Cerebral salt wasting syndrome as a probable cause of postoperative polyuria in patients with supratentorial Non-midline tumors: A prospective observational study with targeted and quantitative metabolomic approach

Neurosurgical Review, Journal Year: 2025, Volume and Issue: 48(1)

Published: Feb. 28, 2025

Polyuria, or excessive fluid loss through the kidneys, is a common issue in neurocritical patients, often resulting from conditions such as volume overload, osmotic diuretics, central diabetes insipidus (CDI), cerebral salt wasting syndrome (CSWS). Notably, specific cause of postoperative polyuria within 24 h patients with tumors located supratentorial non-midline region remains poorly understood. To address this gap, we conducted prospective observational study 30 and found that eight (26.7%) experienced polyuria. Binary logistic regression analysis clinical data ruled out diuretics underlying causes polyuria, suggested very subtle association between tumor size (OR = 1.030; p 0.041). A significant decrease serum sodium levels group (p 0.005) pointed towards CSWS potential mechanism. Differentiating CDI CSWS, both involving neuroendocrine hormone dysregulation, challenging due to lack efficient tests. overcome this, developed novel liquid chromatography-tandem mass spectrometry (LC-MS)-based targeted quantitative method measure seven hormones, including antidiuretic (ADH) related six natriuretic peptides associated CSWS. Elevated atrial peptide (ANP), brain (BNP), C-type (CNP), ADH were observed group. Univariate identified ANP, BNP, significantly at threshold < 0.1. Later, multivariate further revealed elevated BNP an independent risk factor for 9111.901; 0.022). These findings suggest may be primary tumors, evidenced by concomitant increase peptides, particularly BNP.

Language: Английский

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Uncovering the molecular mechanisms behind Alzheimer’s and Parkinson’s disease through multi-omics: an interview with Bruno A. Benitez

BioTechniques, Journal Year: 2025, Volume and Issue: unknown, P. 1 - 4

Published: Jan. 31, 2025

Keywords: GenomicsNeurodegenerative diseasesMulti-omicsProteomicstranscriptomicsAlzheimer'sParkinson's

Language: Английский

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Metabolomics Approaches in Toxicology

Elsevier eBooks, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 1, 2025

Language: Английский

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Recent Developments in Single-Cell Metabolomics by Mass Spectrometry─A Perspective

Journal of Proteome Research, Journal Year: 2024, Volume and Issue: unknown

Published: Oct. 22, 2024

Recent advancements in single-cell (sc) resolution analyses, particularly sc transcriptomics and proteomics, have revolutionized our ability to probe understand cellular heterogeneity. The study of metabolism through small molecules, metabolomics, provides an additional level information otherwise unattainable by or proteomics shedding light on the metabolic pathways that translate gene expression into functional outcomes. Metabolic heterogeneity, critical health disease, impacts developmental outcomes, disease progression, treatment responses. However, dedicated approaches probing metabolome not reached maturity other omics technologies. Over past decade, innovations metabolomics addressed some practical limitations, including cell isolation, signal sensitivity, throughput. To fully exploit their potential biological research, however, remaining challenges must be thoroughly addressed. Additionally, integrating with orthogonal techniques will required validate relevant results gain systems-level understanding. This perspective offers a broad-stroke overview recent mass spectrometry (MS)-based advancements, focusing ongoing from biologist's viewpoint, aimed at addressing pertinent innovative questions. we emphasize use showcase systems these sophisticated methodologies are apt explore.

Language: Английский

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An Economically Viable Stable lsotope-Enhanced Multiple Reaction Monitoring Method for Total Fatty Acid Analysis in a Mouse odel of Non-Alcoholic Fatty Liver Disease

Journal of Chromatography A, Journal Year: 2024, Volume and Issue: 1736, P. 465406 - 465406

Published: Sept. 30, 2024

Language: Английский

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Metabolite Annotation through Stable Isotope Labeling

TrAC Trends in Analytical Chemistry, Journal Year: 2024, Volume and Issue: 181, P. 118037 - 118037

Published: Nov. 7, 2024

Language: Английский

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