Fabrication, Preparation, Physicochemical Characterization, and Theoretical Studies of Some Novel Schiff Base Ciprofloxacin Metal Complexes: DNA Interaction and Biomedical Applications
Applied Organometallic Chemistry,
Journal Year:
2024,
Volume and Issue:
38(11)
Published: Aug. 24, 2024
ABSTRACT
Novel
compounds
with
pharmacological
activity
were
synthesized
from
Pd(II),
Fe(III),
Cr(III),
Ni(II),
and
Cu(II)
ions
1‐cyclopropyl‐6‐fluoro‐4‐(2‐hydroxy‐phenylimino)‐7‐piperazin‐1‐yl‐1,4‐dihydro‐quinoline‐3‐carboxylic
acid
(CFAP).
The
ligand's
NH
OH
groups
allowed
it
to
interact
the
metals
as
a
neutral
tridentate.
investigated
novel
described
using
1
H
13
C
NMR
spectra,
FT‐IR
spectrums,
TGA
UV–Vis
(conductance
of
molecules),
CHN‐analysis.
Additionally,
pH
profile
CFAP
complexes
indicated
great
stability,
complexes'
stability
constant
was
discovered
in
solution.
To
extract
important
properties
for
its
complexes,
computational
research
used,
CFAPCu,
CFAPCr,
CFAPNi,
CFAPFe
have
octahedral
geometry,
while
CFAPPd
has
square
planar
geometry.
investigate
molecular
density
functional
theory
calculations
(DFT)
carried
out.
molar
ratio
continuous
fluctuation
data
confirmed
that
(M:L)
(1:1).
In
vitro
tests
conducted
evaluate
Schiff
base's
antimicrobial
action
ligand
metal
chelates
against
fungal
bacterial
infections.
findings
showed
efficacy
is
follows:
When
compared
fluconazol
ofloxacin
reference
medications,
highly
inhibitor
complex.
carcinogenic
potential
Hep‐G2,
MCF‐7,
HCT‐116
cell
lines.
As
medication
vinblastine,
results
once
again
demonstrated
most
active
agent.
Moreover,
demnstrated
strong
reactivity
capturing
free
radicals
when
their
antioxidant
investigated.
Viscosity,
spectral
investigations,
gel
electrophoreses
used
identify
interaction
between
DNA.
Every
examined
compound
shown
be
an
enthusiastic
DNA
binder
by
viscosity
spectrophotometric
titration
investigations.
heightened
hydrophobic
electrostatic
interactions
aromatic
rings
could
cause
this.
Ultimately,
these
regarded
promising
bioactive
substances.
Language: Английский
A comparative study for the efficiency of Pd (II) and Fe (III) complexes as efficient catalysts for synthesis of dihydro‐7H‐5‐thia‐hexaaza‐s‐indacen‐6‐one derivatives supported with DFT approach
Applied Organometallic Chemistry,
Journal Year:
2024,
Volume and Issue:
38(11)
Published: Aug. 4, 2024
Two
novel
complexes
were
synthesized
by
the
reaction
of
benzothiazol‐pyrimidin‐2‐ylidene
ligand
(BTP)
with
Pd
(II)
and
Fe
(III)
ions.
A
variety
various
spectral
analytical
methods
(infrared,
1
H/NMR,
13
C/NMR,
electronic
spectra,
CHN
analyses,
mass
thermogravimetric
analysis,
magnetic
susceptibility)
used
to
characterize
investigated
BTP
its
complexes.
Correlation
experimental
results
density
functional
theory
calculation
proves
that
geometry
BTP‐Fe
complex
is
octahedral,
whereas
BTP‐Pd
square
planner.
The
catalytic
effectiveness
tested
for
three‐component
condensation
process
under
moderate
environmentally
friendly
conditions.
Moreover,
effects
different
Lewis
acid,
basic,
ionic
liquid
catalysts,
as
well
solvent
catalyst
dose
on
investigated.
Both
catalysts
demonstrated
strong
capability
in
carefully
regulated
ideal
circumstances.
Heterogeneous
exhibited
superior
performance
compared
homogeneous
BTP‐Fe.
All
products
obtained
high
TOF
(turnover
frequency)
numbers
presence
these
which
indicate
efficiency
synthesis
dihydro‐7H‐5‐thia‐hexaaza‐s‐indacen‐6‐one
derivatives.
two
catalysts'
recycling
reusability
reactions
also
could
be
reused
up
seven
times
efficiency,
but
(BTP‐Fe)
only
recycled
four
times.
Furthermore,
mechanism
was
suggested
supported
DFT
calculation.
simplicity,
safety,
stability,
use
commercially
available
quick
times,
excellent
yields
make
it
promising
future
industrial
use.
Language: Английский
Synthesis, Structural Determination, DFT Calculation and Biological Evaluation Supported by Molecular Docking Approach of Some New Complexes Incorporating (E)‐N'‐(3,5‐di‐Tert‐Butyl‐2‐Hydroxybenzylidene) Isonicotino Hydrazide Ligand
Applied Organometallic Chemistry,
Journal Year:
2024,
Volume and Issue:
39(1)
Published: Sept. 29, 2024
ABSTRACT
The
synthesis
and
structural
analysis
of
complexes
derived
from
(E)‐N′‐(3,5‐di‐
tert
‐butyl‐2‐hydroxybenzylidene)
isonicotino
hydrazide
(
ITB
ligand)
were
examined
using
multiple
analytical
techniques.
These
techniques
included
TGA,
decomposition
point
determination,
elemental
(CHN),
spectroscopic
(IR,
NMR,
mass
spectrometry)
analysis,
magnetic
susceptibility,
conductivity,
as
well
UV–Vis
spectrum
along
with
theoretical
studies.
Molar
conductance
values
indicated
that
the
Cd
(II),
Co
Cu
Ni
Zn
(II)
are
non‐electrolytes
in
fresh
DMSO
solutions,
ranging
8.5
to
14.35
Ω
−1
cm
2
mol
.
IR
spectra
suggested
which
ligand
coordinates
through
metal
ions
a
tridentate
fashion,
utilizing
(N
&
O)
donor
sites
(CN
CO
CO)
groups
hydroxybenzylidene
moiety.
Analytical
data
solution
complexation,
job's
method
1:1
(metal:ligand)
molar
ratio.
stability
order
was
determined
ITBCo
>
ITBCu
ITBNi
ITBZn
ITBCd,
consistent
constant
(K
f
)
values.
pH
profile
studied
exhibit
upon
wide
scale,
typically
between
(pH
=
4:10).
Magnetic
electronic
spectral
analyses
helped
deduce
coordination
abilities
geometric
structures
complexes.
In
vitro
(antimicrobial
anticancer)
performances
tested
versus
various
(microbial
strains
cancer
cell
lines),
revealing
higher
activity
chelates
assessed
free
ligand.
antioxidant
potential
also
DPPH
assay.
Finally,
molecular
docking
performed
toward
estimate
binding
efficiency
protein
receptors
compounds,
results
aligning
biological
investigations.
Language: Английский
Tailoring of Novel Ru (III) and Cr (III) Salen Complexes as Catalysts for a Sustainable and Green Synthesis of Dihydro‐tetrazolo [1,5‐a] thiazolo [4,5‐d] pyrimidin‐6‐yl morpholine: Experimental and Theoretical Approaches
Applied Organometallic Chemistry,
Journal Year:
2024,
Volume and Issue:
unknown
Published: Nov. 15, 2024
ABSTRACT
Two
novel
Cr
(III)
and
Ru
salen
complexes
based
on
{3,4‐Bis‐[(5‐chloro‐2‐hydroxy‐benzylidene)‐amino]‐phenyl}‐phenyl‐methanone
ligand
(CSAB)
were
synthesized.
The
characterized
using
various
spectral
analytical
methods.
catalytic
performance
of
the
CSAB
was
investigated
via
a
four‐component
condensation
reaction
involving
aromatic
aldehydes,
rhodamine,
morpholine,
5‐aminotetrazole
under
mild,
environmentally
friendly
conditions.
Different
Lewis
acids,
bases,
ionic
liquid
catalysts,
solvents,
catalyst
amounts
assessed
to
optimize
parameters.
Both
systems
demonstrated
robust
activity
strictly
managed
conditions,
with
heterogeneous
CSAB‐Ru
showing
superior
efficacy
compared
homogeneous
CSAB‐Cr
catalyst.
study
confirmed
capabilities
both
evaluated
their
recyclability
reusability.
(CSAB‐Ru)
could
be
reused
seven
times,
whereas
(CSAB‐Cr)
recycled
four
times.
strong
selectivity,
resulting
in
high
product
yields.
provides
insights
into
synthetic
applications
complexes,
highlighting
potential
organic
transformations.
It
emphasizes
ease
use,
safety,
stability,
component
availability,
quick
yields,
making
them
promising
for
future
industrial
applications.
Language: Английский
A robust synthesis, physicochemical characterization, Stability determination and potential biomedical applications of novel Salen complexes supported by theoretical approaches
Journal of Molecular Structure,
Journal Year:
2025,
Volume and Issue:
unknown, P. 142060 - 142060
Published: March 1, 2025
Language: Английский
Fe (III)–porphyrin complex as an efficient and recyclable homogeneous catalyst for the synthesis of pyrano thiazole 6-carbonitrile derivatives in aqueous medium
Inorganic Chemistry Communications,
Journal Year:
2024,
Volume and Issue:
165, P. 112494 - 112494
Published: May 11, 2024
Language: Английский
Mn (III)‐Porphyrin Complex as an Efficient and Recyclable Homogeneous Catalyst for Convenient Synthesis of Thioxo‐4,5‐Dihydro‐3H‐thiazolo Pyrimidin‐2‐One Derivatives in Aqueous Media via a One‐Pot Multicomponent Reaction
Applied Organometallic Chemistry,
Journal Year:
2024,
Volume and Issue:
39(1)
Published: Dec. 15, 2024
ABSTRACT
This
study
successfully
utilized
the
Mn
(III)–porphyrin
complex
(Mn
(PT)Cl)
as
an
efficient
and
recyclable
catalyst
for
a
one‐pot,
three‐component
reaction
involving
aromatic
aldehydes,
2,4‐thiazolidinedione,
thiourea.
The
yielded
thioxo‐4,5‐dihydro‐
3H
‐thiazolo
pyrimidin‐2‐one
derivatives
under
eco‐friendly
conditions.
Elemental
spectral
analyses
confirmed
structures
of
synthesized
compounds,
validating
successful
formation
target
products.
reactions
were
conducted
in
sustainable
environment
using
green
solvent
mixture
H₂O
EtOH.
results
showcased
excellent
catalytic
activity
selectivity
complexes,
resulting
good
yields
desired
research
provides
valuable
insights
into
synthetic
applications
(PT)Cl
emphasizes
potential
such
catalysts
various
organic
transformations.
method's
simplicity,
safety,
commercial
availability,
stability,
rapid
times,
high
indicate
promising
future
industry.
Language: Английский