Comprehensive review of the expanding roles of the carnitine pool in metabolic physiology: beyond fatty acid oxidation

Journal of Translational Medicine, Journal Year: 2025, Volume and Issue: 23(1)

Published: March 14, 2025

Traditionally, the carnitine pool is closely related to fatty acid metabolism. However, with increasing research, pleiotropic effects of have gradually emerged. The purpose this review comprehensively investigate emerging understanding role pool, carnitine/acylcarnitines are not only auxiliaries or metabolites oxidation, but also play more complex and diverse roles, including energy metabolism, mitochondrial homeostasis, epigenetic regulation, regulation inflammation immune system, tumor biology, signal transduction, neuroprotection. This provides an overview network synthesis, transport, shuttle, potential be used as communication molecules, biomarkers therapeutic targets for multiple diseases, profound on intercellular communication, metabolic interactions between organs overall health. summarize multidimensional biological beyond its traditional in oxidation systemic mediated by carnitine/acylcarnitine provide new perspectives pharmacological research treatment innovation strategies prevention a variety diseases.

Language: Английский

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Pioglitazone attenuates tamoxifen-induced liver damage in rats via modulating Keap1/Nrf2/HO-1 and SIRT1/Notch1 signaling pathways: In-vivo investigations, and molecular docking analysis

Molecular Biology Reports, Journal Year: 2023, Volume and Issue: 50(12), P. 10219 - 10233

Published: Nov. 7, 2023

Tamoxifen (TAM) is a chemotherapeutic drug widely utilized to treat breast cancer. On the other hand, it exerts deleterious cellular effects in clinical applications as an antineoplastic agent, such liver damage and cirrhosis. TAM-induced hepatic toxicity mainly attributed oxidative stress inflammation. Pioglitazone (PIO), peroxisome proliferator-activated receptor-gamma (PPAR-γ) agonist, diabetes mellitus type-2. PIO has been reported exert anti-inflammatory antioxidant different tissues. This research assessed impact of against intoxication.Rats received (10 mg/kg) TAM (45 orally for 10 days.TAM increased aspartate aminotransferase (AST) alanine (ALT), triggered several histopathological alterations, NF-κB p65, stress, pro-inflammatory cytokines. protects dysfunction, reduced malondialdehyde (MDA), markers along with improved antioxidants. Moreover, PIO, Bcl-2 expression while reducing Bax caspase-3 levels. In addition, decreased Keap-1, Notch1, Hes-1 upregulated HO-1, Nrf2, SIRT1. Molecular docking showed binding affinity NF-κB, SIRT1.PIO mitigated hepatotoxicity by decreasing apoptosis, inflammation, stress. The protecting ability was accompanied Keap-1 regulating Keap1/Nrf2/HO-1 Sirt1/Notch1 signaling. A schematic diagram illustrating protective effect hepatotoxicity. prevented injury Nrf2/HO-1 SIRT1/Notch1 signaling mitigating apoptosis.

Language: Английский

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Dabigatran attenuates methotrexate-induced hepatotoxicity by regulating coagulation, endothelial dysfunction, and the NF-kB/IL-1β/MCP-1 and TLR4/NLRP3 signaling pathways

Naunyn-Schmiedeberg s Archives of Pharmacology, Journal Year: 2024, Volume and Issue: unknown

Published: Nov. 11, 2024

Language: Английский

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Expression of nicastrin, NICD1, and Hes1 in NCSTN knockout mice: implications for hidradenitis suppurativa, Alzheimer’s, and liver cancer

European journal of medical research, Journal Year: 2024, Volume and Issue: 29(1)

Published: Dec. 24, 2024

Language: Английский

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