Phytotherapy Research,
Journal Year:
2024,
Volume and Issue:
unknown
Published: Oct. 9, 2024
Pulmonary
infections
have
a
profound
influence
on
global
mortality
rates.
Medicinal
plants
offer
promising
approach
to
address
this
challenge,
providing
nontoxic
alternatives
with
higher
levels
of
public
acceptance
and
compliance,
particularly
in
regions
where
access
conventional
medications
or
diagnostic
resources
may
be
limited.
Understanding
the
pathophysiology
viruses
bacteria
enables
researchers
identify
biomarkers
essential
for
triggering
diseases.
This
knowledge
allows
discovery
biological
molecules
capable
either
preventing
alleviating
symptoms
associated
these
infections.
In
review,
medicinal
that
an
effect
COVID-19,
influenza
A,
bacterial
viral
pneumonia,
tuberculosis
are
discussed.
Drug
delivery
has
been
briefly
discussed
as
well.
It
examines
bioactive
constituents
synthesizes
findings
from
vitro,
vivo,
clinical
studies
conducted
over
past
decade.
conclusion,
many
can
used
treat
pulmonary
infections,
but
further
in-depth
needed
most
current
only
at
preliminary
stages.
Extensive
investigation
warranted
fully
elucidate
their
mechanisms
action
optimize
use
practice.
Archiv der Pharmazie,
Journal Year:
2022,
Volume and Issue:
355(10)
Published: June 7, 2022
Abstract
The
severe
acute
respiratory
syndrome
coronavirus‐2
(SARS‐CoV‐2)
infection
is
linked
with
inflammatory
disorders
and
the
development
of
oxidative
stress
in
extreme
cases.
Therefore,
anti‐inflammatory
antioxidant
drugs
may
alleviate
these
complications.
Ginkgo
biloba
L.
folium
extract
(EGb)
a
herbal
medicine
containing
various
active
constituents.
This
review
aims
to
provide
critical
discussion
on
potential
role
EGb
management
coronavirus
disease
2019
(COVID‐19).
antiviral
effect
mediated
by
different
mechanisms,
including
blocking
SARS‐CoV‐2
3‐chymotrypsin‐like
protease
that
provides
trans‐variant
effectiveness.
Moreover,
impedes
pulmonary
through
diminution
neutrophil
elastase
activity,
release
proinflammatory
cytokines,
platelet
aggregation,
thrombosis.
Thus,
can
attenuate
lung
injury
distress
COVID‐19.
In
conclusion,
offers
being
used
as
adjuvant
symptomatic
therapy.
Nanosystems
enabling
targeted
delivery,
personalization,
booster
effects
opportunity
for
use
modern
phytotherapy.
Pharmaceutics,
Journal Year:
2023,
Volume and Issue:
15(5), P. 1562 - 1562
Published: May 22, 2023
Coronavirus
infections
are
neuroinvasive
and
can
provoke
injury
to
the
central
nervous
system
(CNS)
long-term
illness
consequences.
They
may
be
associated
with
inflammatory
processes
due
cellular
oxidative
stress
an
imbalanced
antioxidant
system.
The
ability
of
phytochemicals
anti-inflammatory
activities,
such
as
Ginkgo
biloba,
alleviate
neurological
complications
brain
tissue
damage
has
attracted
strong
ongoing
interest
in
neurotherapeutic
management
long
COVID.
biloba
leaf
extract
(EGb)
contains
several
bioactive
ingredients,
e.g.,
bilobalide,
quercetin,
ginkgolides
A–C,
kaempferol,
isorhamnetin,
luteolin.
have
various
pharmacological
medicinal
effects,
including
memory
cognitive
improvement.
through
its
anti-apoptotic,
antioxidant,
impacts
function
other
conditions
like
those
While
preclinical
research
on
therapies
for
neuroprotection
shown
promising
results,
clinical
translation
remains
slow
challenges
(e.g.,
low
drug
bioavailability,
limited
half-life,
instability,
restricted
delivery
target
tissues,
poor
capacity).
This
review
emphasizes
advantages
nanotherapies
using
nanoparticle
approaches
overcome
these
challenges.
Various
experimental
techniques
shed
light
molecular
mechanisms
underlying
response
help
comprehend
pathophysiology
sequelae
SARS-CoV-2
infection.
To
develop
novel
therapeutic
agents
systems,
methods
mimicking
been
used
lipid
peroxidation
products,
mitochondrial
respiratory
chain
inhibitors,
models
ischemic
damage).
We
hypothesize
beneficial
effects
EGb
COVID-19
symptoms,
evaluated
either
vitro
or
vivo
animal
stress.
Frontiers in Pharmacology,
Journal Year:
2022,
Volume and Issue:
13
Published: Oct. 11, 2022
It
is
an
often-neglected
fact
that
extracts
derived
from
the
very
same
plant
can
differ
significantly
in
their
phytochemical
composition,
and
thus
also
pharmacokinetic
pharmacodynamic
properties
which
are
basis
for
clinical
efficacy
safety.
The
Ginkgo
biloba
L.
[
Ginkgoaceae
]
special
extract
EGb
761
®
one
of
best-studied
world.
In
present
review,
using
as
a
paradigm,
we
describe
insights
how
climate,
harvest
region,
processing
material,
drying
process,
extraction
solvents,
details
subsequent
process
steps
substantially
impact
quality
uniformity
final
extract.
We
highlight
importance
regulating
active
constituent
levels
consistent
reduction
undesired
substances
herbal
extracts.
This
accomplished
by
controlled
production
corresponding
analytical
specifications.
conclusion,
since
have
different
compositions,
results
pharmacological,
toxicological
studies
gained
with
specific
cannot
be
extrapolated
to
other
were
generated
processes.
propose
heterogenous
nature
should
meticulously
considered
when
evaluating
safety
plant-derived
remedies.
Pharmacological Research - Modern Chinese Medicine,
Journal Year:
2023,
Volume and Issue:
9, P. 100331 - 100331
Published: Nov. 27, 2023
Ginkgo
biloba
L.
(Ginkgoaceae),
known
as
a
"living
fossil,"
has
long
history
of
medicinal
use.
Both
its
leaves
and
nuts
have
been
widely
prescribed
for
the
treatment
various
ailments,
including
pulmonary
diseases,
alcohol
abuse,
bladder
inflammation,
heart
lung
dysfunction,
skin
infections.
Currently,
there
are
different
forms
G.
available
in
market,
extracts
isolated
compounds
such
terpenoids,
flavonoids,
bioflavonoids,
organic
acids.
Despite
significant
importance
this
plant,
is
lack
updated
reviews
encompassing
pharmacology
other
relevant
aspects.
Therefore,
objective
review
to
collect
analyze
existing
literature
on
phytochemical,
ethnobotanical,
pharmacological
aspects
biloba.
Electronic
databases
PubMed,
Embase,
Scopus,
Google
Scholar
were
searched
keywords
"Ginkgo
biloba"
or
"ginkgo"
combination
with
"phytochemistry",
"ethnobotany",
"pharmacology",
"nervous
system",
"cardiovascular",
etc.
articles.
There
was
no
language
restriction.
Retrieved
studies
showed
that
from
beneficial
activities
cerebrovascular,
nervous,
cardiovascular,
endocrine,
muscular
skeletal,
renal,
respiratory,
digestive,
immunity
systems.
Numerous
vitro
vivo
conducted
investigate
therapeutic
potential
improvement
diseases.
Additionally,
substantial
body
clinical
research
preparations
compounds.
However,
further
investigations,
particularly
human-controlled
trials,
recommended
determine
efficacy
safety
These
trials
would
provide
more
robust
evidence
regarding
benefits
risks
associated
use
settings.
Immunity Inflammation and Disease,
Journal Year:
2023,
Volume and Issue:
11(4)
Published: April 1, 2023
Coronavirus
disease
2019
(Covid-19)
is
caused
by
a
novel
severe
acute
respiratory
syndrome
coronavirus
virus
type
2
(SARS-CoV-2)
leading
to
the
global
pandemic
worldwide.
Systemic
complications
in
Covid-19
are
mainly
related
direct
SARS-CoV-2
cytopathic
effects,
associated
hyperinflammation,
hypercytokinemia,
and
development
of
cytokine
storm
(CS).
As
well,
developed
due
propagation
oxidative
thrombotic
events
which
may
progress
state
called
(TS),
respectively.
In
addition,
inflammatory
lipid
storms
also
activation
cells
release
bioactive
lipids
correspondingly.
Therefore,
present
narrative
review
aimed
elucidate
interrelated
relationship
between
different
types
mixed
(MS).
conclusion,
infection
induces
various
including
CS,
storm,
TS
storm.
These
not
developing
alone
since
there
close
them.
MS
seems
be
more
appropriate
than
it
develops
intricate
interface
reactive
oxygen
species,
proinflammatory
cytokines,
complement
activation,
coagulation
disorders,
activated
signaling
pathway.
Viruses,
Journal Year:
2024,
Volume and Issue:
16(3), P. 320 - 320
Published: Feb. 20, 2024
In
2020,
severe
acute
respiratory
syndrome
coronavirus-2
(SARS-CoV-2)
challenged
the
world
with
a
global
outbreak
that
led
to
millions
of
deaths
worldwide.
Coronavirus
disease
2019
(COVID-19)
is
symptomatic
manifestation
this
virus,
which
can
range
from
flu-like
symptoms
utter
clinical
complications
and
even
death.
Since
there
was
no
clear
medicine
could
tackle
infection
or
lower
its
minimal
adverse
effects
on
patients’
health,
health
organization
(WHO)
developed
awareness
programs
rate
limit
fast
spread
virus.
Although
vaccines
have
been
as
preventative
tools,
people
still
prefer
going
back
traditional
herbal
medicine,
provides
remarkable
benefits
either
prevent
viral
progression
through
different
mechanistic
pathways
relatively
insignificant
side
effects.
This
comprehensive
review
scientific
evidence
elucidating
effect
10
plants
against
SARS-CoV-2,
paving
way
for
further
studies
reconsider
plant-based
extracts,
rich
in
bioactive
compounds,
into
more
advanced
assessments
order
identify
their
impact
patients
suffering
COVID-19.
Research Journal of Pharmacy and Technology,
Journal Year:
2025,
Volume and Issue:
unknown, P. 393 - 401
Published: Jan. 27, 2025
When
oral
tissues
are
infected
with
viruses,
the
usually
develop
blisters
or
ulcerations.
These
infections
seen
in
dental
settings,
but
because
of
their
low
prevalence
and
difficult
diagnosis,
they
frequently
do
not
receive
much
clinical
attention.
This
page
compiles
data
on
viral
infections'
etiology,
signs,
diagnosis
techniques,
management
plans.
DNA
including
those
belonging
to
families
Herpesviridae,
Papillomaviridae,
Poxviridae,
linked
sores.
Moreover,
cavity
can
be
impacted
by
RNA
viruses
enteroviruses
paramyxoviruses.
Many
antiviral
medications
available
market;
however
might
alter
microbiota
have
unfavorable
side
effects.
Consequently,
natural
phytochemicals
extracted
from
plants
that
historically
been
used
medicine
as
promising
alternatives,
hunt
for
alternatives
products
continues.
Using
keywords,
we
looked
a
variety
literature
this
study
using
PubMed
Google
Scholar
search
engines.
The
first
yielded
280
papers
based
titles,
abstracts,
publication
dates.
There
were
156
unique
articles
left
when
duplicate
items
eliminated.
research
will
examine
most
widely
plant
inhibits
pathogen
development,
decreases
biofilm
plaque
production,
affects
adherence
surfaces,
relieves
symptoms
associated
diseases.
