Biosensors,
Journal Year:
2022,
Volume and Issue:
12(11), P. 984 - 984
Published: Nov. 7, 2022
Rapid
and
cost-effective
diagnostic
tests
for
severe
acute
respiratory
syndrome
coronavirus
2
(SARS-CoV-2)
are
a
critical
valuable
weapon
the
disease
2019
(COVID-19)
pandemic
response.
SARS-CoV-2
invasion
is
primarily
mediated
by
human
angiotensin-converting
enzyme
(hACE2).
Recent
developments
in
ACE2-based
detection
modalities
accentuate
potential
of
this
natural
host-virus
interaction
developing
point-of-care
(POC)
COVID-19
systems.
Although
research
on
harnessing
ACE2
its
infancy,
some
interesting
biosensing
devices
have
been
developed,
showing
commercial
viability
intriguing
new
approach.
The
exquisite
performance
reported
biosensors
provides
opportunities
researchers
to
develop
rapid
tools
suitable
virus
at
points
entry,
workplaces,
or
congregate
scenarios
order
effectively
implement
control
management
plans.
However,
be
considered
as
an
emerging
approach,
rationale
needs
critically
comprehensively
surveyed
discussed.
Herein,
we
review
recent
status
methods,
signal
transduction
principles
development
trend
future.
We
discuss
challenges
ACE2-biosensors
delineate
prospects
their
use,
along
with
recommended
solutions
suggestions.
Angewandte Chemie,
Journal Year:
2022,
Volume and Issue:
134(50)
Published: Sept. 30, 2022
Abstract
Nucleic
acids
are
remarkable
molecules.
In
addition
to
Watson–Crick
base
pairing,
the
different
structural
motifs
of
these
molecules
can
bind
non‐nucleic
acid
targets
or
catalyze
chemical
reactions.
Additionally,
nucleic
easily
modified
with
functional
groups.
These
properties
make
acids,
particularly
DNA,
ideally
suited
for
use
in
electrochemical
biosensors,
both
as
biorecognition
elements
and
redox
reporter
probes.
this
Minireview,
we
will
review
historical
evolution
probes
biosensors.
We
then
specific
examples
nucleic‐acid‐based
biosensors
that
have
been
evaluated
clinical
areas
infectious
disease,
cancer,
cardiovascular
health.
Analysis & Sensing,
Journal Year:
2023,
Volume and Issue:
3(5)
Published: Feb. 2, 2023
Abstract
Many
DNA
aptamers
have
been
reported
to
target
the
spike
protein
(S‐protein)
of
SARS‐CoV‐2.
These
display
different
affinities
or
recognize
epitopes
S‐protein.
We
conducted
a
comparative
study
9
for
binding
several
variants
S‐protein
and
pseudoviruses
using
same
testing
methods,
including
dot‐blot
assays
enzyme‐linked
aptamer
assays,
evaluate
their
affinity
ranking
analytical
utility.
Moreover,
sites
these
on
were
examined
competition
understand
effect
mutations
degree
overlapping
by
aptamers.
ACS Omega,
Journal Year:
2023,
Volume and Issue:
8(36), P. 32877 - 32883
Published: Aug. 31, 2023
The
development
of
a
colorimetric
severe
acute
respiratory
syndrome
coronavirus
2
(SARS-CoV-2)
detection
assay
with
the
WHO
published
ASSURED
criteria
is
reported,
in
which
biosensor
should
have
following
characteristics
(i)
being
affordable
for
low-income
communities,
(ii)
sensitive,
(iii)
specific,
(iv)
user-friendly
to
be
used
by
non-skilled
personnel,
(v)
rapid
and
robust,
(vi)
equipment-free,
(vii)
delivered
end-users
as
simple
easy
use
point-of-care
tool.
Early
viral
infection
prevents
virus
spread
controls
epidemic.
We
herein
report
SARS-COV-2
variants
can
detected
observation
color
on
sensing
cotton
swab
surface.
Using
developed
assay,
it
possible
discriminate
between
various
SARS-CoV-2
LOD
100
ng/mL
within
4
min
including
sample
preconcentration
incubation
step.
results
illustrated
that
mass
produced,
low-reagent
cost,
read-out
visually
field
nonskilled
personnel.
Analytical Chemistry,
Journal Year:
2024,
Volume and Issue:
unknown
Published: Sept. 12, 2024
DNA-templated
reactions
have
found
wide
applications
in
sensing
and
drug
discovery.
However,
this
strategy
has
been
limited
to
the
use
of
nucleic
acids
as
templating
elements
direct
proximity
effect.
Herein,
we
describe
a
versatile
Biosensors,
Journal Year:
2022,
Volume and Issue:
12(11), P. 984 - 984
Published: Nov. 7, 2022
Rapid
and
cost-effective
diagnostic
tests
for
severe
acute
respiratory
syndrome
coronavirus
2
(SARS-CoV-2)
are
a
critical
valuable
weapon
the
disease
2019
(COVID-19)
pandemic
response.
SARS-CoV-2
invasion
is
primarily
mediated
by
human
angiotensin-converting
enzyme
(hACE2).
Recent
developments
in
ACE2-based
detection
modalities
accentuate
potential
of
this
natural
host-virus
interaction
developing
point-of-care
(POC)
COVID-19
systems.
Although
research
on
harnessing
ACE2
its
infancy,
some
interesting
biosensing
devices
have
been
developed,
showing
commercial
viability
intriguing
new
approach.
The
exquisite
performance
reported
biosensors
provides
opportunities
researchers
to
develop
rapid
tools
suitable
virus
at
points
entry,
workplaces,
or
congregate
scenarios
order
effectively
implement
control
management
plans.
However,
be
considered
as
an
emerging
approach,
rationale
needs
critically
comprehensively
surveyed
discussed.
Herein,
we
review
recent
status
methods,
signal
transduction
principles
development
trend
future.
We
discuss
challenges
ACE2-biosensors
delineate
prospects
their
use,
along
with
recommended
solutions
suggestions.
