MiRNA Omics Reveal the Mechanisms of the Dual Effects of Selenium Supplementation on the Development of the Silkworm (Bombyx mori) DOI Open Access

Wen‐Jie Ge,

Fei Hu, Tingting Hong

et al.

International Journal of Molecular Sciences, Journal Year: 2025, Volume and Issue: 26(7), P. 3394 - 3394

Published: April 4, 2025

This study explores the dual effects of selenium (Se) supplementation on silkworm development by analyzing miRNA expression profiles fat bodies in silkworms under different Se concentrations (50 µM and 200 µM). Compared to control, 84 miRNAs displayed levels F_50 group, with 72 up-regulated 12 down-regulated; 152 were differentially expressed F_200 124 28 down-regulated. In target genes mainly enriched Toll Imd signaling pathways, oxidative phosphorylation, ribosome biogenesis eukaryotes; however, eukaryotes, spliceosome group. Based results protein-protein interaction network miRNA-target network, bmo-miR-2a-1-5p bmo-miR-317-3p_L-2R+2 screened as key group respectively. The targeted 10014128 (DREDD), 100862750 (ATF2), 101744000 (Tak1) genes, which pathways. primarily regulated 101738508 (SF3b) 101746688 (Prp19) pathway. Thus, our demonstrated that improved via regulation pathways inhibited it targeting Our data revealed 50 could improve productivity; meanwhile, a treatment toxic effects, leading impaired development.

Language: Английский

MiRNA Omics Reveal the Mechanisms of the Dual Effects of Selenium Supplementation on the Development of the Silkworm (Bombyx mori) DOI Open Access

Wen‐Jie Ge,

Fei Hu, Tingting Hong

et al.

International Journal of Molecular Sciences, Journal Year: 2025, Volume and Issue: 26(7), P. 3394 - 3394

Published: April 4, 2025

This study explores the dual effects of selenium (Se) supplementation on silkworm development by analyzing miRNA expression profiles fat bodies in silkworms under different Se concentrations (50 µM and 200 µM). Compared to control, 84 miRNAs displayed levels F_50 group, with 72 up-regulated 12 down-regulated; 152 were differentially expressed F_200 124 28 down-regulated. In target genes mainly enriched Toll Imd signaling pathways, oxidative phosphorylation, ribosome biogenesis eukaryotes; however, eukaryotes, spliceosome group. Based results protein-protein interaction network miRNA-target network, bmo-miR-2a-1-5p bmo-miR-317-3p_L-2R+2 screened as key group respectively. The targeted 10014128 (DREDD), 100862750 (ATF2), 101744000 (Tak1) genes, which pathways. primarily regulated 101738508 (SF3b) 101746688 (Prp19) pathway. Thus, our demonstrated that improved via regulation pathways inhibited it targeting Our data revealed 50 could improve productivity; meanwhile, a treatment toxic effects, leading impaired development.

Language: Английский

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