Fibroblasts derived C3 promotes the progression of experimental periodontitis through macrophage M1 polarization and osteoclast differentiation
Abstract
Complement
C3
plays
a
critical
role
in
periodontitis.
However,
its
source,
and
underlying
mechanisms
remain
unclear.
In
our
study,
by
analyzing
single-cell
sequencing
data
from
mouse
model
of
periodontitis,
we
identified
that
is
primarily
derived
periodontal
fibroblasts.
Subsequently,
demonstrated
C3a
has
detrimental
effect
ligature-induced
C3ar-/-
mice
exhibited
significantly
less
destruction
support
tissues
compared
to
wild-type
mice,
characterized
mild
gingival
tissue
damage
reduced
alveolar
bone
loss.
This
reduction
was
associated
with
decreased
production
pro-inflammatory
mediators
osteoclast
infiltration
the
tissues.
Mechanistic
studies
suggested
could
promote
macrophage
polarization
differentiation.
Finally,
patients
found
results
observed
were
consistent
human
data.
Therefore,
findings
clearly
demonstrate
destructive
fibroblast-derived
driven
M1
These
strongly
feasibility
C3a-targeted
interventions
for
treatment
Research Square (Research Square), Journal Year: 2024, Volume and Issue: unknown
Published: Oct. 18, 2024
Language: Английский