Annual Reviews 2020: Recent advances in analytical sciences DOI Open Access
Sebastiaan Eeltink

Analytical Science Advances, Journal Year: 2021, Volume and Issue: 2(3-4), P. 81 - 83

Published: April 1, 2021

This issue of Analytical Science Advances includes review papers written by authorities in the field, covering a wide range topics field analytical sciences. Authors were asked to provide critical discussing state-of-the-art their and highlight key developments applications literature published 2020. These reviews are ideally suited for those who want rapid overview latest advances particular learn about emerging applications. Mass spectrometry (MS) is an immensely important technology that still rapidly develops continues find new application areas. In on rise single-cell proteomics, Ctortecka Mechtler discuss current MS-based workflows. particular, aspects sample preparation when working with minute amounts samples discussed, possibilities separation science highlighted, MS quantification strategies including data postprocessing discussed. An capabilities high-resolution its applicability pharmaceutical analysis provided Géhin Holman. Rankin-Turner Heaney technological ambient ionization paper biomedical sciences, forensics security, food environment, chemical synthesis. The Hoffmann group summarizes imaging, focus approaches tissue-based imaging. Several covered science. De Vos et al. summarize UHPLC multi-dimensional LC instrument development recent Franchina reports instrumental comprehensive two-dimensional gas chromatography (GC × GC), hyphenation novel upstream or downstream processes. Major applied fields such as energy, fuel, foodstuff, plant, biological, environmental also covered. low molecular weight polar ionic components using ion (IC) coupled summarized Bruggink Jensen. Further IC hyphenated inductively plasma mass spectrometric detection reviewed. Muza described designing fabricating bioconjugated self-assembled polymer structures characterization flow fractionation. latter technique utilizes fluid dynamics external force effective separations at steady-state conditions within solvent filled channel. Finally, Eeltink reviewed organic polymer-based monolithic stationary phases. Other included this high-throughput experimentation (HTE), volatile flavor fragrance compounds, trends artificial intelligence, machine learning, chemometrics data. HTE growing evolving Vervoort considers throughput chromatographic spectroscopic techniques, well manipulation. compounds essential characterizing samples, oils, cosmetics. Louw techniques most frequently used 2020, which comprises assisted evaporation extraction, GC mobility spectrometry, electronic senses. Houhou Bocklitz intelligence based methods chemometrics, deep learning respect, inverse modeling, preprocessing methods, modeling spectra image various measurement allowing translate measurements can be full extent. Recently, launched "Art science" initiative, where we showcase artwork linked scientific publication.1, 2 For issue, I have approached Calissa Seelen from Caligrafix Productions her create artist impression different presented issue. obtained Bachelor Law Netherlands Master Sociology Belgium. She developed passion analyzing researching social inequality combines law sociology. After studies she worked European Union Agency Fundamental Rights Vienna (Austria). There experienced first-hand all amazing, life-changing, international research prestigious institute conducted did not reach common people EU. moving back Belgium, started Productions. Among others, creates digital illustrations, logos, layouts sole purpose improving communication between sender message receiver. Research findings extremely tool change world live today. One finding result impact many (daily) lives, without them even knowing how concept became reality. Figure 1 shows created Calissa. reasoning behind design explained illustrator: main idea me was illustration contains essence general subject journal, thematic areas specific operate. Through art image, wanted show humans interconnected through our interests, findings. state interconnectedness shown background image. It networking structure theory six degrees first researched Stanley Milgram his Small World Experiment,3 later referred groundwork theory. psychology widely other hypothesizes any person connected chain acquaintances has no more than five intermediaries average. represents need interdisciplinary collaboration researchers worldwide. dotted wave toward lighter area upper right corner efforts get out "dark" "unknowing" finally understanding, unity, equality among each other. Lastly, there molecules three-dimensional background, interfacing network structure, again small things study them. foreground every atom highlights special will explain meaning clockwise manner. situated top molecule Mechtler.4 simplified version human cell highlighting hunt proteome single modern proteomics used. literally light dark, target hunted decades now comes reach. second correlated Heaney,5 Holman,6 group.7 time-of-flight analysis, drifting vacuum detector. Upon detection, spectrum compound interest generated red. next showcases Louw.8 depicts diffuse air. shape strokes peaks up during in, example, GC. tinner red band string aromatic aiming discover. fourth inspired binary codes demonstrate following paper: Trends Bocklitz.9 fifth al.10 capillary column placed center considered heart analysis. Furthermore, it over course several core apparently changed lot (i.e., columns look exactly same) but so powerful definitely deserves highlighted. last peak pattern needs resolved al.11 three "overlapping" chromatograms information multiple dimensions required information. As whole, work these experts completes picture makes part illustration. Without innovations, fundamental knowledge chemistry life sciences could would lose value. By symbolizing unity advances, stress once importance multidisciplinary alliances, future discoveries. been great pleasure complete like thank contributors valuable time write excellent reviews. Clearly, progress being made direct society. am looking forward follow-up 2022 may include themes insights topics.

Language: Английский

Applications of ambient ionization mass spectrometry in 2022: An annual review DOI Open Access
Stephanie Rankin‐Turner, Patrick Sears, Liam M. Heaney

et al.

Analytical Science Advances, Journal Year: 2023, Volume and Issue: 4(5-6), P. 133 - 153

Published: April 26, 2023

The development of ambient ionization mass spectrometry (AIMS) has transformed analytical science, providing the means performing rapid analysis samples in their native state, both and out laboratory. capacity to eliminate sample preparation pre-MS separation techniques, leading true real-time analysis, led AIMS naturally gaining a broad interest across scientific community. Since introduction first techniques mid-2000s, field exploded with dozens novel ion sources, an array intriguing applications, evident growing diverse areas study. As continues surge forward each year, are increasingly becoming commonplace laboratories around world. This annual review provides overview applications throughout 2022, specific focus on some major fields research, including forensic disease diagnostics, pharmaceuticals food sciences. New methods introduced, demonstrating unwavering drive community further advance this exciting push boundaries what chemistry can achieve.

Language: Английский

Citations

28

Integrating ambient ionization with miniature mass spectrometry to advance green analytical chemistry: an overview DOI Creative Commons
Yufeng Guo, Yuncheng Ge,

Lei Yin

et al.

Green Analytical Chemistry, Journal Year: 2025, Volume and Issue: unknown, P. 100257 - 100257

Published: March 1, 2025

Language: Английский

Citations

1

Advancements in Ambient Ionisation Mass Spectrometry in 2024: An Annual Review DOI Open Access

Alisha Henderson,

Liam M. Heaney, Stephanie Rankin‐Turner

et al.

Analytical Science Advances, Journal Year: 2025, Volume and Issue: 6(1)

Published: March 22, 2025

ABSTRACT The introduction of ambient ionisation mass spectrometry (AIMS) is among the most important developments in analytical chemistry recent years. Enabling direct analysis samples their native state with neither sample preparation nor chromatographic separation provides chemical characterisation a matter seconds. Since its inception early 2000s, field has continued to expand and develop, pushing boundaries finding utility across broad areas scientific research. This annual review an overview key applications AIMS throughout 2024. novel ion sources, development existing techniques for enhanced performance, diverse forensic science, food chemistry, disease detection more highlight expanding versatility widespread adoption globe.

Language: Английский

Citations

1

Ambient ionisation mass spectrometry for drug and toxin analysis: A review of the recent literature DOI Creative Commons

Alisha Henderson,

Liam M. Heaney, Stephanie Rankin‐Turner

et al.

Drug Testing and Analysis, Journal Year: 2024, Volume and Issue: 16(11), P. 1323 - 1344

Published: Feb. 7, 2024

Abstract Ambient ionisation mass spectrometry (AIMS) is a form of whereby analyte occurs outside vacuum source under ambient conditions. This enables the direct analysis samples in their native state, with little or no sample preparation and without chromatographic separation. The removal these steps facilitates much faster analytical process, enabling within minutes if not seconds. Consequently, AIMS has gained rapid popularity across diverse range applications, particular drugs toxins. Numerous fields rely upon for detection identification drugs, including clinical diagnostics, forensic chemistry, food safety. However, all are hindered by time‐consuming laboratory‐confined nature traditional techniques. As such, potential to resolve challenges resulted growing interest drug toxin analysis. Since early 2000s, science, diagnostic testing, anti‐doping, pharmaceuticals, environmental safety have seen marked increase foreshadowing new future testing. In this review, some most promising techniques will be discussed, alongside different applications published over 5‐year period, provide summary recent research activity

Language: Английский

Citations

7

Applications of ambient ionization mass spectrometry in 2021: An annual review DOI
Stephanie Rankin‐Turner, James C. Reynolds, Matthew A. Turner

et al.

Analytical Science Advances, Journal Year: 2022, Volume and Issue: 3(3-4), P. 67 - 89

Published: March 20, 2022

Ambient ionization mass spectrometry (AIMS) has revolutionized the field of analytical chemistry, enabling rapid, direct analysis samples in their native state. Since inception AIMS almost 20 years ago, community driven further development this suite techniques, motivated by plentiful advantages offered addition to traditional spectrometry. Workflows can be simplified through elimination sample preparation, times significantly reduced and remote from laboratory space become a real possibility. As such, interest rapidly spread communities worldwide, techniques are increasingly being integrated with standard operations. This annual review covers applications throughout 2021, specific focus on number key fields research including disease diagnostics, forensics security, food safety testing environmental sciences. While some new introduced, is shifting novel toward efforts improve existing particularly terms reproducibility, quantification ease-of-use.

Language: Английский

Citations

25

Lipidomic-Based Approach to 10 s Classification of Major Pediatric Brain Cancer Types with Picosecond Infrared Laser Mass Spectrometry DOI Creative Commons
Michael Woolman, Taira Kiyota,

Siham A. Belgadi

et al.

Analytical Chemistry, Journal Year: 2024, Volume and Issue: unknown

Published: Jan. 8, 2024

Picosecond infrared laser mass spectrometry (PIRL-MS) is shown, through a retrospective patient tissue study, to differentiate medulloblastoma cancers from pilocytic astrocytoma and two molecular subtypes of ependymoma (PF-EPN-A, ST-EPN-RELA) using laser-extracted lipids profiled with PIRL-MS in 10 s sampling analysis time. The average sensitivity specificity values for this classification, taking genomic profiling data as standard, were 96.41 99.54%, classification used many features resolvable spectra. Data liquid chromatography coupled tandem high-resolution (LC-MS/MS) further allowed us reduce the feature list only 18 metabolic lipid markers most strongly involved classification. identified 'metabolite array' was comprised variety phosphatidic fatty acids, ceramides, phosphatidylcholine/ethanolamine could mediate above-mentioned 94.39 98.78%, respectively, at 95% confidence prediction probability threshold. Therefore, rapid accurate pathology select pediatric brain cancer types known biomarkers can now be available neurosurgeon. Based on mining 'survival' versus 'extent-of-resection' data, we that may benefit actionable feedback. In such cases, aggressiveness surgical resection optimized manner expected patient's overall or progression-free survival. promising tool drive personalized decision-making operating theater.

Language: Английский

Citations

5

An expanded framework for Swab Touch Spray-Mass Spectrometry towards the detection of allergenic protein residues on food preparation surfaces DOI Creative Commons
Lorenzo Toma, Maurizio Piergiovanni, Silvia Gentili

et al.

Analytica Chimica Acta, Journal Year: 2025, Volume and Issue: 1349, P. 343818 - 343818

Published: Feb. 19, 2025

Language: Английский

Citations

0

RapidMass: A Graphical Data Processing Application for Automated Species Authentication in High-Throughput Mass Spectrometry DOI
Chun-Xiang Liu,

Qian Meng,

Yun Li

et al.

Analytical Chemistry, Journal Year: 2025, Volume and Issue: unknown

Published: April 11, 2025

High-throughput mass spectrometry (HT-MS) facilitates rapid, large-scale data acquisition, providing a fast and efficient solution for various analytical challenges. However, the increasing volume of generated by MS requires automation easy-to-use processing tools. Currently, there is no freely available software that compatible with most instruments species authentication or classification. Here, we introduce RapidMass, cutting-edge platform designed to automate handling, evaluation, presentation, management HT-MS identification. Key features include streamlined workflow spectra from (e.g., DI-MS, ASAP-MS, DART-MS), three specialized algorithms scoring unknown samples, peak annotation review, visualization MS1 MS2 spectra, an expandable personal database customized management. Performance validation conducted on nine sets covering diverse sample compositions, instrument types, suppliers, resolutions, acquisition modes, demonstrated RapidMass's excellent performance, times 12 20 s per accuracies ranging 97% 100% easily confused plants. With its user-friendly interface, RapidMass empowers users create manage personalized databases, presenting significant prospects broad applications across fields.

Language: Английский

Citations

0

Mass spectrometry for neurosurgery: Intraoperative support in decision‐making DOI
Stanislav I. Pekov, Denis S. Bormotov,

С. И. Бочарова

et al.

Mass Spectrometry Reviews, Journal Year: 2024, Volume and Issue: unknown

Published: April 4, 2024

Abstract Ambient ionization mass spectrometry was proved to be a powerful tool for oncological surgery. Still, it remains translational technique on the way from laboratory clinic. Brain surgery is most sensitive resection accuracy field since balance between completeness of and minimization nerve fiber damage determines patient outcome quality life. In this review, we summarize efforts made develop various intraoperative support techniques neurosurgery discuss difficulties arising clinical implementation spectrometry‐guided brain

Language: Английский

Citations

3

Identification of MDA in seized ecstasy-like samples using atmospheric solids analysis probe mass spectrometry and machine learning DOI

Rafael Dutra Soares,

Marcos Paulo Thomé,

Danielle Kochenborger John

et al.

Microchemical Journal, Journal Year: 2024, Volume and Issue: 205, P. 111287 - 111287

Published: July 24, 2024

Language: Английский

Citations

3