Volume and Issue:
208, P. 116173 - 116173
Published: March 14, 2025
Diet
is
one
of
the
main
drivers
non-communicable
chronic
diseases
(NCD).
Modifying
food
supply
may
be
an
attractive
strategy
for
promoting
health
and
reducing
NCD
risk.
The
intentional
modification,
processing,
enrichment,
or
fortification
foods
to
produce
"functional
foods"
currently
varies
according
legal
definitions
existing
regulatory
frameworks,
initially
intended
function,
production
methods.
This
review
critically
appraises
concepts
applied
functional
foods,
proposing
a
new
concept
"functionalized
foods".
conceptual
difference
between
two
categories
that
term
used
products
validated
human
through
controlled
trials,
while
obtained
enrichment
(bio)fortification
lack
such
validation,
yet.
Consequently,
aims
establish
framework
better
understanding
range
products,
enhancing
communication,
more
accurate
interpretation
landscape.
