Recent Advances in Natural Products Derived from Marine Echinoderms and Endophytic Microbes: Chemical Insights and Therapeutic Potential

Marine Drugs, Journal Year: 2025, Volume and Issue: 23(1), P. 33 - 33

Published: Jan. 10, 2025

Echinoderms, a diverse group of marine invertebrates including starfish, sea urchins, and cucumbers, have been recognized as prolific sources structurally natural products. In the past five years, remarkable progress has made in isolation, structural elucidation, pharmacological assessment these bioactive compounds. These metabolites, polysaccharides, triterpenoids, steroids, peptides, demonstrate potent bioactivities such anticancer, anti-inflammatory, antiviral, antimicrobial effects, providing valuable insights scaffolds for drug discovery. This review highlights diversity biological activities products derived from echinoderms over last with particular focus on their structure–activity relationships therapeutic potential. It also outlines prospects challenges future research, aiming to stimulate further exploration

Language: Английский

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Antioxidant activities of three enzymatic hydrolysates from Stichopus japonicus on HaCaT cells in vitro and zebrafish in vivo

Natural Product Research, Journal Year: 2025, Volume and Issue: unknown, P. 1 - 5

Published: Jan. 31, 2025

To explore the antioxidant activity of enzymatic hydrolysates S. japonicus from Dalian and preliminarily elucidate their mechanisms action both in vitro vivo. Samples were hydrolysed using alcalase, protamex, neutrase. 2,2-diphenyl-1-(2,4,6-trinitrophenyl)hydrazyl (DPPH) 2,2'-azinobis-(3-ethylbenzothiazoline-6-sulfonic acid (ABTS) radical scavenging assays showed that alcalase hydrolysate had highest activity, with IC50 values 4.233 ± 0.067 mg/mL 1.188 0.066 (ABTS). Further cell experiments indicated effectively inhibited intracellular reactive oxygen species (ROS), a fluorescence rate 4.29% 1.98%, modulated antioxidant-related enzymes (superoxide dismutase: SOD, glutathione peroxidase: GSH-PX, malondialdehyde: MDA). The obtained optimal was analysed by LC-MS/MS. zebrafish (AAPH: 100%) decreased to 29.24% 1.10% (acridine orange: AO) 56.71% 0.02% no observed embryonic toxicity. This study provides foundation for development natural antioxidants.

Language: Английский

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Peptides from Dalian Stichopus japonicus: Antioxidant Activity and Melanogenesis Inhibition In Vitro Cell Models and In Vivo Zebrafish Models Guided by Molecular Docking Screening

Marine Biotechnology, Journal Year: 2025, Volume and Issue: 27(2)

Published: March 5, 2025

Language: Английский

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Research on the Mixed Culture of Northern <i>Apostichopus </i><i>japonicus</i> and <i>Strongylocentrotus </i><i>intermedius</i> in Ponds

Advances in Marine Sciences, Journal Year: 2025, Volume and Issue: 12(01), P. 70 - 75

Published: Jan. 1, 2025

Language: Английский

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Tube feet regulate aggregation behavior of the sea cucumber Apostichopus japonicus

Aquaculture International, Journal Year: 2025, Volume and Issue: 33(3)

Published: March 19, 2025

Language: Английский

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Interaction mechanisms of sea cucumber proteins with flavor compounds: Adsorption behavior, dynamic equilibrium and structural changes

Food Chemistry, Journal Year: 2025, Volume and Issue: unknown, P. 144767 - 144767

Published: May 1, 2025

Language: Английский

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Matrikines of Sea Cucumbers: Structure, Biological Activity and Mechanisms of Action

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(22), P. 12068 - 12068

Published: Nov. 10, 2024

Matrikines (MKs), the products of enzymatic fragmentation various extracellular matrix (ECM) proteins, regulate cellular activity by interacting with specific receptors. MKs affect cell growth, proliferation, and migration, can induce apoptosis autophagy, are also effectively used in biomedicine functional nutrition. Recently, there has been great interest structural features biological from sources. This review summarized analyzed results modern research on sea cucumbers, primarily trepang (MKT). Particular attention is paid to analysis existing knowledge antioxidant, anti-inflammatory adaptogenic activities these possible mechanisms their protective action.

Language: Английский

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Sea cucumber saponins reduce blood alcohol and acetaldehyde concentration by inhibiting alcohol absorption and regulating alcohol metabolism enzyme activity

Food Bioscience, Journal Year: 2024, Volume and Issue: unknown, P. 105742 - 105742

Published: Dec. 1, 2024

Language: Английский

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