Organic Process Research & Development,
Journal Year:
2023,
Volume and Issue:
27(11), P. 2082 - 2090
Published: Oct. 24, 2023
High-throughput
experimentation
(HTE)
is
an
important
tool
in
pharmaceutical
process
research
and
development.
However,
most
of
the
current
HTE
workflows
do
not
monitor
reaction
progress
and,
therefore,
provide
no
information
on
kinetic
regimes
(induction,
deactivation,
etc.).
Here,
we
describe
development
a
parallel
monitoring
technique
for
micromole-scale
organic
reactions
using
near-infrared
spectroscopy
multivariate
semi-NMF
analysis
(Non-negative
Matrix
Factorization).
This
workflow
produces
qualitative
profiles
or
semiquantitative
concentration
without
need
time-consuming
calibration.
Advantageously,
simultaneous
improved
confidence
black
box
allowed
direct
comparison
predicted
measured
final
compositions.
Two
test
were
successfully
monitored
our
new
approach.
Coincidentally,
study
led
to
identification
ketone
transfer
hydrogenation
catalyst.
Finally,
initial
rate
kinetics
VTNA
(Variable
Time
Normalization
Analysis)
experiments
performed
technique.
Analytical Science Advances,
Journal Year:
2021,
Volume and Issue:
2(3-4), P. 109 - 127
Published: Jan. 28, 2021
Abstract
High
throughput
experimentation
is
a
growing
and
evolving
field
that
allows
to
execute
dozens
several
thousands
of
experiments
per
day
with
relatively
limited
resources.
Through
miniaturization,
typically
high
degree
automation
the
use
digital
data
tools,
many
parallel
reactions
or
at
time
can
be
run
in
such
workflows.
also
requires
fast
analytical
techniques
capable
generating
critically
important
line
increased
rate
experimentation.
As
traditional
usually
do
not
deliver
speed
required,
some
unique
approaches
are
required
enable
workflows
function
as
designed.
This
review
covers
recent
developments
(2019‐2020)
this
was
intended
give
comprehensive
overview
current
“state‐of‐the‐art.”
Expert Opinion on Drug Discovery,
Journal Year:
2022,
Volume and Issue:
17(7), P. 775 - 787
Published: May 28, 2022
Acoustic
ejection
mass
spectrometry
(AEMS)
is
an
electrospray
ionization-mass
(ESI-MS)
based
analytical
platform
that
provides
high
throughput
and
data
quality.
It
has
been
applied
in
numerous
drug
discovery
workflows,
such
as
high-throughput
screening
(HTS),
absorption,
distribution,
metabolism,
excretion
(ADME)
profiling,
pharmacokinetics
(PK)
analysis,
compound
quality
control
(QC),
the
readout
of
medical
chemistry
samples.This
paper
introduces
working
principle
AEMS
technology.
The
performance,
system
tuning
method
development
representative
applications
on
assays
are
introduced.The
fast
sample
speed,
reproducibility,
wide
coverage,
minimum
carryover,
tolerance
to
complex
matrices
have
demonstrated
its
advantages
over
other
technologies
this
field,
with
broad
applicability
a
diverse
range
workflows.
However,
current
still
challenges
for
some
due
having
less
sensitivity
compared
liquid
chromatography-mass
(LC-MS),
lack
chromatographic
separation
isomeric
interferences.
Despite
remaining
hurdles,
becoming
attractive
discovery.
Additional
developments
would
enable
further
adoption
future.
Chemosensors,
Journal Year:
2022,
Volume and Issue:
10(12), P. 536 - 536
Published: Dec. 16, 2022
Gold-
and
silver
nanoparticles
(Au
NPs
Ag
NPs)-based
colorimetric
detection
of
specific
analytes
has
attracted
intense
research
interest
is
still
in
great
demand.
The
majority
Au
NPs-
NPs-based
sensory
reports
have
revealed
that,
during
the
analyte
recognition,
dispersed
typically
aggregated
displayed
color
changes
from
wine-red
to
blue/purple
yellow
orange/brown,
respectively.
On
other
hand,
only
a
few
demonstrated
that
underwent
anti-aggregation
presence
certain
analytes,
which
reversed
orange/brown
yellow,
correspondingly.
There
are
some
examples
phenomena
mentioned
vast
number
studies
on
sensors
via
NP
aggregation.
However,
review
targeting
anti-aggregation-enabled
sensing
diverse
not
yet
available.
In
this
review,
anti-aggregation-facilitated
metal
ions,
anions,
bio-analytes,
pesticides,
herbicides
delivered
with
detailed
underlying
mechanisms.
Moreover,
probe
design,
requirement,
merits,
limitations,
future
scope
discussed.
Advances in Sample Preparation,
Journal Year:
2023,
Volume and Issue:
8, P. 100095 - 100095
Published: Sept. 19, 2023
Green
Analytical
Chemistry
(GAC)
principles
have
influenced
the
development
of
analytical
methods
with
minimal
sample
handling
and
operations,
in
contrast
to
conventional
techniques,
which
are
often
laborious
time-consuming.
Since
introduction
microextraction
techniques
1990s,
various
approaches,
configurations,
sorptive
phases
been
proposed
replace
Solid
Phase
Extraction
(SPE)
Liquid-Liquid
(LLE),
covering
a
wide
range
matrices
analytes,
focused
on
chromatography
mass
spectrometry
instrumentation.
The
main
features
simplicity,
low
solvent
consumption,
minimum
residue
generation.
demand
for
fast
results
large
number
samples,
along
advances
instrumentation,
led
coupling
automation
and/or
technologies
multiple
extractions
at
same
time,
known
as
parallel
extractions.
As
result
its
popularity
medical
pharmaceutical
sciences,
96-well
plate
has
successfully
adapted
Microextraction
(SPME)
Liquid
(LPME),
significantly
reducing
time
required
process
samples.
This
review
presents
some
basic
it
contextualizes
compares
published
period
2018
early
2023
context
high-throughput
analyses.
Food Research International,
Journal Year:
2025,
Volume and Issue:
208, P. 116173 - 116173
Published: March 14, 2025
Diet
is
one
of
the
main
drivers
non-communicable
chronic
diseases
(NCD).
Modifying
food
supply
may
be
an
attractive
strategy
for
promoting
health
and
reducing
NCD
risk.
The
intentional
modification,
processing,
enrichment,
or
fortification
foods
to
produce
"functional
foods"
currently
varies
according
legal
definitions
existing
regulatory
frameworks,
initially
intended
function,
production
methods.
This
review
critically
appraises
concepts
applied
functional
foods,
proposing
a
new
concept
"functionalized
foods".
conceptual
difference
between
two
categories
that
term
used
products
validated
human
through
controlled
trials,
while
obtained
enrichment
(bio)fortification
lack
such
validation,
yet.
Consequently,
aims
establish
framework
better
understanding
range
products,
enhancing
communication,
more
accurate
interpretation
landscape.
Chemical Society Reviews,
Journal Year:
2025,
Volume and Issue:
unknown
Published: Jan. 1, 2025
We
offer
ten
diverse
perspectives
exploring
the
transformative
potential
of
artificial
intelligence
(AI)
in
chemistry,
highlighting
many
challenges
we
face,
and
offering
strategies
to
address
them.
