Gut microbiota contributes to obstructive sleep apnea-induced hypertension by gut-heart axis in mice DOI Creative Commons
Xiaotong Zhang,

Yanran Yin,

Yongjun Chen

et al.

International Immunopharmacology, Journal Year: 2025, Volume and Issue: 155, P. 114667 - 114667

Published: April 16, 2025

The gut microbiome has been closely linked to obstructive sleep apnea (OSA)-associated hypertension (HTN). However, its precise role in the pathogenesis of OSA-induced HTN remains unclear. To clarify causal relationship between dysbiosis and OSA-related HTN, C57BL6J mice were randomly assigned four groups. Each group underwent fecal microbiota transplantation from healthy individuals (control), OSA patients (OSA group), with pre-hypertension (OSA-pHTN or (OSA-HTN group). pro-hypertensive effects verified, composition function compared using 16S rDNA gene sequencing. Additionally, microbiota-related lipopolysaccharide (LPS)/ Toll-like receptor 4 (TLR4)/nuclear factor-kappaB (NF-κB) pathway aortic tissues was investigated. Fecal induced increased systolic blood pressure injury OSA, OSA-pHTN OSA-HTN groups, whereas no significant observed control group. These three groups exhibited impaired intestinal barrier as evidenced by a reduction Akkermansia decreased expression zonula occludens-1 Occludin proteins. In addition, LPS, TLR4 phosphorylated NF-κB tissue immunofluorescence showed upregulation endothelial cells controls. This study demonstrates mediated through gut-derived LPS/TLR4/NF-κB pathway. findings may guide development therapeutic strategies focused on restoring homeostasis.

Language: Английский

The Battle of LPS Clearance in Host Defense vs. Inflammatory Signaling DOI Creative Commons
Pankaj Kumar, Evan A. Schroder, Murugesan V. S. Rajaram

et al.

Cells, Journal Year: 2024, Volume and Issue: 13(18), P. 1590 - 1590

Published: Sept. 21, 2024

Lipopolysaccharide (LPS) in blood circulation causes endotoxemia and is linked to various disease conditions. Current treatments focus on preventing LPS from interacting with its receptor Toll-like 4 (TLR4) reducing inflammation. However, our body has a natural defense mechanism: reticuloendothelial cells the liver rapidly degrade inactivate much of circulating within minutes. But this clearance mechanism not perfect. Excessive that escape cause systemic inflammatory damage through TLR4. Despite importance, role elimination well-studied, especially regarding specific cells, receptors, mechanisms involved. This gap hampers development effective therapies for related diseases. review consolidates current understanding clearance, narrates known explores potential mechanisms, discusses relationship between signaling. It also aims highlight key insights can guide strategies reduce by way bolstering host mechanisms. Ultimately, we seek provide foundation future research could lead innovative approaches enhancing body’s ability clear thereby lower risk endotoxin-related diseases, including sepsis.

Language: Английский

Citations

9
Gut microbiota contributes to obstructive sleep apnea-induced hypertension by gut-heart axis in mice DOI Creative Commons
Xiaotong Zhang,

Yanran Yin,

Yongjun Chen

et al.

International Immunopharmacology, Journal Year: 2025, Volume and Issue: 155, P. 114667 - 114667

Published: April 16, 2025

The gut microbiome has been closely linked to obstructive sleep apnea (OSA)-associated hypertension (HTN). However, its precise role in the pathogenesis of OSA-induced HTN remains unclear. To clarify causal relationship between dysbiosis and OSA-related HTN, C57BL6J mice were randomly assigned four groups. Each group underwent fecal microbiota transplantation from healthy individuals (control), OSA patients (OSA group), with pre-hypertension (OSA-pHTN or (OSA-HTN group). pro-hypertensive effects verified, composition function compared using 16S rDNA gene sequencing. Additionally, microbiota-related lipopolysaccharide (LPS)/ Toll-like receptor 4 (TLR4)/nuclear factor-kappaB (NF-κB) pathway aortic tissues was investigated. Fecal induced increased systolic blood pressure injury OSA, OSA-pHTN OSA-HTN groups, whereas no significant observed control group. These three groups exhibited impaired intestinal barrier as evidenced by a reduction Akkermansia decreased expression zonula occludens-1 Occludin proteins. In addition, LPS, TLR4 phosphorylated NF-κB tissue immunofluorescence showed upregulation endothelial cells controls. This study demonstrates mediated through gut-derived LPS/TLR4/NF-κB pathway. findings may guide development therapeutic strategies focused on restoring homeostasis.

Language: Английский

Citations

0